Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17

Implications for Pharmacogenetics and Drug-Drug Interactions

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Alkuperäiskielienglanti
LehtiDrug Metabolism and Disposition
Vuosikerta46
Numero2
Sivut141-150
Sivumäärä10
ISSN0090-9556
DOI - pysyväislinkit
TilaJulkaistu - 1 helmikuuta 2018
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3111 Biolääketieteet
  • 317 Farmasia

Lainaa tätä

@article{1195a42b7d5a4ba0864a18e35be06008,
title = "Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions",
keywords = "OF-FUNCTION POLYMORPHISM, MECHANISM-BASED INHIBITION, HUMAN UDP-GLUCURONOSYLTRANSFERASES, CYTOCHROME-P450 2C19, HUMAN LIVER, PROTEIN EXPRESSION, MASS-SPECTROMETRY, PHARMACOKINETICS, CLOPIDOGREL, METABOLITE, 3111 Biomedicine, 317 Pharmacy",
author = "Helin{\"a} Kahma and Filppula, {Anne M.} and Mikko Neuvonen and Tarkiainen, {E. Katriina} and Aleksi Tornio and Holmberg, {Mikko T.} and Itkonen, {Matti K.} and Moshe Finel and Neuvonen, {Pertti J.} and Mikko Niemi and Backman, {Janne T.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1124/dmd.117.078162",
language = "English",
volume = "46",
pages = "141--150",
journal = "Drug Metabolism and Disposition",
issn = "1521-009X",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "2",

}

TY - JOUR

T1 - Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17

T2 - Implications for Pharmacogenetics and Drug-Drug Interactions

AU - Kahma, Helinä

AU - Filppula, Anne M.

AU - Neuvonen, Mikko

AU - Tarkiainen, E. Katriina

AU - Tornio, Aleksi

AU - Holmberg, Mikko T.

AU - Itkonen, Matti K.

AU - Finel, Moshe

AU - Neuvonen, Pertti J.

AU - Niemi, Mikko

AU - Backman, Janne T.

PY - 2018/2/1

Y1 - 2018/2/1

KW - OF-FUNCTION POLYMORPHISM

KW - MECHANISM-BASED INHIBITION

KW - HUMAN UDP-GLUCURONOSYLTRANSFERASES

KW - CYTOCHROME-P450 2C19

KW - HUMAN LIVER

KW - PROTEIN EXPRESSION

KW - MASS-SPECTROMETRY

KW - PHARMACOKINETICS

KW - CLOPIDOGREL

KW - METABOLITE

KW - 3111 Biomedicine

KW - 317 Pharmacy

U2 - 10.1124/dmd.117.078162

DO - 10.1124/dmd.117.078162

M3 - Article

VL - 46

SP - 141

EP - 150

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

SN - 1521-009X

IS - 2

ER -