Ellagitannins, ellagic acid derivatives, stilbenes and flavonoids in antibacterial stem bark and leaf extracts of African medicinal plants Combretum psidioides and Combretum fragrans

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaKonferenssiartikkeliTieteellinenvertaisarvioitu

Kuvaus

Combretum psidioides and C. fragrans are used as decoctions for diarrhea and wounds in African traditional medicine [1]. In Nigeria, C. fragrans is used for the treatment of Blackleg disease in cattle among Fulani pastoralists. There exists no research on antibacterial compounds of these species but some phytochemical investigations have been performed on C. psidioides; fourteen phenanthrenes and stilbenes are known from the heart wood and pentacyclic triterpenoids have been characterized from the roots [2].
We have found that methanol and butanol extracts of the stem bark of C. psidioides gave good growth inhibitory effects against Mycobacterium smegmatis, S. aureus and P. aeruginosa. Our UHPLC-MS-QTOF results show that the stem bark of C. psidioides contains corilagin and punicalagin along with other ellagitannins as well as ellagic acid rhamnoside. These compounds have not previously been identified in C. psidioides. In addition, combretastatin B-2 along with its dihydrostilbene derivative were for the first time identified in the stem bark of C. psidioides.
A leaf extract of C. fragrans showed promising antibacterial effects, especially against Micrococcus luteus and S. aureus. Our preliminary HPLC-DAD results indicate that this extract contains luteolin and related flavonoids and three unknown ellagitannins. Mass spectrometric data is needed to confirm the identity of the compounds.
Alkuperäiskielienglanti
OtsikkoUnknown host publication
Sivumäärä1
JulkaisupaikkaBudapest
KustantajaPlanta Medica
Julkaisupäivä2015
Sivut1-1
DOI - pysyväislinkit
TilaJulkaistu - 2015
OKM-julkaisutyyppiA4 Artikkeli konferenssijulkaisuussa
Tapahtuma63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) - Budapest, Unkari
Kesto: 23 elokuuta 201527 elokuuta 2015
Konferenssinumero: 63

Lisätietoja


Volume:
Proceeding volume:

Lainaa tätä

@inproceedings{2271bbe20f7841c79c0a622417c9df38,
title = "Ellagitannins, ellagic acid derivatives, stilbenes and flavonoids in antibacterial stem bark and leaf extracts of African medicinal plants Combretum psidioides and Combretum fragrans",
abstract = "Combretum psidioides and C. fragrans are used as decoctions for diarrhea and wounds in African traditional medicine [1]. In Nigeria, C. fragrans is used for the treatment of Blackleg disease in cattle among Fulani pastoralists. There exists no research on antibacterial compounds of these species but some phytochemical investigations have been performed on C. psidioides; fourteen phenanthrenes and stilbenes are known from the heart wood and pentacyclic triterpenoids have been characterized from the roots [2].We have found that methanol and butanol extracts of the stem bark of C. psidioides gave good growth inhibitory effects against Mycobacterium smegmatis, S. aureus and P. aeruginosa. Our UHPLC-MS-QTOF results show that the stem bark of C. psidioides contains corilagin and punicalagin along with other ellagitannins as well as ellagic acid rhamnoside. These compounds have not previously been identified in C. psidioides. In addition, combretastatin B-2 along with its dihydrostilbene derivative were for the first time identified in the stem bark of C. psidioides.A leaf extract of C. fragrans showed promising antibacterial effects, especially against Micrococcus luteus and S. aureus. Our preliminary HPLC-DAD results indicate that this extract contains luteolin and related flavonoids and three unknown ellagitannins. Mass spectrometric data is needed to confirm the identity of the compounds.",
author = "Salih, {Enass Yousif Abdelkarium} and Pia Fyhrquist and Laakso, {Into Johannes} and Vuorela, {Heikki Juhani} and Riitta Julkunen-Tiitto",
note = "Volume: Proceeding volume:",
year = "2015",
doi = "10.1055/s-0035-1565627",
language = "English",
pages = "1--1",
booktitle = "Unknown host publication",
publisher = "Planta Medica",
address = "Portugal",

}

Salih, EYA, Fyhrquist, P, Laakso, IJ, Vuorela, HJ & Julkunen-Tiitto, R 2015, Ellagitannins, ellagic acid derivatives, stilbenes and flavonoids in antibacterial stem bark and leaf extracts of African medicinal plants Combretum psidioides and Combretum fragrans. julkaisussa Unknown host publication. Planta Medica, Budapest, Sivut 1-1, 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Budapest, Unkari, 23/08/2015. https://doi.org/10.1055/s-0035-1565627

Ellagitannins, ellagic acid derivatives, stilbenes and flavonoids in antibacterial stem bark and leaf extracts of African medicinal plants Combretum psidioides and Combretum fragrans. / Salih, Enass Yousif Abdelkarium; Fyhrquist, Pia; Laakso, Into Johannes; Vuorela, Heikki Juhani; Julkunen-Tiitto, Riitta.

Unknown host publication. Budapest : Planta Medica, 2015. s. 1-1.

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussaKonferenssiartikkeliTieteellinenvertaisarvioitu

TY - GEN

T1 - Ellagitannins, ellagic acid derivatives, stilbenes and flavonoids in antibacterial stem bark and leaf extracts of African medicinal plants Combretum psidioides and Combretum fragrans

AU - Salih, Enass Yousif Abdelkarium

AU - Fyhrquist, Pia

AU - Laakso, Into Johannes

AU - Vuorela, Heikki Juhani

AU - Julkunen-Tiitto, Riitta

N1 - Volume: Proceeding volume:

PY - 2015

Y1 - 2015

N2 - Combretum psidioides and C. fragrans are used as decoctions for diarrhea and wounds in African traditional medicine [1]. In Nigeria, C. fragrans is used for the treatment of Blackleg disease in cattle among Fulani pastoralists. There exists no research on antibacterial compounds of these species but some phytochemical investigations have been performed on C. psidioides; fourteen phenanthrenes and stilbenes are known from the heart wood and pentacyclic triterpenoids have been characterized from the roots [2].We have found that methanol and butanol extracts of the stem bark of C. psidioides gave good growth inhibitory effects against Mycobacterium smegmatis, S. aureus and P. aeruginosa. Our UHPLC-MS-QTOF results show that the stem bark of C. psidioides contains corilagin and punicalagin along with other ellagitannins as well as ellagic acid rhamnoside. These compounds have not previously been identified in C. psidioides. In addition, combretastatin B-2 along with its dihydrostilbene derivative were for the first time identified in the stem bark of C. psidioides.A leaf extract of C. fragrans showed promising antibacterial effects, especially against Micrococcus luteus and S. aureus. Our preliminary HPLC-DAD results indicate that this extract contains luteolin and related flavonoids and three unknown ellagitannins. Mass spectrometric data is needed to confirm the identity of the compounds.

AB - Combretum psidioides and C. fragrans are used as decoctions for diarrhea and wounds in African traditional medicine [1]. In Nigeria, C. fragrans is used for the treatment of Blackleg disease in cattle among Fulani pastoralists. There exists no research on antibacterial compounds of these species but some phytochemical investigations have been performed on C. psidioides; fourteen phenanthrenes and stilbenes are known from the heart wood and pentacyclic triterpenoids have been characterized from the roots [2].We have found that methanol and butanol extracts of the stem bark of C. psidioides gave good growth inhibitory effects against Mycobacterium smegmatis, S. aureus and P. aeruginosa. Our UHPLC-MS-QTOF results show that the stem bark of C. psidioides contains corilagin and punicalagin along with other ellagitannins as well as ellagic acid rhamnoside. These compounds have not previously been identified in C. psidioides. In addition, combretastatin B-2 along with its dihydrostilbene derivative were for the first time identified in the stem bark of C. psidioides.A leaf extract of C. fragrans showed promising antibacterial effects, especially against Micrococcus luteus and S. aureus. Our preliminary HPLC-DAD results indicate that this extract contains luteolin and related flavonoids and three unknown ellagitannins. Mass spectrometric data is needed to confirm the identity of the compounds.

U2 - 10.1055/s-0035-1565627

DO - 10.1055/s-0035-1565627

M3 - Conference contribution

SP - 1

EP - 1

BT - Unknown host publication

PB - Planta Medica

CY - Budapest

ER -