Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Objective: Matrix metalloproteinases (MMPs) degrade extracellular matrix and are involved in tumor invasion and metastasis in various cancers. In pancreatic cancer, MMP-2 expression is upregulated and correlates with tumor recurrence. The aim of this study was to evaluate the prognostic significance of MMP-2 in pancreatic ductal adenocarcinoma. Methods: MMP-2 expression was assessed by immunohistochemistry in 127 patients operated on at Helsinki University Hospital from 1974 to 1998, with expression interpreted separately in epithelial and stromal samples. Results: Epithelial MMP-2 expression was strong in 5%, moderate in 20%, weak in 25% and negative in 50% of the tumors, with high epithelial MMP-2 expression significantly associated in univariate survival analysis with advanced stage, poor grade and poor survival. Stromal MMP-2 expression was strong in 0%, moderate in 14%, weak in 70% and negative in 16% of the cases, and did not significantly correlate with patient survival. Conclusion: Epithelial MMP-2 correlates with advanced tumor stage and grade, but is not an independent predictor of survival.
Alkuperäiskielienglanti
LehtiOncology
Vuosikerta71
Numero1-2
Sivut61-68
Sivumäärä8
ISSN0030-2414
DOI - pysyväislinkit
TilaJulkaistu - 2006
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lisätietoja

Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print-Electronic Citation processed from: Print; NLM Journal Code: ohw, 0135054; CAS Registry/EC Number/Name of Substance: EC 3-4-24-24 (Matrix Metalloproteinase 2).; Electronic Date of Publication: 20070321; Entry Date: 20070522

M1 - Journal Article
Volume:
Proceeding volume:

Tieteenalat

  • IM
  • Adenocarcinoma/en [Enzymology]
  • Adenocarcinoma/pa [Pathology]
  • Adult
  • Aged
  • Carcinoma, Pancreatic Ductal/en [Enzymology]
  • Carcinoma, Pancreatic Ductal/pa [Pathology]
  • Female
  • Humans
  • Lymphatic Metastasis/pa [Pathology]
  • Matrix Metalloproteinase 2/me [Metabolism]
  • Middle Aged
  • Neoplasm Invasiveness/pa [Pathology]
  • Neoplasms, Glandular and Epithelial/en [Enzymology]
  • Neoplasms, Glandular and Epithelial/pa [Pathology]
  • Pancreatic Neoplasms/en [Enzymology]
  • Pancreatic Neoplasms/pa [Pathology]
  • Prognosis
  • Stromal Cells/en [Enzymology]
  • Stromal Cells/pa [Pathology]
  • Survival Rate

Lainaa tätä

@article{b154d7ea87114d4fab62dca4f84915b4,
title = "Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer.",
abstract = "Objective: Matrix metalloproteinases (MMPs) degrade extracellular matrix and are involved in tumor invasion and metastasis in various cancers. In pancreatic cancer, MMP-2 expression is upregulated and correlates with tumor recurrence. The aim of this study was to evaluate the prognostic significance of MMP-2 in pancreatic ductal adenocarcinoma. Methods: MMP-2 expression was assessed by immunohistochemistry in 127 patients operated on at Helsinki University Hospital from 1974 to 1998, with expression interpreted separately in epithelial and stromal samples. Results: Epithelial MMP-2 expression was strong in 5{\%}, moderate in 20{\%}, weak in 25{\%} and negative in 50{\%} of the tumors, with high epithelial MMP-2 expression significantly associated in univariate survival analysis with advanced stage, poor grade and poor survival. Stromal MMP-2 expression was strong in 0{\%}, moderate in 14{\%}, weak in 70{\%} and negative in 16{\%} of the cases, and did not significantly correlate with patient survival. Conclusion: Epithelial MMP-2 correlates with advanced tumor stage and grade, but is not an independent predictor of survival.",
keywords = "IM, Adenocarcinoma/en [Enzymology], Adenocarcinoma/pa [Pathology], Adult, Aged, Carcinoma, Pancreatic Ductal/en [Enzymology], Carcinoma, Pancreatic Ductal/pa [Pathology], Female, Humans, Lymphatic Metastasis/pa [Pathology], Matrix Metalloproteinase 2/me [Metabolism], Middle Aged, Neoplasm Invasiveness/pa [Pathology], Neoplasms, Glandular and Epithelial/en [Enzymology], Neoplasms, Glandular and Epithelial/pa [Pathology], Pancreatic Neoplasms/en [Enzymology], Pancreatic Neoplasms/pa [Pathology], Prognosis, Stromal Cells/en [Enzymology], Stromal Cells/pa [Pathology], Survival Rate",
author = "A. Juuti and J. Lundin and S. Nordling and J. Louhimo and C. Haglund",
note = "Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print-Electronic Citation processed from: Print; NLM Journal Code: ohw, 0135054; CAS Registry/EC Number/Name of Substance: EC 3-4-24-24 (Matrix Metalloproteinase 2).; Electronic Date of Publication: 20070321; Entry Date: 20070522 M1 - Journal Article Volume: Proceeding volume:",
year = "2006",
doi = "10.1159/000100988",
language = "English",
volume = "71",
pages = "61--68",
journal = "Oncology",
issn = "0030-2414",
publisher = "Karger",
number = "1-2",

}

Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer. / Juuti, A.; Lundin, J.; Nordling, S.; Louhimo, J.; Haglund, C.

julkaisussa: Oncology, Vuosikerta 71, Nro 1-2, 2006, s. 61-68.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer.

AU - Juuti, A.

AU - Lundin, J.

AU - Nordling, S.

AU - Louhimo, J.

AU - Haglund, C.

N1 - Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print-Electronic Citation processed from: Print; NLM Journal Code: ohw, 0135054; CAS Registry/EC Number/Name of Substance: EC 3-4-24-24 (Matrix Metalloproteinase 2).; Electronic Date of Publication: 20070321; Entry Date: 20070522 M1 - Journal Article Volume: Proceeding volume:

PY - 2006

Y1 - 2006

N2 - Objective: Matrix metalloproteinases (MMPs) degrade extracellular matrix and are involved in tumor invasion and metastasis in various cancers. In pancreatic cancer, MMP-2 expression is upregulated and correlates with tumor recurrence. The aim of this study was to evaluate the prognostic significance of MMP-2 in pancreatic ductal adenocarcinoma. Methods: MMP-2 expression was assessed by immunohistochemistry in 127 patients operated on at Helsinki University Hospital from 1974 to 1998, with expression interpreted separately in epithelial and stromal samples. Results: Epithelial MMP-2 expression was strong in 5%, moderate in 20%, weak in 25% and negative in 50% of the tumors, with high epithelial MMP-2 expression significantly associated in univariate survival analysis with advanced stage, poor grade and poor survival. Stromal MMP-2 expression was strong in 0%, moderate in 14%, weak in 70% and negative in 16% of the cases, and did not significantly correlate with patient survival. Conclusion: Epithelial MMP-2 correlates with advanced tumor stage and grade, but is not an independent predictor of survival.

AB - Objective: Matrix metalloproteinases (MMPs) degrade extracellular matrix and are involved in tumor invasion and metastasis in various cancers. In pancreatic cancer, MMP-2 expression is upregulated and correlates with tumor recurrence. The aim of this study was to evaluate the prognostic significance of MMP-2 in pancreatic ductal adenocarcinoma. Methods: MMP-2 expression was assessed by immunohistochemistry in 127 patients operated on at Helsinki University Hospital from 1974 to 1998, with expression interpreted separately in epithelial and stromal samples. Results: Epithelial MMP-2 expression was strong in 5%, moderate in 20%, weak in 25% and negative in 50% of the tumors, with high epithelial MMP-2 expression significantly associated in univariate survival analysis with advanced stage, poor grade and poor survival. Stromal MMP-2 expression was strong in 0%, moderate in 14%, weak in 70% and negative in 16% of the cases, and did not significantly correlate with patient survival. Conclusion: Epithelial MMP-2 correlates with advanced tumor stage and grade, but is not an independent predictor of survival.

KW - IM

KW - Adenocarcinoma/en [Enzymology]

KW - Adenocarcinoma/pa [Pathology]

KW - Adult

KW - Aged

KW - Carcinoma, Pancreatic Ductal/en [Enzymology]

KW - Carcinoma, Pancreatic Ductal/pa [Pathology]

KW - Female

KW - Humans

KW - Lymphatic Metastasis/pa [Pathology]

KW - Matrix Metalloproteinase 2/me [Metabolism]

KW - Middle Aged

KW - Neoplasm Invasiveness/pa [Pathology]

KW - Neoplasms, Glandular and Epithelial/en [Enzymology]

KW - Neoplasms, Glandular and Epithelial/pa [Pathology]

KW - Pancreatic Neoplasms/en [Enzymology]

KW - Pancreatic Neoplasms/pa [Pathology]

KW - Prognosis

KW - Stromal Cells/en [Enzymology]

KW - Stromal Cells/pa [Pathology]

KW - Survival Rate

U2 - 10.1159/000100988

DO - 10.1159/000100988

M3 - Article

VL - 71

SP - 61

EP - 68

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 1-2

ER -