Can social support alleviate inflammation associated with childhood adversities?

Silja Runsten, Katariina Korkeila, Markku Koskenvuo, Päivi Rautava, Olli Vainio, Jyrki Korkeila

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Objective: Childhood adversities have been linked to elevated high-sensitivity C-reactive protein (hsCRP), which has been associated with increased morbidity. Low social support has been reported to worsen the prognosis in heart disease and cancer, and high social support has been linked to lower hsCRP. We hypothesized that social support could be a mediating factor between childhood adversities and hsCRP. Methods: The sample was drawn from the data of the nationwide Health and Social Support Study (HeSSup Study) to which 25,898 Finns had responded in 1998. The cohort was stratified into groups of high and low social support, and the study group consisted of 100 women in both groups. Additionally, we invited a randomly drawn group of 50 subjects and a group of 62 women who had reported depressive symptoms. Of the 312 women, 116 participated in the study. Results: Social support score (Social Support Questionnaire, SSQ) was lower when the number of adverse experiences in childhood was high (r = - 0.251, P = 0.007). hsCRP and SSQ were inversely associated (r = - 0.188, P = 0.046). In the adjusted general linear model, the level of social support was significantly associated with hsCRP and there was a statistically significant interactive effect of small effect size of childhood adversities and the level of social support on hsCRP (ES = 0.123, P = 0.004). Conclusion: This finding suggests that childhood adversity may affect social relationships and that high social support may attenuate the health risks caused by childhood adverse experience.

Alkuperäiskielienglanti
LehtiNordic Journal of Psychiatry
Vuosikerta68
Numero2
Sivut137-144
Sivumäärä8
ISSN0803-9488
DOI - pysyväislinkit
TilaJulkaistu - helmikuuta 2014
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3142 Kansanterveystiede, ympäristö ja työterveys

Lainaa tätä

Runsten, Silja ; Korkeila, Katariina ; Koskenvuo, Markku ; Rautava, Päivi ; Vainio, Olli ; Korkeila, Jyrki. / Can social support alleviate inflammation associated with childhood adversities?. Julkaisussa: Nordic Journal of Psychiatry. 2014 ; Vuosikerta 68, Nro 2. Sivut 137-144.
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title = "Can social support alleviate inflammation associated with childhood adversities?",
abstract = "Objective: Childhood adversities have been linked to elevated high-sensitivity C-reactive protein (hsCRP), which has been associated with increased morbidity. Low social support has been reported to worsen the prognosis in heart disease and cancer, and high social support has been linked to lower hsCRP. We hypothesized that social support could be a mediating factor between childhood adversities and hsCRP. Methods: The sample was drawn from the data of the nationwide Health and Social Support Study (HeSSup Study) to which 25,898 Finns had responded in 1998. The cohort was stratified into groups of high and low social support, and the study group consisted of 100 women in both groups. Additionally, we invited a randomly drawn group of 50 subjects and a group of 62 women who had reported depressive symptoms. Of the 312 women, 116 participated in the study. Results: Social support score (Social Support Questionnaire, SSQ) was lower when the number of adverse experiences in childhood was high (r = - 0.251, P = 0.007). hsCRP and SSQ were inversely associated (r = - 0.188, P = 0.046). In the adjusted general linear model, the level of social support was significantly associated with hsCRP and there was a statistically significant interactive effect of small effect size of childhood adversities and the level of social support on hsCRP (ES = 0.123, P = 0.004). Conclusion: This finding suggests that childhood adversity may affect social relationships and that high social support may attenuate the health risks caused by childhood adverse experience.",
keywords = "3142 Public health care science, environmental and occupational health, childhood trauma, CRP, early stress, low-grade inflammation, social integration",
author = "Silja Runsten and Katariina Korkeila and Markku Koskenvuo and P{\"a}ivi Rautava and Olli Vainio and Jyrki Korkeila",
year = "2014",
month = "2",
doi = "10.3109/08039488.2013.786133",
language = "English",
volume = "68",
pages = "137--144",
journal = "Nordic Journal of Psychiatry",
issn = "0803-9488",
publisher = "TAYLOR & FRANCIS LTD",
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Can social support alleviate inflammation associated with childhood adversities? / Runsten, Silja; Korkeila, Katariina ; Koskenvuo, Markku; Rautava, Päivi; Vainio, Olli; Korkeila, Jyrki.

julkaisussa: Nordic Journal of Psychiatry, Vuosikerta 68, Nro 2, 02.2014, s. 137-144.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Can social support alleviate inflammation associated with childhood adversities?

AU - Runsten, Silja

AU - Korkeila, Katariina

AU - Koskenvuo, Markku

AU - Rautava, Päivi

AU - Vainio, Olli

AU - Korkeila, Jyrki

PY - 2014/2

Y1 - 2014/2

N2 - Objective: Childhood adversities have been linked to elevated high-sensitivity C-reactive protein (hsCRP), which has been associated with increased morbidity. Low social support has been reported to worsen the prognosis in heart disease and cancer, and high social support has been linked to lower hsCRP. We hypothesized that social support could be a mediating factor between childhood adversities and hsCRP. Methods: The sample was drawn from the data of the nationwide Health and Social Support Study (HeSSup Study) to which 25,898 Finns had responded in 1998. The cohort was stratified into groups of high and low social support, and the study group consisted of 100 women in both groups. Additionally, we invited a randomly drawn group of 50 subjects and a group of 62 women who had reported depressive symptoms. Of the 312 women, 116 participated in the study. Results: Social support score (Social Support Questionnaire, SSQ) was lower when the number of adverse experiences in childhood was high (r = - 0.251, P = 0.007). hsCRP and SSQ were inversely associated (r = - 0.188, P = 0.046). In the adjusted general linear model, the level of social support was significantly associated with hsCRP and there was a statistically significant interactive effect of small effect size of childhood adversities and the level of social support on hsCRP (ES = 0.123, P = 0.004). Conclusion: This finding suggests that childhood adversity may affect social relationships and that high social support may attenuate the health risks caused by childhood adverse experience.

AB - Objective: Childhood adversities have been linked to elevated high-sensitivity C-reactive protein (hsCRP), which has been associated with increased morbidity. Low social support has been reported to worsen the prognosis in heart disease and cancer, and high social support has been linked to lower hsCRP. We hypothesized that social support could be a mediating factor between childhood adversities and hsCRP. Methods: The sample was drawn from the data of the nationwide Health and Social Support Study (HeSSup Study) to which 25,898 Finns had responded in 1998. The cohort was stratified into groups of high and low social support, and the study group consisted of 100 women in both groups. Additionally, we invited a randomly drawn group of 50 subjects and a group of 62 women who had reported depressive symptoms. Of the 312 women, 116 participated in the study. Results: Social support score (Social Support Questionnaire, SSQ) was lower when the number of adverse experiences in childhood was high (r = - 0.251, P = 0.007). hsCRP and SSQ were inversely associated (r = - 0.188, P = 0.046). In the adjusted general linear model, the level of social support was significantly associated with hsCRP and there was a statistically significant interactive effect of small effect size of childhood adversities and the level of social support on hsCRP (ES = 0.123, P = 0.004). Conclusion: This finding suggests that childhood adversity may affect social relationships and that high social support may attenuate the health risks caused by childhood adverse experience.

KW - 3142 Public health care science, environmental and occupational health

KW - childhood trauma

KW - CRP

KW - early stress

KW - low-grade inflammation

KW - social integration

U2 - 10.3109/08039488.2013.786133

DO - 10.3109/08039488.2013.786133

M3 - Article

VL - 68

SP - 137

EP - 144

JO - Nordic Journal of Psychiatry

JF - Nordic Journal of Psychiatry

SN - 0803-9488

IS - 2

ER -