Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate-Induced Excitotoxicity

Dongfei Liu, Jian Chen, Tao Jiang, Wei Li, Yao Huang, Xiyi Lu, Zehua Liu, Weixia Zhang, Zheng Zhou, Qirui Ding, Helder Almeida Santos, Guoyong Yin, Jin Fan

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Our study demonstrates that the intrathecal administration of bare acetalated dextran (AcDX) microspheres can protect neurons from glutamate (GLU)-induced excitotoxicity, and therefore, repair the injured spinal cord. The neuroprotective feature of AcDX microspheres is achieved by sequestering GLU and calcium ions in cerebrospinal fluid (CSF), reducing the calcium ions influx into neurons and inhibiting the formation of ROS. Consequently, AcDX microspheres attenuate the expression of pro-apoptotic proteins (Calpain and Bax) and enhance the expression of anti-apoptotic protein (Bcl-2) both in vitro and in vivo. The intrathecal administration of AcDX microspheres immediately after traumatic injury leads to histological protection in spinal tissue and functional recovery in live animals. In summary, our work opens an exciting perspective toward the application of neuroprotective AcDX for the treatment of severe neurological diseases.
Alkuperäiskielienglanti
Artikkeli1706032
LehtiAdvanced Materials
Vuosikerta30
Numero14
Sivumäärä11
ISSN0935-9648
DOI - pysyväislinkit
TilaJulkaistu - 14 helmikuuta 2018
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 114 Fysiikka
  • 116 Kemia
  • 221 Nanoteknologia
  • 317 Farmasia

Lainaa tätä

Liu, Dongfei ; Chen, Jian ; Jiang, Tao ; Li, Wei ; Huang, Yao ; Lu, Xiyi ; Liu, Zehua ; Zhang, Weixia ; Zhou, Zheng ; Ding, Qirui ; Almeida Santos, Helder ; Yin, Guoyong ; Fan, Jin . / Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate-Induced Excitotoxicity. Julkaisussa: Advanced Materials. 2018 ; Vuosikerta 30, Nro 14.
@article{2f20ec021af047a9a200bbeb009f5ef3,
title = "Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate-Induced Excitotoxicity",
abstract = "Our study demonstrates that the intrathecal administration of bare acetalated dextran (AcDX) microspheres can protect neurons from glutamate (GLU)-induced excitotoxicity, and therefore, repair the injured spinal cord. The neuroprotective feature of AcDX microspheres is achieved by sequestering GLU and calcium ions in cerebrospinal fluid (CSF), reducing the calcium ions influx into neurons and inhibiting the formation of ROS. Consequently, AcDX microspheres attenuate the expression of pro-apoptotic proteins (Calpain and Bax) and enhance the expression of anti-apoptotic protein (Bcl-2) both in vitro and in vivo. The intrathecal administration of AcDX microspheres immediately after traumatic injury leads to histological protection in spinal tissue and functional recovery in live animals. In summary, our work opens an exciting perspective toward the application of neuroprotective AcDX for the treatment of severe neurological diseases.",
keywords = "114 Physical sciences, 116 Chemical sciences, 221 Nano-technology, 317 Pharmacy, acetalated dextran, alleviated excitotoxicity, calcium ion scavenging, glutamate adsorption, spinal cord injury, ACETALATED DEXTRAN MICROPARTICLES, CEREBROSPINAL-FLUID GLUTAMATE, DRUG-DELIVERY, NEURODEGENERATIVE DISEASES, MULTIDRUG DELIVERY, APOPTOSIS, REGENERATION, PATHOGENESIS, RELEASE, POLYMER",
author = "Dongfei Liu and Jian Chen and Tao Jiang and Wei Li and Yao Huang and Xiyi Lu and Zehua Liu and Weixia Zhang and Zheng Zhou and Qirui Ding and {Almeida Santos}, Helder and Guoyong Yin and Jin Fan",
year = "2018",
month = "2",
day = "14",
doi = "10.1002/adma.201706032",
language = "English",
volume = "30",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH",
number = "14",

}

Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate-Induced Excitotoxicity. / Liu, Dongfei; Chen, Jian ; Jiang, Tao; Li, Wei; Huang, Yao ; Lu, Xiyi ; Liu, Zehua; Zhang, Weixia; Zhou, Zheng ; Ding, Qirui ; Almeida Santos, Helder; Yin, Guoyong ; Fan, Jin .

julkaisussa: Advanced Materials, Vuosikerta 30, Nro 14, 1706032, 14.02.2018.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate-Induced Excitotoxicity

AU - Liu, Dongfei

AU - Chen, Jian

AU - Jiang, Tao

AU - Li, Wei

AU - Huang, Yao

AU - Lu, Xiyi

AU - Liu, Zehua

AU - Zhang, Weixia

AU - Zhou, Zheng

AU - Ding, Qirui

AU - Almeida Santos, Helder

AU - Yin, Guoyong

AU - Fan, Jin

PY - 2018/2/14

Y1 - 2018/2/14

N2 - Our study demonstrates that the intrathecal administration of bare acetalated dextran (AcDX) microspheres can protect neurons from glutamate (GLU)-induced excitotoxicity, and therefore, repair the injured spinal cord. The neuroprotective feature of AcDX microspheres is achieved by sequestering GLU and calcium ions in cerebrospinal fluid (CSF), reducing the calcium ions influx into neurons and inhibiting the formation of ROS. Consequently, AcDX microspheres attenuate the expression of pro-apoptotic proteins (Calpain and Bax) and enhance the expression of anti-apoptotic protein (Bcl-2) both in vitro and in vivo. The intrathecal administration of AcDX microspheres immediately after traumatic injury leads to histological protection in spinal tissue and functional recovery in live animals. In summary, our work opens an exciting perspective toward the application of neuroprotective AcDX for the treatment of severe neurological diseases.

AB - Our study demonstrates that the intrathecal administration of bare acetalated dextran (AcDX) microspheres can protect neurons from glutamate (GLU)-induced excitotoxicity, and therefore, repair the injured spinal cord. The neuroprotective feature of AcDX microspheres is achieved by sequestering GLU and calcium ions in cerebrospinal fluid (CSF), reducing the calcium ions influx into neurons and inhibiting the formation of ROS. Consequently, AcDX microspheres attenuate the expression of pro-apoptotic proteins (Calpain and Bax) and enhance the expression of anti-apoptotic protein (Bcl-2) both in vitro and in vivo. The intrathecal administration of AcDX microspheres immediately after traumatic injury leads to histological protection in spinal tissue and functional recovery in live animals. In summary, our work opens an exciting perspective toward the application of neuroprotective AcDX for the treatment of severe neurological diseases.

KW - 114 Physical sciences

KW - 116 Chemical sciences

KW - 221 Nano-technology

KW - 317 Pharmacy

KW - acetalated dextran

KW - alleviated excitotoxicity

KW - calcium ion scavenging

KW - glutamate adsorption

KW - spinal cord injury

KW - ACETALATED DEXTRAN MICROPARTICLES

KW - CEREBROSPINAL-FLUID GLUTAMATE

KW - DRUG-DELIVERY

KW - NEURODEGENERATIVE DISEASES

KW - MULTIDRUG DELIVERY

KW - APOPTOSIS

KW - REGENERATION

KW - PATHOGENESIS

KW - RELEASE

KW - POLYMER

U2 - 10.1002/adma.201706032

DO - 10.1002/adma.201706032

M3 - Article

VL - 30

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 14

M1 - 1706032

ER -