Association of plasma proteins with rate of cognitive decline and dementia: 20-year follow-up of the Whitehall II and ARIC cohort studies

Joni Lindbohm, Nina Mars, Keenan A. Walker, Archana Singh-Manoux, Gill Livingston, Eric J. Brunner, Pyry N. Sipilä, Kalle Saksela, Jane E. Ferrie, Ruth Lovering, Stephen A. Williams, Aroon D. Hingorani, Rebecca F. Gottesman, Henrik Zetterberg, Mika Kivimäki

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinen

Abstrakti

The role of circulating proteins in Alzheimer’s disease and related dementias is unknown. Using afollow-up of two decades, 4953 plasma proteins, and discovery (Whitehall II) and replication cohort(ARIC), we examined plasma proteins associated with cognitive decline rate and dementia. Afterreplication and adjustment for known dementia risk factors, fifteen proteins were associated withcognitive decline rate and dementia. None of these were amyloid, tau, or neurofilament-relatedproteins. Currently approved medications can target five of the proteins. The results supportsystemic pathogenesis of dementias, may aid in early diagnosis, and suggest potential targets fordrug development.
Alkuperäiskielienglanti
LehtimedRxiv
Sivumäärä69
DOI - pysyväislinkit
TilaJulkaistu - 20 marraskuuta 2020
OKM-julkaisutyyppiB1 Kirjoitus tieteellisessä aikakauslehdessä

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