Genetic Determinants of Epigenetic Patterns: Providing Insight into Disease

The field of epigenetics and our understanding of the mechanisms that regulate the establishment, maintenance and heritability
of epigenetic patterns continue to grow at a remarkable rate. This information is providing increased understanding of the
role of epigenetic changes in disease, insight into the underlying causes of these epigenetic changes and revealing new avenues
for therapeutic intervention. Epigenetic modifiers are increasingly being pursued as therapeutic targets in a range of diseases,
with a number of agents targeting epigenetic modifications already proving effective in diseases such as cancer. Although it is
well established that DNA mutations and aberrant expression of epigenetic modifiers play a key role in disease, attention is now
turning to the interplay between genetic and epigenetic factors in complex disease etiology. The role of genetic variability in determining
epigenetic profiles, which can then be modified by environmental and stochastic factors, is becoming more apparent.
Understanding the interplay between genetic and epigenetic factors is likely to aid in identifying individuals most likely to benefit
from epigenetic therapies. This goal is coming closer to realization because of continual advances in laboratory and statistical
tools enabling improvements in the integration of genomic, epigenomic and phenotypic data.