Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models

Jaakko Itkonen; Ada Annala; Shirin Tavakoli; Blanca Arango-Gonzalez; Marius Ueffing; Elisa Toropainen; Marika Ruponen; Marco G. Casteleijn; Arto Urtti

doi:10.3390/pharmaceutics12070611

Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models

Jaakko Itkonen, Ada Annala, Shirin Tavakoli, Blanca Arango-Gonzalez, Marius Ueffing, Elisa Toropainen, Marika Ruponen, Marco G. Casteleijn, Arto Urtti

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	611
Lehti	Pharmaceutics
Vuosikerta	12
Numero	7
Sivumäärä	30
ISSN	1999-4923
DOI - pysyväislinkit	https://doi.org/10.3390/pharmaceutics12070611
Tila	Julkaistu - heinäkuuta 2020
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

317 Farmasia

Pääsy asiakirjaan

10.3390/pharmaceutics12070611

pharmaceutics-12-00611-v2Lopullinen julkaistu versio, 7 MBLisenssi: CC BY

Siteeraa tätä

Itkonen, J., Annala, A., Tavakoli, S., Arango-Gonzalez, B., Ueffing, M., Toropainen, E., Ruponen, M., Casteleijn, M. G., & Urtti, A. (2020). Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models. Pharmaceutics, 12(7), [611]. https://doi.org/10.3390/pharmaceutics12070611

Itkonen, Jaakko ; Annala, Ada ; Tavakoli, Shirin ; Arango-Gonzalez, Blanca ; Ueffing, Marius ; Toropainen, Elisa ; Ruponen, Marika ; Casteleijn, Marco G. ; Urtti, Arto. / Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models. Julkaisussa: Pharmaceutics. 2020 ; Vuosikerta 12, Nro 7.

@article{2d4f8b8578ac493faee5290aae677698,

title = "Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models",

keywords = "retinal penetration, neuroprotection, protein aggregation, stability, intravitreal delivery, CNTF, CILIARY NEUROTROPHIC FACTOR, INTRAOCULAR GENE-TRANSFER, GANGLION-CELL SURVIVAL, INTRAVITREAL INJECTION, MOUSE-MODEL, PHOTORECEPTOR SURVIVAL, INTERLEUKIN-6 RECEPTOR, PROTEIN STABILITY, DRUG STABILITY, OUTER SEGMENTS, 317 Pharmacy",

author = "Jaakko Itkonen and Ada Annala and Shirin Tavakoli and Blanca Arango-Gonzalez and Marius Ueffing and Elisa Toropainen and Marika Ruponen and Casteleijn, {Marco G.} and Arto Urtti",

year = "2020",

month = jul,

doi = "10.3390/pharmaceutics12070611",

language = "English",

volume = "12",

journal = "Pharmaceutics",

issn = "1999-4923",

publisher = "MDPI",

number = "7",

}

Itkonen, J, Annala, A, Tavakoli, S, Arango-Gonzalez, B, Ueffing, M, Toropainen, E, Ruponen, M, Casteleijn, MG & Urtti, A 2020, 'Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models', Pharmaceutics, Vuosikerta 12, Nro 7, 611. https://doi.org/10.3390/pharmaceutics12070611

Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models. / Itkonen, Jaakko; Annala, Ada; Tavakoli, Shirin; Arango-Gonzalez, Blanca; Ueffing, Marius; Toropainen, Elisa; Ruponen, Marika; Casteleijn, Marco G.; Urtti, Arto.

julkaisussa: Pharmaceutics, Vuosikerta 12, Nro 7, 611, 07.2020.

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › vertaisarvioitu

TY - JOUR

T1 - Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models

AU - Itkonen, Jaakko

AU - Annala, Ada

AU - Tavakoli, Shirin

AU - Arango-Gonzalez, Blanca

AU - Ueffing, Marius

AU - Toropainen, Elisa

AU - Ruponen, Marika

AU - Casteleijn, Marco G.

AU - Urtti, Arto

PY - 2020/7

Y1 - 2020/7

KW - retinal penetration

KW - neuroprotection

KW - protein aggregation

KW - stability

KW - intravitreal delivery

KW - CNTF

KW - CILIARY NEUROTROPHIC FACTOR

KW - INTRAOCULAR GENE-TRANSFER

KW - GANGLION-CELL SURVIVAL

KW - INTRAVITREAL INJECTION

KW - MOUSE-MODEL

KW - PHOTORECEPTOR SURVIVAL

KW - INTERLEUKIN-6 RECEPTOR

KW - PROTEIN STABILITY

KW - DRUG STABILITY

KW - OUTER SEGMENTS

KW - 317 Pharmacy

U2 - 10.3390/pharmaceutics12070611

DO - 10.3390/pharmaceutics12070611

M3 - Article

VL - 12

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 7

M1 - 611

ER -