BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir

Wen-Fang Tang; Yu-Hsiu Chang; Cheng-Chin Lin; Jia-Rong Jheng; Chung-Fan Hsieh; Yuan-Fan Chin; Tein-Yao Chang; Jin-Ching Lee; Po-Huang Liang; Chia-Yi Lin; Guan-Hua Lin; Jie-Yun Cai; Yu-Li Chen; Yuan-Siao Chen; Shan-Ko Tsai; Ping-Cheng Liu; Chuen-Mi Yang; Tolou Shadbahr; Jing Tang; Yu-Lin Hsu; Chih-Heng Huang; Ling-Yu Wang; Jyh-Hwa Kau; Yi-Jen Hung; Hsin-Yi Lee; Wen-Chieh Wang; Hui-Ping Tsai; Jim-Tong Horng

doi:10.1128/aac.00956-23

BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir

Wen-Fang Tang, Yu-Hsiu Chang, Cheng-Chin Lin, Jia-Rong Jheng, Chung-Fan Hsieh, Yuan-Fan Chin, Tein-Yao Chang, Jin-Ching Lee, Po-Huang Liang, Chia-Yi Lin, Guan-Hua Lin, Jie-Yun Cai, Yu-Li Chen, Yuan-Siao Chen, Shan-Ko Tsai, Ping-Cheng Liu, Chuen-Mi Yang, Tolou Shadbahr, Jing Tang, Yu-Lin HsuChih-Heng Huang, Ling-Yu Wang, Jyh-Hwa Kau, Yi-Jen Hung, Hsin-Yi Lee, Wen-Chieh Wang, Hui-Ping Tsai, Jim-Tong Horng

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	e00956-23
Lehti	Antimicrobial Agents and Chemotherapy
Vuosikerta	68
Numero	4
Sivumäärä	26
ISSN	0066-4804
DOI - pysyväislinkit	https://doi.org/10.1128/aac.00956-23
Tila	Julkaistu - huhtik. 2024
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

3111 Biolääketieteet

Pääsy asiakirjaan

10.1128/aac.00956-23

https://journals.asm.org/doi/abs/10.1128/aac.00956-23

Siteeraa tätä

Tang, W.-F., Chang, Y.-H., Lin, C.-C., Jheng, J.-R., Hsieh, C.-F., Chin, Y.-F., Chang, T.-Y., Lee, J.-C., Liang, P.-H., Lin, C.-Y., Lin, G.-H., Cai, J.-Y., Chen, Y.-L., Chen, Y.-S., Tsai, S.-K., Liu, P.-C., Yang, C.-M., Shadbahr, T., Tang, J., ... Horng, J.-T. (2024). BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir. Antimicrobial Agents and Chemotherapy, 68(4), Artikkeli e00956-23. https://doi.org/10.1128/aac.00956-23

@article{7f8a962ddde745dabc67ac5cfe07da3d,

title = "BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir",

keywords = "Antiviral, Broad-spectrum antiviral, RdRp reporter assay, Remdesivir, SARS-CoV-2, Synergistic effect, 3111 Biomedicine",

author = "Wen-Fang Tang and Yu-Hsiu Chang and Cheng-Chin Lin and Jia-Rong Jheng and Chung-Fan Hsieh and Yuan-Fan Chin and Tein-Yao Chang and Jin-Ching Lee and Po-Huang Liang and Chia-Yi Lin and Guan-Hua Lin and Jie-Yun Cai and Yu-Li Chen and Yuan-Siao Chen and Shan-Ko Tsai and Ping-Cheng Liu and Chuen-Mi Yang and Tolou Shadbahr and Jing Tang and Yu-Lin Hsu and Chih-Heng Huang and Ling-Yu Wang and Jyh-Hwa Kau and Yi-Jen Hung and Hsin-Yi Lee and Wen-Chieh Wang and Hui-Ping Tsai and Jim-Tong Horng",

year = "2024",

month = apr,

doi = "10.1128/aac.00956-23",

language = "English",

volume = "68",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "4",

}

Tang, W-F, Chang, Y-H, Lin, C-C, Jheng, J-R, Hsieh, C-F, Chin, Y-F, Chang, T-Y, Lee, J-C, Liang, P-H, Lin, C-Y, Lin, G-H, Cai, J-Y, Chen, Y-L, Chen, Y-S, Tsai, S-K, Liu, P-C, Yang, C-M, Shadbahr, T , Tang, J, Hsu, Y-L, Huang, C-H, Wang, L-Y, Kau, J-H, Hung, Y-J, Lee, H-Y, Wang, W-C, Tsai, H-P & Horng, J-T 2024, 'BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir', Antimicrobial Agents and Chemotherapy, Vuosikerta 68, Nro 4, e00956-23. https://doi.org/10.1128/aac.00956-23

BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir. / Tang, Wen-Fang; Chang, Yu-Hsiu; Lin, Cheng-Chin et al.
julkaisussa: Antimicrobial Agents and Chemotherapy, Vuosikerta 68, Nro 4, e00956-23, 04.2024.

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

TY - JOUR

T1 - BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir

AU - Tang, Wen-Fang

AU - Chang, Yu-Hsiu

AU - Lin, Cheng-Chin

AU - Jheng, Jia-Rong

AU - Hsieh, Chung-Fan

AU - Chin, Yuan-Fan

AU - Chang, Tein-Yao

AU - Lee, Jin-Ching

AU - Liang, Po-Huang

AU - Lin, Chia-Yi

AU - Lin, Guan-Hua

AU - Cai, Jie-Yun

AU - Chen, Yu-Li

AU - Chen, Yuan-Siao

AU - Tsai, Shan-Ko

AU - Liu, Ping-Cheng

AU - Yang, Chuen-Mi

AU - Shadbahr, Tolou

AU - Tang, Jing

AU - Hsu, Yu-Lin

AU - Huang, Chih-Heng

AU - Wang, Ling-Yu

AU - Kau, Jyh-Hwa

AU - Hung, Yi-Jen

AU - Lee, Hsin-Yi

AU - Wang, Wen-Chieh

AU - Tsai, Hui-Ping

AU - Horng, Jim-Tong

PY - 2024/4

Y1 - 2024/4

KW - Antiviral

KW - Broad-spectrum antiviral

KW - RdRp reporter assay

KW - Remdesivir

KW - SARS-CoV-2

KW - Synergistic effect

KW - 3111 Biomedicine

U2 - 10.1128/aac.00956-23

DO - 10.1128/aac.00956-23

M3 - Article

SN - 0066-4804

VL - 68

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 4

M1 - e00956-23

ER -