Challenges of Using In Vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier

Noora Sjöstedt, Hanna-Sisko Kortejärvi, Heidi Kidron, Kati-Sisko Vellonen, Arto Urtti, Marjo Yliperttula

Tutkimustuotos: ArtikkelijulkaisuKatsausartikkeliTieteellinenvertaisarvioitu

Alkuperäiskielienglanti
LehtiPharmaceutical Research
Vuosikerta31
Numero1
Sivut1-19
Sivumäärä19
ISSN0724-8741
DOI - pysyväislinkit
TilaJulkaistu - 2014
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

Tieteenalat

  • 317 Farmasia

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title = "Challenges of Using In Vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier",
keywords = "blood-brain barrier, efflux transport, in vitro-in vivo extrapolation, p-glycoprotein, physiologically based pharmacokinetic modeling, CENTRAL-NERVOUS-SYSTEM, PHYSIOLOGICALLY-BASED PHARMACOKINETICS, TARGETED ABSOLUTE PROTEOMICS, CARRIER-MEDIATED PROCESSES, CACO-2 CELL MONOLAYERS, PLASMA-PROTEIN BINDING, DRUG TRANSPORT, ATPASE ACTIVITY, ENDOTHELIAL-CELLS, TISSUE BINDING, 317 Pharmacy",
author = "Noora Sj{\"o}stedt and Hanna-Sisko Kortej{\"a}rvi and Heidi Kidron and Kati-Sisko Vellonen and Arto Urtti and Marjo Yliperttula",
year = "2014",
doi = "10.1007/s11095-013-1124-2",
language = "English",
volume = "31",
pages = "1--19",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "SPRINGER/PLENUM PUBLISHERS",
number = "1",

}

Challenges of Using In Vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier. / Sjöstedt, Noora; Kortejärvi, Hanna-Sisko; Kidron, Heidi; Vellonen, Kati-Sisko; Urtti, Arto; Yliperttula, Marjo.

julkaisussa: Pharmaceutical Research, Vuosikerta 31, Nro 1, 2014, s. 1-19.

Tutkimustuotos: ArtikkelijulkaisuKatsausartikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Challenges of Using In Vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier

AU - Sjöstedt, Noora

AU - Kortejärvi, Hanna-Sisko

AU - Kidron, Heidi

AU - Vellonen, Kati-Sisko

AU - Urtti, Arto

AU - Yliperttula, Marjo

PY - 2014

Y1 - 2014

KW - blood-brain barrier

KW - efflux transport

KW - in vitro-in vivo extrapolation

KW - p-glycoprotein

KW - physiologically based pharmacokinetic modeling

KW - CENTRAL-NERVOUS-SYSTEM

KW - PHYSIOLOGICALLY-BASED PHARMACOKINETICS

KW - TARGETED ABSOLUTE PROTEOMICS

KW - CARRIER-MEDIATED PROCESSES

KW - CACO-2 CELL MONOLAYERS

KW - PLASMA-PROTEIN BINDING

KW - DRUG TRANSPORT

KW - ATPASE ACTIVITY

KW - ENDOTHELIAL-CELLS

KW - TISSUE BINDING

KW - 317 Pharmacy

U2 - 10.1007/s11095-013-1124-2

DO - 10.1007/s11095-013-1124-2

M3 - Review Article

VL - 31

SP - 1

EP - 19

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 1

ER -