Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter)

Antti Rahikkala, Jessica M. Rosenholm, Helder Almeida Santos

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaKirjan luku tai artikkeliTieteellinenvertaisarvioitu

Kuvaus

Pharmaceutical nanocarriers are rapidly developing toward “magic bullets” with highly specified target cells and tissues, as well as controlled release of therapeutic agents. However, several challenges remain unanswered, such as the premature release of the drugs, the adverse side effects, and the toxic degradation products or nanoparticle accumulation in the organs. As one of the most interesting nanoplatforms, mesoporous silica nanoparticles (MSNs) feature as promising drug delivery platforms with a great capability to highly specialized functionalization and tunability. The diameter and shape of the particles, in tandem with the size and connectivity of the mesopores, can be controlled in a precise fashion during the fabrication process. The surface chemistry can also be tuned to allow for conjugation of functional molecules, such as prodrugs, targeting molecules, or responsive polymers for controlled drug release, as well as for controlling the surface charge according to the requirements of the application. High surface area allows loading diverse amounts of drugs, while the expandable pore size facilitates also the loading of larger therapeutic agents, such as proteins and DNA. Furthermore, silica biodegrades into silicic acid, which is nontoxic and is rapidly excreted via the urinary pathway. MSNs have been demonstrated to have potential applications as multifunctional delivery platforms with targeted delivery, controlled release, and theranostics, a few of which will be highlighted in this review.
Alkuperäiskielienglanti
OtsikkoBiomedical Applications of Functionalized Nanomaterials : Concepts, Development and Clinical Translation
ToimittajatBruno Sarmento, José das Neves
Sivumäärä32
JulkaisupaikkaSaint Louis
KustantajaElsevier Scientific Publ. Co
Julkaisupäivä15 maaliskuuta 2018
Sivut489–520
ISBN (painettu) 978-0-323-50878-0
DOI - pysyväislinkit
TilaJulkaistu - 15 maaliskuuta 2018
OKM-julkaisutyyppiA3 Kirjan tai muun kokoomateoksen osa

Julkaisusarja

NimiMicro and Nano Technologies

Tieteenalat

  • 317 Farmasia
  • 216 Materiaalitekniikka
  • 221 Nanoteknologia

Lainaa tätä

Rahikkala, A., Rosenholm, J. M., & Almeida Santos, H. (2018). Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter). teoksessa B. Sarmento, & J. das Neves (Toimittajat), Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation (Sivut 489–520). (Micro and Nano Technologies). Saint Louis: Elsevier Scientific Publ. Co. https://doi.org/10.1016/B978-0-323-50878-0.00016-1
Rahikkala, Antti ; Rosenholm, Jessica M. ; Almeida Santos, Helder. / Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter). Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation. Toimittaja / Bruno Sarmento ; José das Neves. Saint Louis : Elsevier Scientific Publ. Co, 2018. Sivut 489–520 (Micro and Nano Technologies).
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abstract = "Pharmaceutical nanocarriers are rapidly developing toward “magic bullets” with highly specified target cells and tissues, as well as controlled release of therapeutic agents. However, several challenges remain unanswered, such as the premature release of the drugs, the adverse side effects, and the toxic degradation products or nanoparticle accumulation in the organs. As one of the most interesting nanoplatforms, mesoporous silica nanoparticles (MSNs) feature as promising drug delivery platforms with a great capability to highly specialized functionalization and tunability. The diameter and shape of the particles, in tandem with the size and connectivity of the mesopores, can be controlled in a precise fashion during the fabrication process. The surface chemistry can also be tuned to allow for conjugation of functional molecules, such as prodrugs, targeting molecules, or responsive polymers for controlled drug release, as well as for controlling the surface charge according to the requirements of the application. High surface area allows loading diverse amounts of drugs, while the expandable pore size facilitates also the loading of larger therapeutic agents, such as proteins and DNA. Furthermore, silica biodegrades into silicic acid, which is nontoxic and is rapidly excreted via the urinary pathway. MSNs have been demonstrated to have potential applications as multifunctional delivery platforms with targeted delivery, controlled release, and theranostics, a few of which will be highlighted in this review.",
keywords = "317 Pharmacy, 216 Materials engineering, 221 Nano-technology",
author = "Antti Rahikkala and Rosenholm, {Jessica M.} and {Almeida Santos}, Helder",
year = "2018",
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doi = "10.1016/B978-0-323-50878-0.00016-1",
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Rahikkala, A, Rosenholm, JM & Almeida Santos, H 2018, Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter). julkaisussa B Sarmento & J das Neves (toim), Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation. Micro and Nano Technologies, Elsevier Scientific Publ. Co, Saint Louis, Sivut 489–520. https://doi.org/10.1016/B978-0-323-50878-0.00016-1

Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter). / Rahikkala, Antti ; Rosenholm, Jessica M.; Almeida Santos, Helder.

Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation. toim. / Bruno Sarmento; José das Neves. Saint Louis : Elsevier Scientific Publ. Co, 2018. s. 489–520 (Micro and Nano Technologies).

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaKirjan luku tai artikkeliTieteellinenvertaisarvioitu

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N2 - Pharmaceutical nanocarriers are rapidly developing toward “magic bullets” with highly specified target cells and tissues, as well as controlled release of therapeutic agents. However, several challenges remain unanswered, such as the premature release of the drugs, the adverse side effects, and the toxic degradation products or nanoparticle accumulation in the organs. As one of the most interesting nanoplatforms, mesoporous silica nanoparticles (MSNs) feature as promising drug delivery platforms with a great capability to highly specialized functionalization and tunability. The diameter and shape of the particles, in tandem with the size and connectivity of the mesopores, can be controlled in a precise fashion during the fabrication process. The surface chemistry can also be tuned to allow for conjugation of functional molecules, such as prodrugs, targeting molecules, or responsive polymers for controlled drug release, as well as for controlling the surface charge according to the requirements of the application. High surface area allows loading diverse amounts of drugs, while the expandable pore size facilitates also the loading of larger therapeutic agents, such as proteins and DNA. Furthermore, silica biodegrades into silicic acid, which is nontoxic and is rapidly excreted via the urinary pathway. MSNs have been demonstrated to have potential applications as multifunctional delivery platforms with targeted delivery, controlled release, and theranostics, a few of which will be highlighted in this review.

AB - Pharmaceutical nanocarriers are rapidly developing toward “magic bullets” with highly specified target cells and tissues, as well as controlled release of therapeutic agents. However, several challenges remain unanswered, such as the premature release of the drugs, the adverse side effects, and the toxic degradation products or nanoparticle accumulation in the organs. As one of the most interesting nanoplatforms, mesoporous silica nanoparticles (MSNs) feature as promising drug delivery platforms with a great capability to highly specialized functionalization and tunability. The diameter and shape of the particles, in tandem with the size and connectivity of the mesopores, can be controlled in a precise fashion during the fabrication process. The surface chemistry can also be tuned to allow for conjugation of functional molecules, such as prodrugs, targeting molecules, or responsive polymers for controlled drug release, as well as for controlling the surface charge according to the requirements of the application. High surface area allows loading diverse amounts of drugs, while the expandable pore size facilitates also the loading of larger therapeutic agents, such as proteins and DNA. Furthermore, silica biodegrades into silicic acid, which is nontoxic and is rapidly excreted via the urinary pathway. MSNs have been demonstrated to have potential applications as multifunctional delivery platforms with targeted delivery, controlled release, and theranostics, a few of which will be highlighted in this review.

KW - 317 Pharmacy

KW - 216 Materials engineering

KW - 221 Nano-technology

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SN - 978-0-323-50878-0

T3 - Micro and Nano Technologies

SP - 489

EP - 520

BT - Biomedical Applications of Functionalized Nanomaterials

A2 - Sarmento, Bruno

A2 - das Neves, José

PB - Elsevier Scientific Publ. Co

CY - Saint Louis

ER -

Rahikkala A, Rosenholm JM, Almeida Santos H. Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter). julkaisussa Sarmento B, das Neves J, toimittajat, Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation. Saint Louis: Elsevier Scientific Publ. Co. 2018. s. 489–520. (Micro and Nano Technologies). https://doi.org/10.1016/B978-0-323-50878-0.00016-1