Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree

Petra Pekkarinen, J Terwilliger, Per Erik Bredbacka, Jouko Lönnqvist, Leena Peltonen

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

An X-chromosomal predisposing locus to manic-depressive illness has been suggested since 1969 on the basis of the cosegregation of this trait in some families with phenotypic markers, such as color blindness, the glucose-6-phosphate dehydrogenase deficiency, and the coagulation factor IX deficiency. However, the conclusive evidence and the exact location of the putative X-chromosomal locus have remained controversial. We report here a linkage between DNA markers near the coagulation factor IX gene and bipolar disorder in an extended pedigree rising from the genetically isolated population of Finland. A distinct chromosomal haplotype covering a 20-cM region on Xq24-q27.1 could be demonstrated to segregate with bipolar disorder. These findings should encourage research groups to study extended family materials with Xq24-q27.1 markers to finally resolve the question of the X-chromosomal linkage of bipolar disorder.

Alkuperäiskielienglanti
LehtiGenome Research
Vuosikerta5
Sivut105-115
Sivumäärä11
ISSN1088-9051
TilaJulkaistu - 1995
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lainaa tätä

Pekkarinen, P., Terwilliger, J., Bredbacka, P. E., Lönnqvist, J., & Peltonen, L. (1995). Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree. Genome Research, 5, 105-115.
Pekkarinen, Petra ; Terwilliger, J ; Bredbacka, Per Erik ; Lönnqvist, Jouko ; Peltonen, Leena . / Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree. Julkaisussa: Genome Research. 1995 ; Vuosikerta 5. Sivut 105-115.
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title = "Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree",
abstract = "An X-chromosomal predisposing locus to manic-depressive illness has been suggested since 1969 on the basis of the cosegregation of this trait in some families with phenotypic markers, such as color blindness, the glucose-6-phosphate dehydrogenase deficiency, and the coagulation factor IX deficiency. However, the conclusive evidence and the exact location of the putative X-chromosomal locus have remained controversial. We report here a linkage between DNA markers near the coagulation factor IX gene and bipolar disorder in an extended pedigree rising from the genetically isolated population of Finland. A distinct chromosomal haplotype covering a 20-cM region on Xq24-q27.1 could be demonstrated to segregate with bipolar disorder. These findings should encourage research groups to study extended family materials with Xq24-q27.1 markers to finally resolve the question of the X-chromosomal linkage of bipolar disorder.",
keywords = "MANIC-DEPRESSIVE ILLNESS, X-CHROMOSOME MARKERS, MAJOR AFFECTIVE-DISORDER, COLOR-BLINDNESS, GENETIC-LINKAGE, CHRISTMAS DISEASE, FACTOR-IX, DNA, TRANSMISSION, PROBANDS",
author = "Petra Pekkarinen and J Terwilliger and Bredbacka, {Per Erik} and Jouko L{\"o}nnqvist and Leena Peltonen",
year = "1995",
language = "English",
volume = "5",
pages = "105--115",
journal = "Genome Research",
issn = "1088-9051",
publisher = "Cold Spring Harbor Laboratory in association with the Genetical Society of Great Britain",

}

Pekkarinen, P, Terwilliger, J, Bredbacka, PE, Lönnqvist, J & Peltonen, L 1995, 'Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree', Genome Research, Vuosikerta 5, Sivut 105-115.

Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree. / Pekkarinen, Petra ; Terwilliger, J ; Bredbacka, Per Erik ; Lönnqvist, Jouko; Peltonen, Leena .

julkaisussa: Genome Research, Vuosikerta 5, 1995, s. 105-115.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree

AU - Pekkarinen, Petra

AU - Terwilliger, J

AU - Bredbacka, Per Erik

AU - Lönnqvist, Jouko

AU - Peltonen, Leena

PY - 1995

Y1 - 1995

N2 - An X-chromosomal predisposing locus to manic-depressive illness has been suggested since 1969 on the basis of the cosegregation of this trait in some families with phenotypic markers, such as color blindness, the glucose-6-phosphate dehydrogenase deficiency, and the coagulation factor IX deficiency. However, the conclusive evidence and the exact location of the putative X-chromosomal locus have remained controversial. We report here a linkage between DNA markers near the coagulation factor IX gene and bipolar disorder in an extended pedigree rising from the genetically isolated population of Finland. A distinct chromosomal haplotype covering a 20-cM region on Xq24-q27.1 could be demonstrated to segregate with bipolar disorder. These findings should encourage research groups to study extended family materials with Xq24-q27.1 markers to finally resolve the question of the X-chromosomal linkage of bipolar disorder.

AB - An X-chromosomal predisposing locus to manic-depressive illness has been suggested since 1969 on the basis of the cosegregation of this trait in some families with phenotypic markers, such as color blindness, the glucose-6-phosphate dehydrogenase deficiency, and the coagulation factor IX deficiency. However, the conclusive evidence and the exact location of the putative X-chromosomal locus have remained controversial. We report here a linkage between DNA markers near the coagulation factor IX gene and bipolar disorder in an extended pedigree rising from the genetically isolated population of Finland. A distinct chromosomal haplotype covering a 20-cM region on Xq24-q27.1 could be demonstrated to segregate with bipolar disorder. These findings should encourage research groups to study extended family materials with Xq24-q27.1 markers to finally resolve the question of the X-chromosomal linkage of bipolar disorder.

KW - MANIC-DEPRESSIVE ILLNESS

KW - X-CHROMOSOME MARKERS

KW - MAJOR AFFECTIVE-DISORDER

KW - COLOR-BLINDNESS

KW - GENETIC-LINKAGE

KW - CHRISTMAS DISEASE

KW - FACTOR-IX

KW - DNA

KW - TRANSMISSION

KW - PROBANDS

M3 - Article

VL - 5

SP - 105

EP - 115

JO - Genome Research

JF - Genome Research

SN - 1088-9051

ER -