Dereplication of natural products with antimicrobial and anticancer activity from Brazilian cyanobacteria.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments.
Alkuperäiskielienglanti
Artikkeli2020, 12, 12
LehtiToxins
Vuosikerta12
Numero12
Sivumäärä17
ISSN2072-6651
TilaJulkaistu - tammikuuta 2020
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lainaa tätä

@article{f635bab05ebe4754abb5c3bc9c50c844,
title = "Dereplication of natural products with antimicrobial and anticancer activity from Brazilian cyanobacteria.",
abstract = "Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments.",
author = "Shishido, {Tania Keiko} and {Vicentini Popin}, Rafael and Jouni Jokela and Matti Wahlsten and Fiore, {Marli F{\'a}tima} and David Fewer and Lars Herfindal and Kaarina Sivonen",
year = "2020",
month = "1",
language = "English",
volume = "12",
journal = "Toxins",
issn = "2072-6651",
publisher = "MDPI",
number = "12",

}

Dereplication of natural products with antimicrobial and anticancer activity from Brazilian cyanobacteria. / Shishido, Tania Keiko; Vicentini Popin, Rafael; Jokela, Jouni; Wahlsten, Matti; Fiore, Marli Fátima; Fewer, David; Herfindal, Lars; Sivonen, Kaarina.

julkaisussa: Toxins, Vuosikerta 12, Nro 12, 2020, 12, 12, 01.2020.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Dereplication of natural products with antimicrobial and anticancer activity from Brazilian cyanobacteria.

AU - Shishido, Tania Keiko

AU - Vicentini Popin, Rafael

AU - Jokela, Jouni

AU - Wahlsten, Matti

AU - Fiore, Marli Fátima

AU - Fewer, David

AU - Herfindal, Lars

AU - Sivonen, Kaarina

PY - 2020/1

Y1 - 2020/1

N2 - Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments.

AB - Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments.

M3 - Article

VL - 12

JO - Toxins

JF - Toxins

SN - 2072-6651

IS - 12

M1 - 2020, 12, 12

ER -