Coralline hydroxyapatite reinforced with polylactide fibres in lumbar interbody implantation

Pekka Ylinen, Marja Raekallio, Ritva Taurio, Kimmo Vihtonen, Seppo Vainionpää, Esa Partio, Pertti Törmälä, Pentti Rokkanen

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Abstrakti

    "Porous hydroxyapatite HA blocks reinforced with poly-l/dl-lactide fibres were used to maintain the lumbar disc space and to start to create intercorporeal fusion in 23 growing pigs. In four pigs two emptied non adjacent disc spaces were left open. After 3, 6, 12 and 16 weeks the implanted disc blocks were studied radiologically, histologically, histomorphometrically, microradiographically, and with oxytetracycline fluorescence. In plain films slight to moderate ossification of the implanted disc spaces was detected at 12 and 16 weeks. Resorption of the implants was seen radiologically from 3 weeks and fragmentation from 12 weeks onwards. In microradiographs disintegration of the coralline inner structure started at 3 weeks. Histologically, connective tissue ingrowth was seen inside the porous structure from three weeks onwards. Small amounts of new bone were visible and connective tissue inside the implant increased from a mean of 65.6% at 3 weeks to a mean of 79.4% at 16 weeks histomorphometrically. The bone ingrowth varied from 0.7 to 1.7%. A loss of height in the implanted disc spaces was seen ( p < 0.05, linear regression analysis). In control pigs the emptied disc spaces lost their height similarly. The implants used were not strong enough to maintain the lumbar disc height. (C) 2005 Springer Science + Business Media, Inc."
    Alkuperäiskielienglanti
    LehtiJournal of Materials Science: Materials in Medicine
    Vuosikerta16
    Numero4
    Sivut325-331
    Sivumäärä7
    ISSN0957-4530
    DOI - pysyväislinkit
    TilaJulkaistu - 2005
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Tieteenalat

    • 413 Eläinlääketiede
    • eläinlääketiede
    • sika
    • kirurgia
    • tuki- ja liikuntaelimet
    • polvet
    • biomateriaalit
    • siirrännäiset
    • hydroksiapatiitti

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