Kuvaus

Background: A novel biomarker of aging at birth, namely epigenetic
gestational age (GA) based on DNA methylation in fetal cord
blood, has been recently developed to accurately estimate GA at
birth. We examined whether this aging biomarker prospectively
predicted psychiatric problems during early childhood.
Methods: 407 mothers from the PREDO Study filled in the Child
Behavior Checklist at child’s mean age of 3.7 (SD = 0.75) years. DNA
was extracted from cord blood and methylation was analyzed with
Illumina 450k array. DNA methylation (DNAm) GA of fetal cord
blood DNA was calculated from 148 CpG sites shown to have high
accuracy in predicting chronological GA. Epigenetic GA was calculated
as arithmetic difference betweenDNAmGAand chronological
GA.
Results: In boys only child lower epigenetic GA (lower DNAm
GA compared to chronological GA) was prospectively associated
with higher total behavioral (p = 0.047), emotionally reactive
(p = 0.035), and withdrawn (p = 0.004) problems in models adjusting
for chronological GA, cord blood cell-type composition, genetic
population stratification, and child age at the time of testing.
Conclusions: Epigenetic GA immaturity seems to be developmentally
disadvantageous for boys, who in early childhood show
higher psychiatric problems in maternal reports.
Alkuperäiskielienglanti
LehtiPsychoneuroendocrinology
Vuosikerta83S
Sivut52-52
Sivumäärä1
ISSN0306-4530
DOI - pysyväislinkit
TilaJulkaistu - syyskuuta 2017
OKM-julkaisutyyppiEi sovellu
Tapahtuma47th Annual Meeting of the International Society of Psychoneuroendocrinology - Zurich, Sveitsi
Kesto: 7 syyskuuta 20179 syyskuuta 2017

Lisätietoja


Volume: 83
Proceeding volume:

Lainaa tätä

@article{050ea91654414acfa0e8bcf352f92cbe,
title = "Epigenetic clock at birth and psychiatric problems during early childhood",
abstract = "Background: A novel biomarker of aging at birth, namely epigeneticgestational age (GA) based on DNA methylation in fetal cordblood, has been recently developed to accurately estimate GA atbirth. We examined whether this aging biomarker prospectivelypredicted psychiatric problems during early childhood.Methods: 407 mothers from the PREDO Study filled in the ChildBehavior Checklist at child’s mean age of 3.7 (SD = 0.75) years. DNAwas extracted from cord blood and methylation was analyzed withIllumina 450k array. DNA methylation (DNAm) GA of fetal cordblood DNA was calculated from 148 CpG sites shown to have highaccuracy in predicting chronological GA. Epigenetic GA was calculatedas arithmetic difference betweenDNAmGAand chronologicalGA.Results: In boys only child lower epigenetic GA (lower DNAmGA compared to chronological GA) was prospectively associatedwith higher total behavioral (p = 0.047), emotionally reactive(p = 0.035), and withdrawn (p = 0.004) problems in models adjustingfor chronological GA, cord blood cell-type composition, geneticpopulation stratification, and child age at the time of testing.Conclusions: Epigenetic GA immaturity seems to be developmentallydisadvantageous for boys, who in early childhood showhigher psychiatric problems in maternal reports.",
author = "Anna Suarez and Jari Lahti and Darina Czamara and Marius Lahti and Knight, {Anna K.} and Polina Girchenko and Esa H{\"a}m{\"a}l{\"a}inen and Eero Kajantie and Hannele Laivuori and Villa, {Pia M.} and Reynolds, {Rebecca M.} and Smith, {Alicia K.} and Binder, {Elisabeth B.} and Katri R{\"a}ikk{\"o}nen",
note = "Volume: 83 Proceeding volume:",
year = "2017",
month = "9",
doi = "10.1016/j.psyneuen.2017.07.381",
language = "English",
volume = "83S",
pages = "52--52",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "Elsevier Scientific Publ. Co",

}

Epigenetic clock at birth and psychiatric problems during early childhood. / Suarez, Anna; Lahti, Jari; Czamara, Darina; Lahti, Marius; Knight, Anna K.; Girchenko, Polina; Hämäläinen, Esa; Kajantie, Eero; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Smith, Alicia K.; Binder, Elisabeth B.; Räikkönen, Katri.

julkaisussa: Psychoneuroendocrinology, Vuosikerta 83S, 09.2017, s. 52-52.

Tutkimustuotos: ArtikkelijulkaisuKonferenssiesitelmän abstraktiTutkimus

TY - JOUR

T1 - Epigenetic clock at birth and psychiatric problems during early childhood

AU - Suarez, Anna

AU - Lahti, Jari

AU - Czamara, Darina

AU - Lahti, Marius

AU - Knight, Anna K.

AU - Girchenko, Polina

AU - Hämäläinen, Esa

AU - Kajantie, Eero

AU - Laivuori, Hannele

AU - Villa, Pia M.

AU - Reynolds, Rebecca M.

AU - Smith, Alicia K.

AU - Binder, Elisabeth B.

AU - Räikkönen, Katri

N1 - Volume: 83 Proceeding volume:

PY - 2017/9

Y1 - 2017/9

N2 - Background: A novel biomarker of aging at birth, namely epigeneticgestational age (GA) based on DNA methylation in fetal cordblood, has been recently developed to accurately estimate GA atbirth. We examined whether this aging biomarker prospectivelypredicted psychiatric problems during early childhood.Methods: 407 mothers from the PREDO Study filled in the ChildBehavior Checklist at child’s mean age of 3.7 (SD = 0.75) years. DNAwas extracted from cord blood and methylation was analyzed withIllumina 450k array. DNA methylation (DNAm) GA of fetal cordblood DNA was calculated from 148 CpG sites shown to have highaccuracy in predicting chronological GA. Epigenetic GA was calculatedas arithmetic difference betweenDNAmGAand chronologicalGA.Results: In boys only child lower epigenetic GA (lower DNAmGA compared to chronological GA) was prospectively associatedwith higher total behavioral (p = 0.047), emotionally reactive(p = 0.035), and withdrawn (p = 0.004) problems in models adjustingfor chronological GA, cord blood cell-type composition, geneticpopulation stratification, and child age at the time of testing.Conclusions: Epigenetic GA immaturity seems to be developmentallydisadvantageous for boys, who in early childhood showhigher psychiatric problems in maternal reports.

AB - Background: A novel biomarker of aging at birth, namely epigeneticgestational age (GA) based on DNA methylation in fetal cordblood, has been recently developed to accurately estimate GA atbirth. We examined whether this aging biomarker prospectivelypredicted psychiatric problems during early childhood.Methods: 407 mothers from the PREDO Study filled in the ChildBehavior Checklist at child’s mean age of 3.7 (SD = 0.75) years. DNAwas extracted from cord blood and methylation was analyzed withIllumina 450k array. DNA methylation (DNAm) GA of fetal cordblood DNA was calculated from 148 CpG sites shown to have highaccuracy in predicting chronological GA. Epigenetic GA was calculatedas arithmetic difference betweenDNAmGAand chronologicalGA.Results: In boys only child lower epigenetic GA (lower DNAmGA compared to chronological GA) was prospectively associatedwith higher total behavioral (p = 0.047), emotionally reactive(p = 0.035), and withdrawn (p = 0.004) problems in models adjustingfor chronological GA, cord blood cell-type composition, geneticpopulation stratification, and child age at the time of testing.Conclusions: Epigenetic GA immaturity seems to be developmentallydisadvantageous for boys, who in early childhood showhigher psychiatric problems in maternal reports.

U2 - 10.1016/j.psyneuen.2017.07.381

DO - 10.1016/j.psyneuen.2017.07.381

M3 - Meeting Abstract

VL - 83S

SP - 52

EP - 52

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -