Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients

Amarjit Parmar, Anne Maarit Lappalainen, Anu Liisa Paulina Paavola-Sakki, Leena Halme, Martti Antero Färkkilä, Ulla Turunen, Kimmo Kontula, A Aromaa, V Salomaa, Leena Palotie, J Halfvarson, L Törkvist, Mauro D´Amato, Päivi Marjaana Saavalainen, Elisabet Einarsdottir

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated
whether the known susceptibility loci for celiac disease (CelD) also associate with Crohn’s disease (CD) and/or ulcerative colitis (UC),
the two main forms of inflammatory bowel disease (IBD), in Finnish patients. A total of 45 genetic markers were genotyped in a
Finnish data set comprising 699 IBD patients and 2482 controls. Single-marker association with IBD and its subphenotypes was
tested. A meta-analysis with a Swedish UC data set was also performed. A total of 12 single-nucleotide polymorphisms associated
with CD and/or UC (Po0.05). In the subphenotype analysis, rs6974491-ELMO1 (P¼0.0002, odds ratio (OR): 2.20) and rs2298428-
UBE2L3 (P¼5.44105, OR: 2.59) associated with pediatric UC and CD, respectively. In the meta-analysis, rs4819388-ICOSLG
(P¼0.00042, OR: 0.79) associated with UC. In the subphenotype meta-analysis, rs1738074-TAGAP (P¼7.40105, OR: 0.61),
rs6974491-ELMO1 (P¼0.00052, OR: 1.73) and rs4819388-ICOSLG (P¼0.00019, OR: 0.75) associated with familial UC, pediatric UC
and sporadic UC, respectively. Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedish
populations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype.
Alkuperäiskielienglanti
LehtiGenes and Immunity
Vuosikerta13
Numero6
Sivut474-480
Sivumäärä7
ISSN1466-4879
DOI - pysyväislinkit
TilaJulkaistu - 2012
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3111 Biolääketieteet
  • 3121 Sisätaudit

Lainaa tätä

Parmar, Amarjit ; Lappalainen, Anne Maarit ; Paavola-Sakki, Anu Liisa Paulina ; Halme, Leena ; Färkkilä, Martti Antero ; Turunen, Ulla ; Kontula, Kimmo ; Aromaa, A ; Salomaa, V ; Palotie, Leena ; Halfvarson, J ; Törkvist, L ; D´Amato, Mauro ; Saavalainen, Päivi Marjaana ; Einarsdottir, Elisabet. / Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients. Julkaisussa: Genes and Immunity. 2012 ; Vuosikerta 13, Nro 6. Sivut 474-480.
@article{fef820dcd6a34031b274dd93b5cec6d3,
title = "Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients",
abstract = "Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigatedwhether the known susceptibility loci for celiac disease (CelD) also associate with Crohn’s disease (CD) and/or ulcerative colitis (UC),the two main forms of inflammatory bowel disease (IBD), in Finnish patients. A total of 45 genetic markers were genotyped in aFinnish data set comprising 699 IBD patients and 2482 controls. Single-marker association with IBD and its subphenotypes wastested. A meta-analysis with a Swedish UC data set was also performed. A total of 12 single-nucleotide polymorphisms associatedwith CD and/or UC (Po0.05). In the subphenotype analysis, rs6974491-ELMO1 (P¼0.0002, odds ratio (OR): 2.20) and rs2298428-UBE2L3 (P¼5.44105, OR: 2.59) associated with pediatric UC and CD, respectively. In the meta-analysis, rs4819388-ICOSLG(P¼0.00042, OR: 0.79) associated with UC. In the subphenotype meta-analysis, rs1738074-TAGAP (P¼7.40105, OR: 0.61),rs6974491-ELMO1 (P¼0.00052, OR: 1.73) and rs4819388-ICOSLG (P¼0.00019, OR: 0.75) associated with familial UC, pediatric UCand sporadic UC, respectively. Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedishpopulations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype.",
keywords = "3111 Biomedicine, 3121 Internal medicine",
author = "Amarjit Parmar and Lappalainen, {Anne Maarit} and Paavola-Sakki, {Anu Liisa Paulina} and Leena Halme and F{\"a}rkkil{\"a}, {Martti Antero} and Ulla Turunen and Kimmo Kontula and A Aromaa and V Salomaa and Leena Palotie and J Halfvarson and L T{\"o}rkvist and Mauro D´Amato and Saavalainen, {P{\"a}ivi Marjaana} and Elisabet Einarsdottir",
note = "WOS:000308455000006 Volume: Proceeding volume:",
year = "2012",
doi = "10.1038/gene.2012.21",
language = "English",
volume = "13",
pages = "474--480",
journal = "Genes and Immunity",
issn = "1466-4879",
publisher = "NATURE PUBLISHING GROUP",
number = "6",

}

Parmar, A, Lappalainen, AM, Paavola-Sakki, ALP, Halme, L, Färkkilä, MA, Turunen, U, Kontula, K, Aromaa, A, Salomaa, V, Palotie, L, Halfvarson, J, Törkvist, L, D´Amato, M, Saavalainen, PM & Einarsdottir, E 2012, 'Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients', Genes and Immunity, Vuosikerta 13, Nro 6, Sivut 474-480. https://doi.org/10.1038/gene.2012.21

Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients. / Parmar, Amarjit; Lappalainen, Anne Maarit; Paavola-Sakki, Anu Liisa Paulina; Halme, Leena; Färkkilä, Martti Antero; Turunen, Ulla; Kontula, Kimmo; Aromaa, A; Salomaa, V; Palotie, Leena; Halfvarson, J; Törkvist, L; D´Amato, Mauro; Saavalainen, Päivi Marjaana; Einarsdottir, Elisabet.

julkaisussa: Genes and Immunity, Vuosikerta 13, Nro 6, 2012, s. 474-480.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients

AU - Parmar, Amarjit

AU - Lappalainen, Anne Maarit

AU - Paavola-Sakki, Anu Liisa Paulina

AU - Halme, Leena

AU - Färkkilä, Martti Antero

AU - Turunen, Ulla

AU - Kontula, Kimmo

AU - Aromaa, A

AU - Salomaa, V

AU - Palotie, Leena

AU - Halfvarson, J

AU - Törkvist, L

AU - D´Amato, Mauro

AU - Saavalainen, Päivi Marjaana

AU - Einarsdottir, Elisabet

N1 - WOS:000308455000006 Volume: Proceeding volume:

PY - 2012

Y1 - 2012

N2 - Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigatedwhether the known susceptibility loci for celiac disease (CelD) also associate with Crohn’s disease (CD) and/or ulcerative colitis (UC),the two main forms of inflammatory bowel disease (IBD), in Finnish patients. A total of 45 genetic markers were genotyped in aFinnish data set comprising 699 IBD patients and 2482 controls. Single-marker association with IBD and its subphenotypes wastested. A meta-analysis with a Swedish UC data set was also performed. A total of 12 single-nucleotide polymorphisms associatedwith CD and/or UC (Po0.05). In the subphenotype analysis, rs6974491-ELMO1 (P¼0.0002, odds ratio (OR): 2.20) and rs2298428-UBE2L3 (P¼5.44105, OR: 2.59) associated with pediatric UC and CD, respectively. In the meta-analysis, rs4819388-ICOSLG(P¼0.00042, OR: 0.79) associated with UC. In the subphenotype meta-analysis, rs1738074-TAGAP (P¼7.40105, OR: 0.61),rs6974491-ELMO1 (P¼0.00052, OR: 1.73) and rs4819388-ICOSLG (P¼0.00019, OR: 0.75) associated with familial UC, pediatric UCand sporadic UC, respectively. Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedishpopulations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype.

AB - Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigatedwhether the known susceptibility loci for celiac disease (CelD) also associate with Crohn’s disease (CD) and/or ulcerative colitis (UC),the two main forms of inflammatory bowel disease (IBD), in Finnish patients. A total of 45 genetic markers were genotyped in aFinnish data set comprising 699 IBD patients and 2482 controls. Single-marker association with IBD and its subphenotypes wastested. A meta-analysis with a Swedish UC data set was also performed. A total of 12 single-nucleotide polymorphisms associatedwith CD and/or UC (Po0.05). In the subphenotype analysis, rs6974491-ELMO1 (P¼0.0002, odds ratio (OR): 2.20) and rs2298428-UBE2L3 (P¼5.44105, OR: 2.59) associated with pediatric UC and CD, respectively. In the meta-analysis, rs4819388-ICOSLG(P¼0.00042, OR: 0.79) associated with UC. In the subphenotype meta-analysis, rs1738074-TAGAP (P¼7.40105, OR: 0.61),rs6974491-ELMO1 (P¼0.00052, OR: 1.73) and rs4819388-ICOSLG (P¼0.00019, OR: 0.75) associated with familial UC, pediatric UCand sporadic UC, respectively. Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedishpopulations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype.

KW - 3111 Biomedicine

KW - 3121 Internal medicine

U2 - 10.1038/gene.2012.21

DO - 10.1038/gene.2012.21

M3 - Article

VL - 13

SP - 474

EP - 480

JO - Genes and Immunity

JF - Genes and Immunity

SN - 1466-4879

IS - 6

ER -