Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors

Ziga Jakopin; Janez Ilas; Michaela Barancokova; Matjaz Brvar; Paivi Tammela; Marija Sollner Dolenc; Tihomir Tomasic; Danijel Kikelj

doi:10.1016/j.ejmech.2017.02.046

Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors

Ziga Jakopin, Janez Ilas, Michaela Barancokova, Matjaz Brvar, Paivi Tammela, Marija Sollner Dolenc, Tihomir Tomasic, Danijel Kikelj

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Lehti	European Journal of Medicinal Chemistry
Vuosikerta	130
Sivut	171-184
Sivumäärä	14
ISSN	0223-5234
DOI - pysyväislinkit	https://doi.org/10.1016/j.ejmech.2017.02.046
Tila	Julkaistu - 21 huhtik. 2017
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

317 Farmasia

Pääsy asiakirjaan

10.1016/j.ejmech.2017.02.046

Jakopin et al_2017_accepted

Phenotypic biosensor-based HTS and mode of action analysis by metabolomics and transcriptomics for enhancing antimicrobial drug discovery against Gram-negative bacteria
Tammela, P. (Principal Investigator)
01/09/2014 → 31/08/2019
Projekti: Tutkimusprojekti
EC-FP7-KBBE-2009-3-2-01-245137: Exploring Marine Resources for Bioactive Compounds: From Discovery to Sustainable Production and Industrial Applications (MAREX)
Kiuru, P. (Muu), Lipiäinen, T. (Muu), Tammela, P. (Muu), Montalvão, S. (Osallistuja), Lillsunde, K.-E. (Osallistuja), Vuorela, H. (Muu) & Yli-Kauhaluoma, J. (Muu)
01/08/2010 → 31/07/2014
Projekti: Tutkimusprojekti

Siteeraa tätä

@article{cd5932fba6dd400aa6016dd5575f3c7c,

title = "Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors",

keywords = "1,2,4-Oxadiazoles, DNA gyrase inhibition, Topoisomerase IV inhibition, Antibacterial screening, Computer-aided drug design, ATP-BINDING SITE, TOPOISOMERASE-IV, ANTIBACTERIAL ACTIVITY, PYRROLOPYRIMIDINE INHIBITORS, STAPHYLOCOCCUS-AUREUS, N-PHENYLINDOLAMIDES, IIA TOPOISOMERASES, BUILDING-BLOCKS, BROAD-SPECTRUM, B GYRB, 317 Pharmacy",

author = "Ziga Jakopin and Janez Ilas and Michaela Barancokova and Matjaz Brvar and Paivi Tammela and Dolenc, {Marija Sollner} and Tihomir Tomasic and Danijel Kikelj",

year = "2017",

month = apr,

day = "21",

doi = "10.1016/j.ejmech.2017.02.046",

language = "English",

volume = "130",

pages = "171--184",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

}

TY - JOUR

T1 - Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors

AU - Jakopin, Ziga

AU - Ilas, Janez

AU - Barancokova, Michaela

AU - Brvar, Matjaz

AU - Tammela, Paivi

AU - Dolenc, Marija Sollner

AU - Tomasic, Tihomir

AU - Kikelj, Danijel

PY - 2017/4/21

Y1 - 2017/4/21

KW - 1,2,4-Oxadiazoles

KW - DNA gyrase inhibition

KW - Topoisomerase IV inhibition

KW - Antibacterial screening

KW - Computer-aided drug design

KW - ATP-BINDING SITE

KW - TOPOISOMERASE-IV

KW - ANTIBACTERIAL ACTIVITY

KW - PYRROLOPYRIMIDINE INHIBITORS

KW - STAPHYLOCOCCUS-AUREUS

KW - N-PHENYLINDOLAMIDES

KW - IIA TOPOISOMERASES

KW - BUILDING-BLOCKS

KW - BROAD-SPECTRUM

KW - B GYRB

KW - 317 Pharmacy

U2 - 10.1016/j.ejmech.2017.02.046

DO - 10.1016/j.ejmech.2017.02.046

M3 - Article

SN - 0223-5234

VL - 130

SP - 171

EP - 184

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors

Tieteenalat

Pääsy asiakirjaan

Projektit

Phenotypic biosensor-based HTS and mode of action analysis by metabolomics and transcriptomics for enhancing antimicrobial drug discovery against Gram-negative bacteria

EC-FP7-KBBE-2009-3-2-01-245137: Exploring Marine Resources for Bioactive Compounds: From Discovery to Sustainable Production and Industrial Applications (MAREX)

Siteeraa tätä