Correlating the Gut Microbiome to Health and Disease

Tatiana Milena Marques, John Peter Ganda-Mall, Richard Forsgård, Rebecca Wall, Robert J. Brummer, Willem M. De Vos

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaKirjan luku tai artikkeliTieteellinenvertaisarvioitu

Abstrakti

The gut microbiota is a complex ecosystem consisting of a diverse population of prokaryotes that has a symbiotic relationship with its host; thus, it plays a vital role in the host's health. Our understanding of the effect of the gut microbiome on health and disease has grown substantially over the past decades, mostly because of recent advances in sequencing and other high-throughput technologies. Given its high metabolic potential, proximity to the intestinal mucosa, and interaction with the immune system, it is not surprising that the gut microbiome is an important partaker of human health. Evidence of the importance of the gut microbiome in human health and disease is the growing number of conditions now linked to changes in the resident gut microbiota, including recurrent Clostridium difficile infections, inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, allergies, neurological diseases, and metabolic diseases. Research into this field of the association of the gut microbiome with health and disease continues to expand at a rapid pace as we come to accept the gut microbiome as our “second genome.” Targeting the gut microbiome to restore/modulate its composition with the use of antibiotics, probiotics, prebiotics, and even fecal microbiota transplantation is considered a promising future strategy for the development of new solutions in the treatment of various diseases associated with an imbalance in microbiota composition and functioning.

Alkuperäiskielienglanti
OtsikkoThe Gut-Brain Axis
Sivumäärä36
KustantajaElsevier
Julkaisupäivä1 tammik. 2024
Painos2. ed.
Sivut1-36
ISBN (painettu)9780323983020
ISBN (elektroninen)9780323999717
DOI - pysyväislinkit
TilaJulkaistu - 1 tammik. 2024
OKM-julkaisutyyppiA3 Kirjan tai muun kokoomateoksen osa

Lisätietoja

Publisher Copyright:
© 2024 Elsevier Inc. All rights reserved.

Tieteenalat

  • 3111 Biolääketieteet

Siteeraa tätä