Does farm environment protect against type 1 diabetes mellitus?

Sanna Heikkinen, Janne Mikael Pitkäniemi, Maritta L. Kilpeläinen, Markku Koskenvuo

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Aims/Hypothesis:Hygiene hypothesis has been shown valid in respect of allergies and asthma but has not been, however, sufficiently studied in relation to type 1 diabetes mellitus. This study investigates the effect of childhood farm environment on the prevalence of type 1 diabetes mellitus in Finnish children and young adults.Methods:Data come from a questionnaire study carried out in 2007 (N = 5805). Prevalence of type 1 diabetes mellitus was analysed according to the type of the rural exposure below the age of 18 years. Associations were estimated and tested using Bayesian methods.Results:Consistent suggestive evidence of the inverse association of childhood's farm environment with the occurrence of type 1 diabetes mellitus was shown, even though conclusive results were not reached.Conclusion/Interpretation:Exposure to a broad variety of non-pathogenic environmental microorganisms during childhood might have a protective effect on type 1 diabetes mellitus. Results clearly suggest that further research is well grounded with larger samples.

Alkuperäiskielienglanti
LehtiDiabetes and Vascular Disease Research
Vuosikerta10
Numero4
Sivut375-377
Sivumäärä3
ISSN1479-1641
DOI - pysyväislinkit
TilaJulkaistu - 2013
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3142 Kansanterveystiede, ympäristö ja työterveys

Lainaa tätä

Heikkinen, Sanna ; Pitkäniemi, Janne Mikael ; Kilpeläinen, Maritta L. ; Koskenvuo, Markku. / Does farm environment protect against type 1 diabetes mellitus?. Julkaisussa: Diabetes and Vascular Disease Research. 2013 ; Vuosikerta 10, Nro 4. Sivut 375-377.
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title = "Does farm environment protect against type 1 diabetes mellitus?",
abstract = "Aims/Hypothesis:Hygiene hypothesis has been shown valid in respect of allergies and asthma but has not been, however, sufficiently studied in relation to type 1 diabetes mellitus. This study investigates the effect of childhood farm environment on the prevalence of type 1 diabetes mellitus in Finnish children and young adults.Methods:Data come from a questionnaire study carried out in 2007 (N = 5805). Prevalence of type 1 diabetes mellitus was analysed according to the type of the rural exposure below the age of 18 years. Associations were estimated and tested using Bayesian methods.Results:Consistent suggestive evidence of the inverse association of childhood's farm environment with the occurrence of type 1 diabetes mellitus was shown, even though conclusive results were not reached.Conclusion/Interpretation:Exposure to a broad variety of non-pathogenic environmental microorganisms during childhood might have a protective effect on type 1 diabetes mellitus. Results clearly suggest that further research is well grounded with larger samples.",
keywords = "3142 Public health care science, environmental and occupational health, type 1 diabetes, hygiene hypothesis, microbial deprivation, farm, living environment, epidemiology",
author = "Sanna Heikkinen and Pitk{\"a}niemi, {Janne Mikael} and Kilpel{\"a}inen, {Maritta L.} and Markku Koskenvuo",
year = "2013",
doi = "10.1177/1479164112474907",
language = "English",
volume = "10",
pages = "375--377",
journal = "Diabetes and Vascular Disease Research",
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Does farm environment protect against type 1 diabetes mellitus? / Heikkinen, Sanna; Pitkäniemi, Janne Mikael; Kilpeläinen, Maritta L.; Koskenvuo, Markku.

julkaisussa: Diabetes and Vascular Disease Research, Vuosikerta 10, Nro 4, 2013, s. 375-377.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Does farm environment protect against type 1 diabetes mellitus?

AU - Heikkinen, Sanna

AU - Pitkäniemi, Janne Mikael

AU - Kilpeläinen, Maritta L.

AU - Koskenvuo, Markku

PY - 2013

Y1 - 2013

N2 - Aims/Hypothesis:Hygiene hypothesis has been shown valid in respect of allergies and asthma but has not been, however, sufficiently studied in relation to type 1 diabetes mellitus. This study investigates the effect of childhood farm environment on the prevalence of type 1 diabetes mellitus in Finnish children and young adults.Methods:Data come from a questionnaire study carried out in 2007 (N = 5805). Prevalence of type 1 diabetes mellitus was analysed according to the type of the rural exposure below the age of 18 years. Associations were estimated and tested using Bayesian methods.Results:Consistent suggestive evidence of the inverse association of childhood's farm environment with the occurrence of type 1 diabetes mellitus was shown, even though conclusive results were not reached.Conclusion/Interpretation:Exposure to a broad variety of non-pathogenic environmental microorganisms during childhood might have a protective effect on type 1 diabetes mellitus. Results clearly suggest that further research is well grounded with larger samples.

AB - Aims/Hypothesis:Hygiene hypothesis has been shown valid in respect of allergies and asthma but has not been, however, sufficiently studied in relation to type 1 diabetes mellitus. This study investigates the effect of childhood farm environment on the prevalence of type 1 diabetes mellitus in Finnish children and young adults.Methods:Data come from a questionnaire study carried out in 2007 (N = 5805). Prevalence of type 1 diabetes mellitus was analysed according to the type of the rural exposure below the age of 18 years. Associations were estimated and tested using Bayesian methods.Results:Consistent suggestive evidence of the inverse association of childhood's farm environment with the occurrence of type 1 diabetes mellitus was shown, even though conclusive results were not reached.Conclusion/Interpretation:Exposure to a broad variety of non-pathogenic environmental microorganisms during childhood might have a protective effect on type 1 diabetes mellitus. Results clearly suggest that further research is well grounded with larger samples.

KW - 3142 Public health care science, environmental and occupational health

KW - type 1 diabetes

KW - hygiene hypothesis

KW - microbial deprivation

KW - farm

KW - living environment

KW - epidemiology

U2 - 10.1177/1479164112474907

DO - 10.1177/1479164112474907

M3 - Article

VL - 10

SP - 375

EP - 377

JO - Diabetes and Vascular Disease Research

JF - Diabetes and Vascular Disease Research

SN - 1479-1641

IS - 4

ER -