Endosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking and homoeostasis. Sterols can enter, and apparently also exit, endosomal compartments via both vesicular and non-vesicular mechanisms. A number of studies have focused on endosomal sterol removal as its defects lead to cholesterol storage diseases. So far, the bulk of evidence on endosomal sterol egress describes the involvement of membrane trafficking machineries. interestingly, two late endosomal sterol-binding proteins were recently shown to regulate the movement of late endosomes along cytoskeletal tracks. These studies provide the first indications of how non-vesicular and vesicular mechanisms may co-operate in endosomal sterol trafficking.
Alkuperäiskielienglanti
LehtiBiochemical Society Transactions
Vuosikerta34
Numeropart 3
Sivut392-394
Sivumäärä3
ISSN0300-5127
TilaJulkaistu - 2006
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lainaa tätä

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title = "Endosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet",
abstract = "The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking and homoeostasis. Sterols can enter, and apparently also exit, endosomal compartments via both vesicular and non-vesicular mechanisms. A number of studies have focused on endosomal sterol removal as its defects lead to cholesterol storage diseases. So far, the bulk of evidence on endosomal sterol egress describes the involvement of membrane trafficking machineries. interestingly, two late endosomal sterol-binding proteins were recently shown to regulate the movement of late endosomes along cytoskeletal tracks. These studies provide the first indications of how non-vesicular and vesicular mechanisms may co-operate in endosomal sterol trafficking.",
author = "Maarit H{\"o}ltt{\"a}-Vuori and Elina Ikonen",
year = "2006",
language = "English",
volume = "34",
pages = "392--394",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd.",
number = "part 3",

}

Endosomal cholesterol traffic : vesicular and non-vesicular mechanisms meet. / Hölttä-Vuori, Maarit; Ikonen, Elina.

julkaisussa: Biochemical Society Transactions, Vuosikerta 34, Nro part 3, 2006, s. 392-394.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Endosomal cholesterol traffic

T2 - vesicular and non-vesicular mechanisms meet

AU - Hölttä-Vuori, Maarit

AU - Ikonen, Elina

PY - 2006

Y1 - 2006

N2 - The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking and homoeostasis. Sterols can enter, and apparently also exit, endosomal compartments via both vesicular and non-vesicular mechanisms. A number of studies have focused on endosomal sterol removal as its defects lead to cholesterol storage diseases. So far, the bulk of evidence on endosomal sterol egress describes the involvement of membrane trafficking machineries. interestingly, two late endosomal sterol-binding proteins were recently shown to regulate the movement of late endosomes along cytoskeletal tracks. These studies provide the first indications of how non-vesicular and vesicular mechanisms may co-operate in endosomal sterol trafficking.

AB - The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking and homoeostasis. Sterols can enter, and apparently also exit, endosomal compartments via both vesicular and non-vesicular mechanisms. A number of studies have focused on endosomal sterol removal as its defects lead to cholesterol storage diseases. So far, the bulk of evidence on endosomal sterol egress describes the involvement of membrane trafficking machineries. interestingly, two late endosomal sterol-binding proteins were recently shown to regulate the movement of late endosomes along cytoskeletal tracks. These studies provide the first indications of how non-vesicular and vesicular mechanisms may co-operate in endosomal sterol trafficking.

M3 - Article

VL - 34

SP - 392

EP - 394

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - part 3

ER -