TY - JOUR
T1 - Association of plasma proteins with rate of cognitive decline and dementia
T2 - 20-year follow-up of the Whitehall II and ARIC cohort studies
AU - Lindbohm, Joni
AU - Mars, Nina
AU - Walker, Keenan A.
AU - Singh-Manoux, Archana
AU - Livingston, Gill
AU - Brunner, Eric J.
AU - Sipilä, Pyry N.
AU - Saksela, Kalle
AU - Ferrie, Jane E.
AU - Lovering, Ruth
AU - Williams, Stephen A.
AU - Hingorani, Aroon D.
AU - Gottesman, Rebecca F.
AU - Zetterberg, Henrik
AU - Kivimäki, Mika
PY - 2020/11/20
Y1 - 2020/11/20
N2 - The role of circulating proteins in Alzheimer’s disease and related dementias is unknown. Using afollow-up of two decades, 4953 plasma proteins, and discovery (Whitehall II) and replication cohort(ARIC), we examined plasma proteins associated with cognitive decline rate and dementia. Afterreplication and adjustment for known dementia risk factors, fifteen proteins were associated withcognitive decline rate and dementia. None of these were amyloid, tau, or neurofilament-relatedproteins. Currently approved medications can target five of the proteins. The results supportsystemic pathogenesis of dementias, may aid in early diagnosis, and suggest potential targets fordrug development.
AB - The role of circulating proteins in Alzheimer’s disease and related dementias is unknown. Using afollow-up of two decades, 4953 plasma proteins, and discovery (Whitehall II) and replication cohort(ARIC), we examined plasma proteins associated with cognitive decline rate and dementia. Afterreplication and adjustment for known dementia risk factors, fifteen proteins were associated withcognitive decline rate and dementia. None of these were amyloid, tau, or neurofilament-relatedproteins. Currently approved medications can target five of the proteins. The results supportsystemic pathogenesis of dementias, may aid in early diagnosis, and suggest potential targets fordrug development.
KW - 3142 Public health care science, environmental and occupational health
KW - dementia
U2 - 10.1101/2020.11.18.20234070
DO - 10.1101/2020.11.18.20234070
M3 - Article
JO - medRxiv
JF - medRxiv
ER -