Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development

Ari Pekka Mähönen, Anthony Bishopp, Masayuki Higuchi, Kaisa M Nieminen, Kaori Kinoshita, Kirsi Törmäkangas, Yoshihisa Ikeda, Atsuhiro Oka, Tatsuo Kakimoto, Yrjö Helariutta

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    The cell lineages that form the transporting tissues (xylem and phloem) and the intervening pluripotent procambial tissue originate from stem cells near the root tip. We demonstrate that in Arabidopsis, cytokinin phytohormones negatively regulate protoxylem specification. AHP6, an inhibitory pseudophosphotransfer protein, counteracts cytokinin signaling, allowing protoxylem formation. Conversely, cytokinin signaling negatively regulates the spatial domain of AHP6 expression. Thus, by controlling the identity of cell lineages, the reciprocal interaction of cytokinin signaling and its spatially specific modulator regulates proliferation and differentiation of cell lineages during vascular development, demonstrating a previously unrecognized regulatory circuit underlying meristem organization.
    Alkuperäiskielienglanti
    LehtiScience
    Vuosikerta311
    Numero5757
    Sivut94-98
    Sivumäärä5
    ISSN0036-8075
    DOI - pysyväislinkit
    TilaJulkaistu - 2006
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Tieteenalat

    • 118 Biotieteet

    Lainaa tätä

    Mähönen, Ari Pekka ; Bishopp, Anthony ; Higuchi, Masayuki ; Nieminen, Kaisa M ; Kinoshita, Kaori ; Törmäkangas, Kirsi ; Ikeda, Yoshihisa ; Oka, Atsuhiro ; Kakimoto, Tatsuo ; Helariutta, Yrjö. / Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development. Julkaisussa: Science. 2006 ; Vuosikerta 311, Nro 5757. Sivut 94-98.
    @article{c1b571ddf8d341ec87b966a8ffc0706e,
    title = "Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development",
    abstract = "The cell lineages that form the transporting tissues (xylem and phloem) and the intervening pluripotent procambial tissue originate from stem cells near the root tip. We demonstrate that in Arabidopsis, cytokinin phytohormones negatively regulate protoxylem specification. AHP6, an inhibitory pseudophosphotransfer protein, counteracts cytokinin signaling, allowing protoxylem formation. Conversely, cytokinin signaling negatively regulates the spatial domain of AHP6 expression. Thus, by controlling the identity of cell lineages, the reciprocal interaction of cytokinin signaling and its spatially specific modulator regulates proliferation and differentiation of cell lineages during vascular development, demonstrating a previously unrecognized regulatory circuit underlying meristem organization.",
    keywords = "118 Biological sciences",
    author = "M{\"a}h{\"o}nen, {Ari Pekka} and Anthony Bishopp and Masayuki Higuchi and Nieminen, {Kaisa M} and Kaori Kinoshita and Kirsi T{\"o}rm{\"a}kangas and Yoshihisa Ikeda and Atsuhiro Oka and Tatsuo Kakimoto and Yrj{\"o} Helariutta",
    year = "2006",
    doi = "10.1126/science.1118875",
    language = "English",
    volume = "311",
    pages = "94--98",
    journal = "Science",
    issn = "0036-8075",
    publisher = "American Association for the Advancement of Science (AAAS)",
    number = "5757",

    }

    Mähönen, AP, Bishopp, A, Higuchi, M, Nieminen, KM, Kinoshita, K, Törmäkangas, K, Ikeda, Y, Oka, A, Kakimoto, T & Helariutta, Y 2006, 'Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development' Science, Vuosikerta 311, Nro 5757, Sivut 94-98. https://doi.org/10.1126/science.1118875

    Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development. / Mähönen, Ari Pekka; Bishopp, Anthony; Higuchi, Masayuki; Nieminen, Kaisa M; Kinoshita, Kaori; Törmäkangas, Kirsi; Ikeda, Yoshihisa; Oka, Atsuhiro; Kakimoto, Tatsuo; Helariutta, Yrjö.

    julkaisussa: Science, Vuosikerta 311, Nro 5757, 2006, s. 94-98.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development

    AU - Mähönen, Ari Pekka

    AU - Bishopp, Anthony

    AU - Higuchi, Masayuki

    AU - Nieminen, Kaisa M

    AU - Kinoshita, Kaori

    AU - Törmäkangas, Kirsi

    AU - Ikeda, Yoshihisa

    AU - Oka, Atsuhiro

    AU - Kakimoto, Tatsuo

    AU - Helariutta, Yrjö

    PY - 2006

    Y1 - 2006

    N2 - The cell lineages that form the transporting tissues (xylem and phloem) and the intervening pluripotent procambial tissue originate from stem cells near the root tip. We demonstrate that in Arabidopsis, cytokinin phytohormones negatively regulate protoxylem specification. AHP6, an inhibitory pseudophosphotransfer protein, counteracts cytokinin signaling, allowing protoxylem formation. Conversely, cytokinin signaling negatively regulates the spatial domain of AHP6 expression. Thus, by controlling the identity of cell lineages, the reciprocal interaction of cytokinin signaling and its spatially specific modulator regulates proliferation and differentiation of cell lineages during vascular development, demonstrating a previously unrecognized regulatory circuit underlying meristem organization.

    AB - The cell lineages that form the transporting tissues (xylem and phloem) and the intervening pluripotent procambial tissue originate from stem cells near the root tip. We demonstrate that in Arabidopsis, cytokinin phytohormones negatively regulate protoxylem specification. AHP6, an inhibitory pseudophosphotransfer protein, counteracts cytokinin signaling, allowing protoxylem formation. Conversely, cytokinin signaling negatively regulates the spatial domain of AHP6 expression. Thus, by controlling the identity of cell lineages, the reciprocal interaction of cytokinin signaling and its spatially specific modulator regulates proliferation and differentiation of cell lineages during vascular development, demonstrating a previously unrecognized regulatory circuit underlying meristem organization.

    KW - 118 Biological sciences

    U2 - 10.1126/science.1118875

    DO - 10.1126/science.1118875

    M3 - Article

    VL - 311

    SP - 94

    EP - 98

    JO - Science

    JF - Science

    SN - 0036-8075

    IS - 5757

    ER -