Epicardial transplantation of atrial appendage micrograft patch salvages myocardium after infarction

Yanbo Xie, Milla Lampinen, Juuso Takala, Vilbert Sikorski, Rabah Soliymani, Miikka Tarkia, Maciej Lalowski, Eero Mervaala, Markku Kupari, Zhe Zheng, Shengshou Hu, Ari Harjula, Esko Kankuri

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Abstrakti

BACKGROUND
Ischemic heart disease remains the leading cause of mortality and morbidity worldwide despite improved possibilities in medical care. Alongside interventional therapies, such as coronary artery bypass grafting, adjuvant tissue-engineered and cell-based treatments can provide regenerative improvement. Unfortunately, most of these advanced approaches require multiple lengthy and costly preparation stages without delivering significant clinical benefits.
METHODS
We evaluated the effect of epicardially delivered minute pieces of atrial appendage tissue material, defined as atrial appendage micrografts (AAMs), in mouse myocardial infarction model. An extracellular matrix patch was used to cover and fix the AAMs onto the surface of the infarcted heart.
RESULTS
The matrix-covered AAMs salvaged the heart from infarction-induced loss of functional myocardium and attenuated scarring. Site-selective proteomics of injured ischemic and uninjured distal myocardium from AAMs-treated and untreated tissue sections revealed an increased expression of several cardiac regeneration-associated proteins (i.e. periostin, transglutaminases and glutathione peroxidases) as well as activation of pathways responsible for angio- and cardiogenesis in relation to AAMs therapy.
CONCLUSIONS
Epicardial delivery of AAMs encased in an extracellular matrix patch scaffold salvages functional cardiac tissue from ischemic injury and restricts fibrosis after myocardial infarction. Our results support the use of AAMs as tissue-based therapy adjuvants for salvaging the ischemic myocardium.
Alkuperäiskielienglanti
LehtiJournal of Heart and Lung Transplantation
Sivumäärä12
ISSN1053-2498
DOI - pysyväislinkit
TilaHyväksytty/In press - 7 huhtikuuta 2020
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3126 Kirurgia, anestesiologia, tehohoito, radiologia

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