Converting FENO by different flows to standard flow FENO

Paul Lassmann-Klee, Lauri Lehtimaki, Tuula Lindholm, Leo Pekka Malmberg, Anssi Sovijärvi, Päivi Piirilä

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

In clinical practice, assessment of expiratory nitric oxide (FENO ) may reveal eosinophilic airway inflammation in asthmatic and other pulmonary diseases. Currently, measuring of FENO is standardised to exhaled flow level of 50 mL/s, since the expiratory flow rate affects the FENO results. To enable the comparison of FENO measured with different expiratory flows, we firstly aimed to establish a conversion model to estimate FENO at the standard flow level, and secondly, validate it in five external populations. FENO measurements were obtained from 30 volunteers (mixed adult population) at the following multiple expiratory flow rates: 50, 30, 100 and 300 mL/s, after different mouthwash settings, and a conversion model was developed. We tested the conversion model in five populations: healthy adults, healthy children, and patients with COPD, asthma, and alveolitis. FENO conversions in the mixed adult population, in healthy adults and in children, showed the lowest deviation between estimated FENO from 100 mL/s and measured FENO at 50 mL/s: -0•28 ppb, -0•44 ppb, and 0•27 ppb respectively. In patients with COPD, asthma and alveolitis the deviation was -1•16 ppb, -1•68 ppb, and 1•47 ppb respectively. We proposed a valid model to convert FENO in healthy or mixed populations, as well as in subjects with obstructive pulmonary diseases, and found it suitable for converting FENO measured with different expiratory flows to the standard flow in large epidemiological data, but not on individual level. In conclusion, a model to convert FENO from different flows to the standard flow was established and validated.
Alkuperäiskielienglanti
LehtiClinical Physiology and Functional Imaging
ISSN1475-0961
DOI - pysyväislinkit
TilaE-pub ahead of print - 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lainaa tätä

@article{348d5697cff14c8fac445de54cc60bb1,
title = "Converting FENO by different flows to standard flow FENO",
abstract = "In clinical practice, assessment of expiratory nitric oxide (FENO ) may reveal eosinophilic airway inflammation in asthmatic and other pulmonary diseases. Currently, measuring of FENO is standardised to exhaled flow level of 50 mL/s, since the expiratory flow rate affects the FENO results. To enable the comparison of FENO measured with different expiratory flows, we firstly aimed to establish a conversion model to estimate FENO at the standard flow level, and secondly, validate it in five external populations. FENO measurements were obtained from 30 volunteers (mixed adult population) at the following multiple expiratory flow rates: 50, 30, 100 and 300 mL/s, after different mouthwash settings, and a conversion model was developed. We tested the conversion model in five populations: healthy adults, healthy children, and patients with COPD, asthma, and alveolitis. FENO conversions in the mixed adult population, in healthy adults and in children, showed the lowest deviation between estimated FENO from 100 mL/s and measured FENO at 50 mL/s: -0•28 ppb, -0•44 ppb, and 0•27 ppb respectively. In patients with COPD, asthma and alveolitis the deviation was -1•16 ppb, -1•68 ppb, and 1•47 ppb respectively. We proposed a valid model to convert FENO in healthy or mixed populations, as well as in subjects with obstructive pulmonary diseases, and found it suitable for converting FENO measured with different expiratory flows to the standard flow in large epidemiological data, but not on individual level. In conclusion, a model to convert FENO from different flows to the standard flow was established and validated.",
author = "Paul Lassmann-Klee and Lauri Lehtimaki and Tuula Lindholm and Malmberg, {Leo Pekka} and Anssi Sovij{\"a}rvi and P{\"a}ivi Piiril{\"a}",
year = "2019",
doi = "doi: 10.1111/cpf.12574",
language = "English",
journal = "Clinical Physiology and Functional Imaging",
issn = "1475-0961",
publisher = "Wiley",

}

Converting FENO by different flows to standard flow FENO. / Lassmann-Klee, Paul; Lehtimaki, Lauri; Lindholm, Tuula; Malmberg, Leo Pekka; Sovijärvi, Anssi; Piirilä, Päivi.

julkaisussa: Clinical Physiology and Functional Imaging, 2019.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Converting FENO by different flows to standard flow FENO

AU - Lassmann-Klee, Paul

AU - Lehtimaki, Lauri

AU - Lindholm, Tuula

AU - Malmberg, Leo Pekka

AU - Sovijärvi, Anssi

AU - Piirilä, Päivi

PY - 2019

Y1 - 2019

N2 - In clinical practice, assessment of expiratory nitric oxide (FENO ) may reveal eosinophilic airway inflammation in asthmatic and other pulmonary diseases. Currently, measuring of FENO is standardised to exhaled flow level of 50 mL/s, since the expiratory flow rate affects the FENO results. To enable the comparison of FENO measured with different expiratory flows, we firstly aimed to establish a conversion model to estimate FENO at the standard flow level, and secondly, validate it in five external populations. FENO measurements were obtained from 30 volunteers (mixed adult population) at the following multiple expiratory flow rates: 50, 30, 100 and 300 mL/s, after different mouthwash settings, and a conversion model was developed. We tested the conversion model in five populations: healthy adults, healthy children, and patients with COPD, asthma, and alveolitis. FENO conversions in the mixed adult population, in healthy adults and in children, showed the lowest deviation between estimated FENO from 100 mL/s and measured FENO at 50 mL/s: -0•28 ppb, -0•44 ppb, and 0•27 ppb respectively. In patients with COPD, asthma and alveolitis the deviation was -1•16 ppb, -1•68 ppb, and 1•47 ppb respectively. We proposed a valid model to convert FENO in healthy or mixed populations, as well as in subjects with obstructive pulmonary diseases, and found it suitable for converting FENO measured with different expiratory flows to the standard flow in large epidemiological data, but not on individual level. In conclusion, a model to convert FENO from different flows to the standard flow was established and validated.

AB - In clinical practice, assessment of expiratory nitric oxide (FENO ) may reveal eosinophilic airway inflammation in asthmatic and other pulmonary diseases. Currently, measuring of FENO is standardised to exhaled flow level of 50 mL/s, since the expiratory flow rate affects the FENO results. To enable the comparison of FENO measured with different expiratory flows, we firstly aimed to establish a conversion model to estimate FENO at the standard flow level, and secondly, validate it in five external populations. FENO measurements were obtained from 30 volunteers (mixed adult population) at the following multiple expiratory flow rates: 50, 30, 100 and 300 mL/s, after different mouthwash settings, and a conversion model was developed. We tested the conversion model in five populations: healthy adults, healthy children, and patients with COPD, asthma, and alveolitis. FENO conversions in the mixed adult population, in healthy adults and in children, showed the lowest deviation between estimated FENO from 100 mL/s and measured FENO at 50 mL/s: -0•28 ppb, -0•44 ppb, and 0•27 ppb respectively. In patients with COPD, asthma and alveolitis the deviation was -1•16 ppb, -1•68 ppb, and 1•47 ppb respectively. We proposed a valid model to convert FENO in healthy or mixed populations, as well as in subjects with obstructive pulmonary diseases, and found it suitable for converting FENO measured with different expiratory flows to the standard flow in large epidemiological data, but not on individual level. In conclusion, a model to convert FENO from different flows to the standard flow was established and validated.

U2 - doi: 10.1111/cpf.12574

DO - doi: 10.1111/cpf.12574

M3 - Article

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

SN - 1475-0961

ER -