Dpp/BMP transport mechanism is required for wing venation in the sawfly Athalia rosae.

Shinya Matsuda, Naotoshi Yoshiyama, Jaana Künnapuu-Vulli, Masatsugu Hatakeyama, Osamu Shimmi

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Abstrakti

The pattern of wing venation varies considerably among different groups of
insects and has been used as a means of species-specific identification. However,
little is known about how wing venation is established and diversified among
insects. The decapentaplegic (Dpp)/bone morphogenetic protein (BMP) signaling
pathway plays a critical role in wing vein formation during the pupal stages in
Drosophila melanogaster. A key mechanism is BMP transport from the longitudinal
veins (LVs) to the posterior crossvein (PCV) by the BMP-binding proteins, short
gastrulation (Sog) and twisted gastrulation2/crossveinless (Tsg2/Cv). To
investigate whether the BMP transport mechanism is utilized to specify insect
wing vein patterns in other than Drosophila, we used the sawfly Athalia rosae as
a model, which has distinct venation patterns in the fore- and hindwings. Here,
we show that Ar-dpp is ubiquitously expressed in both the fore- and hindwings,
but is required for localized BMP signaling that reflects distinct wing vein
patterns between the fore- and hindwings. By isolating Ar-tsg/cv in the sawfly,
we found that Ar-Tsg/Cv is also required for BMP signaling in wing vein formation
and retains the ability to transport Dpp. These data suggest that the BMP
transport system is widely used to redistribute Dpp to specify wing venation and
may be a basal mechanism underlying diversified wing vein patterns among insects.
Alkuperäiskielienglanti
LehtiInsect Biochemistry and Molecular Biology
Vuosikerta43
Numero5
Sivut466-473
Sivumäärä8
ISSN0965-1748
DOI - pysyväislinkit
TilaJulkaistu - toukokuuta 2013
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 1184 Genetiikka, kehitysbiologia, fysiologia

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