Gemfibrozil Impairs lmatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Alkuperäiskielienglanti
LehtiClinical Pharmacology and Therapeutics
Vuosikerta94
Numero3
Sivut383-393
Sivumäärä11
ISSN0009-9236
DOI - pysyväislinkit
TilaJulkaistu - syyskuuta 2013
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 317 Farmasia

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@article{55143e281000402ba49e900a58c8471d,
title = "Gemfibrozil Impairs lmatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite",
keywords = "CHRONIC MYELOID-LEUKEMIA, DRUG-DRUG INTERACTIONS, ST-JOHNS-WORT, PLASMA-CONCENTRATIONS, IMATINIB MESYLATE, HEALTHY-SUBJECTS, HEPATIC-UPTAKE, GLUCURONIDE INHIBIT, PROTEIN-BINDING, GIST PATIENTS, 317 Pharmacy",
author = "Filppula, {A. M.} and A. Tornio and Mikko Niemi and Neuvonen, {P. J.} and Backman, {J. T.}",
year = "2013",
month = "9",
doi = "10.1038/clpt.2013.92",
language = "English",
volume = "94",
pages = "383--393",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Wiley",
number = "3",

}

TY - JOUR

T1 - Gemfibrozil Impairs lmatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite

AU - Filppula, A. M.

AU - Tornio, A.

AU - Niemi, Mikko

AU - Neuvonen, P. J.

AU - Backman, J. T.

PY - 2013/9

Y1 - 2013/9

KW - CHRONIC MYELOID-LEUKEMIA

KW - DRUG-DRUG INTERACTIONS

KW - ST-JOHNS-WORT

KW - PLASMA-CONCENTRATIONS

KW - IMATINIB MESYLATE

KW - HEALTHY-SUBJECTS

KW - HEPATIC-UPTAKE

KW - GLUCURONIDE INHIBIT

KW - PROTEIN-BINDING

KW - GIST PATIENTS

KW - 317 Pharmacy

U2 - 10.1038/clpt.2013.92

DO - 10.1038/clpt.2013.92

M3 - Article

VL - 94

SP - 383

EP - 393

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 3

ER -