Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Kyle J. Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Maegi, Michael E. Reschen, Anubha Mahajan, Adam Locke, N. William Rayner, Neil Robertson, Robert A. Scott, Inga Prokopenko, Laura J. Scott, Todd Green, Thomas Sparso, Dorothee Thuillier, Loic Yengo, Harald Grallert, Simone Wahl, Mattias FranbergRona J. Strawbridge, Hans Kestler, Himanshu Chheda, Lewin Eisele, Stefan Gustafsson, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Lu Qi, Lennart C. Karssen, Elisabeth M. van Leeuwen, Sara M. Willems, Man Li, Han Chen, Christian Fuchsberger, Phoenix Kwan, Clement Ma, Michael Linderman, Yingchang Lu, Soren K. Thomsen, Jana K. Rundle, Nicola L. Beer, Martijn van de Bunt, Anil Chalisey, Hyun Min Kang, Benjamin F. Voight, Goncalo R. Abecasis, Peter Almgren, Damiano Baldassarre, Beverley Balkau, Rafn Benediktsson, Matthias Blueher, Heiner Boeing, Lori L. Bonnycastle, Erwin P. Bottinger, Noel P. Burtt, Jason Carey, Guillaume Charpentier, Peter S. Chines, Marilyn C. Cornelis, David J. Couper, Andrew T. Crenshaw, Rob M. van Dam, Alex S. F. Doney, Mozhgan Dorkhan, Sarah Edkins, Johan G. Eriksson, Tonu Esko, Elodie Eury, Joao Fadista, Jason Flannick, Pierre Fontanillas, Caroline Fox, Paul W. Franks, Karl Gertow, Christian Gieger, Bruna Gigante, Omri Gottesman, George B. Grant, Niels Grarup, Christopher J. Groves, Maija Hassinen, Christian T. Have, Christian Herder, Oddgeir L. Holmen, Astradur B. Hreidarsson, Steve E. Humphries, David J. Hunter, Anne U. Jackson, Anna Jonsson, Marit E. Jorgensen, Torben Jorgensen, Wen-Hong L. Kao, Nicola D. Kerrison, Leena Kinnunen, Norman Klopp, Augustine Kong, Peter Kovacs, Peter Kraft, Jasmina Kravic, Cordelia Langford, Karin Leander, Liming Liang, Peter Lichtner, Cecilia M. Lindgren, Eero Lindholm, Allan Linneberg, Ching-Ti Liu, Stephane Lobbens, Jian'an Luan, Valeriya Lyssenko, Satu Mannisto, Olga McLeod, Julia Meyer, Evelin Mihailov, Ghazala Mirza, Thomas W. Muehleisen, Martina Mueller-Nurasyid, Carmen Navarro, Markus M. Noethen, Nikolay N. Oskolkov, Katharine R. Owen, Domenico Palli, Sonali Pechlivanis, Leena Peltonen, John R. B. Perry, Carl G. P. Platou, Michael Roden, Douglas Ruderfer, Denis Rybin, Yvonne T. van der Schouw, Bengt Sennblad, Gunnar Sigurdsson, Alena Stancakova, Gerald Steinbach, Petter Storm, Konstantin Strauch, Heather M. Stringham, Qi Sun, Barbara Thorand, Emmi Tikkanen, Anke Tonjes, Joseph Trakalo, Elena Tremoli, Tiinamaija Tuomi, Roman Wennauer, Steven Wiltshire, Andrew R. Wood, Eleftheria Zeggini, Ian Dunham, Ewan Birney, Lorenzo Pasquali, Jorge Ferrer, Ruth J. F. Loos, Josee Dupuis, Jose C. Florez, Eric Boerwinkle, James S. Pankow, Cornelia van Duijn, Eric Sijbrands, James B. Meigs, Frank B. Hu, Unnur Thorsteinsdottir, Kari Stefansson, Timo A. Lakka, Rainer Rauramaa, Michael Stumvoll, Nancy L. Pedersen, Lars Lind, Sirkka M. Keinanen-Kiukaanniemi, Eeva Korpi-Hyovalti, Timo E. Saaristo, Juha Saltevo, Johanna Kuusisto, Markku Laakso, Andres Metspalu, Raimund Erbel, Karl-Heinz Joecke, Susanne Moebus, Samuli Ripatti, Veikko Salomaa, Erik Ingelsson, Bernhard O. Boehm, Richard N. Bergman, Francis S. Collins, Karen L. Mohlke, Heikki Koistinen, Jaakko Tuomilehto, Kristian Hveem, Inger Njolstad, Panagiotis Deloukas, Peter J. Donnelly, Timothy M. Frayling, Andrew T. Hattersley, Ulf de Faire, Anders Hamsten, Thomas Illig, Annette Peters, Stephane Cauchi, Rob Sladek, Philippe Froguel, Torben Hansen, Oluf Pedersen, Andrew D. Morris, Collin N. A. Palmer, Sekar Kathiresan, Olle Melander, Peter M. Nilsson, Leif C. Groop, Ines Barroso, Claudia Langenberg, Nicholas J. Wareham, Christopher A. O'Callaghan, Anna L. Gloyn, David Altshuler, Michael Boehnke, Tanya M. Teslovich, Mark I. McCarthy, Andrew P. Morris, DIAbet Genetics Replication Meta-A

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Alkuperäiskielienglanti
LehtiNature Genetics
Vuosikerta47
Numero12
Sivut1415-1425
Sivumäärä14
ISSN1061-4036
DOI - pysyväislinkit
TilaJulkaistu - joulukuuta 2015
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3121 Sisätaudit
  • 3142 Kansanterveystiede, ympäristö ja työterveys

Lainaa tätä

Gaulton, K. J., Ferreira, T., Lee, Y., Raimondo, A., Maegi, R., Reschen, M. E., ... DIAbet Genetics Replication Meta-A (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47(12), 1415-1425. https://doi.org/10.1038/ng.3437
Gaulton, Kyle J. ; Ferreira, Teresa ; Lee, Yeji ; Raimondo, Anne ; Maegi, Reedik ; Reschen, Michael E. ; Mahajan, Anubha ; Locke, Adam ; Rayner, N. William ; Robertson, Neil ; Scott, Robert A. ; Prokopenko, Inga ; Scott, Laura J. ; Green, Todd ; Sparso, Thomas ; Thuillier, Dorothee ; Yengo, Loic ; Grallert, Harald ; Wahl, Simone ; Franberg, Mattias ; Strawbridge, Rona J. ; Kestler, Hans ; Chheda, Himanshu ; Eisele, Lewin ; Gustafsson, Stefan ; Steinthorsdottir, Valgerdur ; Thorleifsson, Gudmar ; Qi, Lu ; Karssen, Lennart C. ; van Leeuwen, Elisabeth M. ; Willems, Sara M. ; Li, Man ; Chen, Han ; Fuchsberger, Christian ; Kwan, Phoenix ; Ma, Clement ; Linderman, Michael ; Lu, Yingchang ; Thomsen, Soren K. ; Rundle, Jana K. ; Beer, Nicola L. ; van de Bunt, Martijn ; Chalisey, Anil ; Kang, Hyun Min ; Voight, Benjamin F. ; Abecasis, Goncalo R. ; Almgren, Peter ; Baldassarre, Damiano ; Balkau, Beverley ; Benediktsson, Rafn ; Blueher, Matthias ; Boeing, Heiner ; Bonnycastle, Lori L. ; Bottinger, Erwin P. ; Burtt, Noel P. ; Carey, Jason ; Charpentier, Guillaume ; Chines, Peter S. ; Cornelis, Marilyn C. ; Couper, David J. ; Crenshaw, Andrew T. ; van Dam, Rob M. ; Doney, Alex S. F. ; Dorkhan, Mozhgan ; Edkins, Sarah ; Eriksson, Johan G. ; Esko, Tonu ; Eury, Elodie ; Fadista, Joao ; Flannick, Jason ; Fontanillas, Pierre ; Fox, Caroline ; Franks, Paul W. ; Gertow, Karl ; Gieger, Christian ; Gigante, Bruna ; Gottesman, Omri ; Grant, George B. ; Grarup, Niels ; Groves, Christopher J. ; Hassinen, Maija ; Have, Christian T. ; Herder, Christian ; Holmen, Oddgeir L. ; Hreidarsson, Astradur B. ; Humphries, Steve E. ; Hunter, David J. ; Jackson, Anne U. ; Jonsson, Anna ; Jorgensen, Marit E. ; Jorgensen, Torben ; Kao, Wen-Hong L. ; Kerrison, Nicola D. ; Kinnunen, Leena ; Klopp, Norman ; Kong, Augustine ; Kovacs, Peter ; Kraft, Peter ; Kravic, Jasmina ; Langford, Cordelia ; Leander, Karin ; Liang, Liming ; Lichtner, Peter ; Lindgren, Cecilia M. ; Lindholm, Eero ; Linneberg, Allan ; Liu, Ching-Ti ; Lobbens, Stephane ; Luan, Jian'an ; Lyssenko, Valeriya ; Mannisto, Satu ; McLeod, Olga ; Meyer, Julia ; Mihailov, Evelin ; Mirza, Ghazala ; Muehleisen, Thomas W. ; Mueller-Nurasyid, Martina ; Navarro, Carmen ; Noethen, Markus M. ; Oskolkov, Nikolay N. ; Owen, Katharine R. ; Palli, Domenico ; Pechlivanis, Sonali ; Peltonen, Leena ; Perry, John R. B. ; Platou, Carl G. P. ; Roden, Michael ; Ruderfer, Douglas ; Rybin, Denis ; van der Schouw, Yvonne T. ; Sennblad, Bengt ; Sigurdsson, Gunnar ; Stancakova, Alena ; Steinbach, Gerald ; Storm, Petter ; Strauch, Konstantin ; Stringham, Heather M. ; Sun, Qi ; Thorand, Barbara ; Tikkanen, Emmi ; Tonjes, Anke ; Trakalo, Joseph ; Tremoli, Elena ; Tuomi, Tiinamaija ; Wennauer, Roman ; Wiltshire, Steven ; Wood, Andrew R. ; Zeggini, Eleftheria ; Dunham, Ian ; Birney, Ewan ; Pasquali, Lorenzo ; Ferrer, Jorge ; Loos, Ruth J. F. ; Dupuis, Josee ; Florez, Jose C. ; Boerwinkle, Eric ; Pankow, James S. ; van Duijn, Cornelia ; Sijbrands, Eric ; Meigs, James B. ; Hu, Frank B. ; Thorsteinsdottir, Unnur ; Stefansson, Kari ; Lakka, Timo A. ; Rauramaa, Rainer ; Stumvoll, Michael ; Pedersen, Nancy L. ; Lind, Lars ; Keinanen-Kiukaanniemi, Sirkka M. ; Korpi-Hyovalti, Eeva ; Saaristo, Timo E. ; Saltevo, Juha ; Kuusisto, Johanna ; Laakso, Markku ; Metspalu, Andres ; Erbel, Raimund ; Joecke, Karl-Heinz ; Moebus, Susanne ; Ripatti, Samuli ; Salomaa, Veikko ; Ingelsson, Erik ; Boehm, Bernhard O. ; Bergman, Richard N. ; Collins, Francis S. ; Mohlke, Karen L. ; Koistinen, Heikki ; Tuomilehto, Jaakko ; Hveem, Kristian ; Njolstad, Inger ; Deloukas, Panagiotis ; Donnelly, Peter J. ; Frayling, Timothy M. ; Hattersley, Andrew T. ; de Faire, Ulf ; Hamsten, Anders ; Illig, Thomas ; Peters, Annette ; Cauchi, Stephane ; Sladek, Rob ; Froguel, Philippe ; Hansen, Torben ; Pedersen, Oluf ; Morris, Andrew D. ; Palmer, Collin N. A. ; Kathiresan, Sekar ; Melander, Olle ; Nilsson, Peter M. ; Groop, Leif C. ; Barroso, Ines ; Langenberg, Claudia ; Wareham, Nicholas J. ; O'Callaghan, Christopher A. ; Gloyn, Anna L. ; Altshuler, David ; Boehnke, Michael ; Teslovich, Tanya M. ; McCarthy, Mark I. ; Morris, Andrew P. ; DIAbet Genetics Replication Meta-A. / Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Julkaisussa: Nature Genetics. 2015 ; Vuosikerta 47, Nro 12. Sivut 1415-1425.
@article{c404c304669148e3aaa034dc7f3a236d,
title = "Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci",
keywords = "LARGE-SCALE ASSOCIATION, HUMAN PANCREATIC-ISLETS, WIDE ASSOCIATION, BETA-CELL, TRANSCRIPTION FACTORS, GLUCOSE-HOMEOSTASIS, GENOTYPE IMPUTATION, INSULIN-SECRETION, COMMON VARIANTS, GLYCEMIC TRAITS, 3121 Internal medicine, 3142 Public health care science, environmental and occupational health",
author = "Gaulton, {Kyle J.} and Teresa Ferreira and Yeji Lee and Anne Raimondo and Reedik Maegi and Reschen, {Michael E.} and Anubha Mahajan and Adam Locke and Rayner, {N. William} and Neil Robertson and Scott, {Robert A.} and Inga Prokopenko and Scott, {Laura J.} and Todd Green and Thomas Sparso and Dorothee Thuillier and Loic Yengo and Harald Grallert and Simone Wahl and Mattias Franberg and Strawbridge, {Rona J.} and Hans Kestler and Himanshu Chheda and Lewin Eisele and Stefan Gustafsson and Valgerdur Steinthorsdottir and Gudmar Thorleifsson and Lu Qi and Karssen, {Lennart C.} and {van Leeuwen}, {Elisabeth M.} and Willems, {Sara M.} and Man Li and Han Chen and Christian Fuchsberger and Phoenix Kwan and Clement Ma and Michael Linderman and Yingchang Lu and Thomsen, {Soren K.} and Rundle, {Jana K.} and Beer, {Nicola L.} and {van de Bunt}, Martijn and Anil Chalisey and Kang, {Hyun Min} and Voight, {Benjamin F.} and Abecasis, {Goncalo R.} and Peter Almgren and Damiano Baldassarre and Beverley Balkau and Rafn Benediktsson and Matthias Blueher and Heiner Boeing and Bonnycastle, {Lori L.} and Bottinger, {Erwin P.} and Burtt, {Noel P.} and Jason Carey and Guillaume Charpentier and Chines, {Peter S.} and Cornelis, {Marilyn C.} and Couper, {David J.} and Crenshaw, {Andrew T.} and {van Dam}, {Rob M.} and Doney, {Alex S. F.} and Mozhgan Dorkhan and Sarah Edkins and Eriksson, {Johan G.} and Tonu Esko and Elodie Eury and Joao Fadista and Jason Flannick and Pierre Fontanillas and Caroline Fox and Franks, {Paul W.} and Karl Gertow and Christian Gieger and Bruna Gigante and Omri Gottesman and Grant, {George B.} and Niels Grarup and Groves, {Christopher J.} and Maija Hassinen and Have, {Christian T.} and Christian Herder and Holmen, {Oddgeir L.} and Hreidarsson, {Astradur B.} and Humphries, {Steve E.} and Hunter, {David J.} and Jackson, {Anne U.} and Anna Jonsson and Jorgensen, {Marit E.} and Torben Jorgensen and Kao, {Wen-Hong L.} and Kerrison, {Nicola D.} and Leena Kinnunen and Norman Klopp and Augustine Kong and Peter Kovacs and Peter Kraft and Jasmina Kravic and Cordelia Langford and Karin Leander and Liming Liang and Peter Lichtner and Lindgren, {Cecilia M.} and Eero Lindholm and Allan Linneberg and Ching-Ti Liu and Stephane Lobbens and Jian'an Luan and Valeriya Lyssenko and Satu Mannisto and Olga McLeod and Julia Meyer and Evelin Mihailov and Ghazala Mirza and Muehleisen, {Thomas W.} and Martina Mueller-Nurasyid and Carmen Navarro and Noethen, {Markus M.} and Oskolkov, {Nikolay N.} and Owen, {Katharine R.} and Domenico Palli and Sonali Pechlivanis and Leena Peltonen and Perry, {John R. B.} and Platou, {Carl G. P.} and Michael Roden and Douglas Ruderfer and Denis Rybin and {van der Schouw}, {Yvonne T.} and Bengt Sennblad and Gunnar Sigurdsson and Alena Stancakova and Gerald Steinbach and Petter Storm and Konstantin Strauch and Stringham, {Heather M.} and Qi Sun and Barbara Thorand and Emmi Tikkanen and Anke Tonjes and Joseph Trakalo and Elena Tremoli and Tiinamaija Tuomi and Roman Wennauer and Steven Wiltshire and Wood, {Andrew R.} and Eleftheria Zeggini and Ian Dunham and Ewan Birney and Lorenzo Pasquali and Jorge Ferrer and Loos, {Ruth J. F.} and Josee Dupuis and Florez, {Jose C.} and Eric Boerwinkle and Pankow, {James S.} and {van Duijn}, Cornelia and Eric Sijbrands and Meigs, {James B.} and Hu, {Frank B.} and Unnur Thorsteinsdottir and Kari Stefansson and Lakka, {Timo A.} and Rainer Rauramaa and Michael Stumvoll and Pedersen, {Nancy L.} and Lars Lind and Keinanen-Kiukaanniemi, {Sirkka M.} and Eeva Korpi-Hyovalti and Saaristo, {Timo E.} and Juha Saltevo and Johanna Kuusisto and Markku Laakso and Andres Metspalu and Raimund Erbel and Karl-Heinz Joecke and Susanne Moebus and Samuli Ripatti and Veikko Salomaa and Erik Ingelsson and Boehm, {Bernhard O.} and Bergman, {Richard N.} and Collins, {Francis S.} and Mohlke, {Karen L.} and Heikki Koistinen and Jaakko Tuomilehto and Kristian Hveem and Inger Njolstad and Panagiotis Deloukas and Donnelly, {Peter J.} and Frayling, {Timothy M.} and Hattersley, {Andrew T.} and {de Faire}, Ulf and Anders Hamsten and Thomas Illig and Annette Peters and Stephane Cauchi and Rob Sladek and Philippe Froguel and Torben Hansen and Oluf Pedersen and Morris, {Andrew D.} and Palmer, {Collin N. A.} and Sekar Kathiresan and Olle Melander and Nilsson, {Peter M.} and Groop, {Leif C.} and Ines Barroso and Claudia Langenberg and Wareham, {Nicholas J.} and O'Callaghan, {Christopher A.} and Gloyn, {Anna L.} and David Altshuler and Michael Boehnke and Teslovich, {Tanya M.} and McCarthy, {Mark I.} and Morris, {Andrew P.} and {DIAbet Genetics Replication Meta-A}",
year = "2015",
month = "12",
doi = "10.1038/ng.3437",
language = "English",
volume = "47",
pages = "1415--1425",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "12",

}

Gaulton, KJ, Ferreira, T, Lee, Y, Raimondo, A, Maegi, R, Reschen, ME, Mahajan, A, Locke, A, Rayner, NW, Robertson, N, Scott, RA, Prokopenko, I, Scott, LJ, Green, T, Sparso, T, Thuillier, D, Yengo, L, Grallert, H, Wahl, S, Franberg, M, Strawbridge, RJ, Kestler, H, Chheda, H, Eisele, L, Gustafsson, S, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Karssen, LC, van Leeuwen, EM, Willems, SM, Li, M, Chen, H, Fuchsberger, C, Kwan, P, Ma, C, Linderman, M, Lu, Y, Thomsen, SK, Rundle, JK, Beer, NL, van de Bunt, M, Chalisey, A, Kang, HM, Voight, BF, Abecasis, GR, Almgren, P, Baldassarre, D, Balkau, B, Benediktsson, R, Blueher, M, Boeing, H, Bonnycastle, LL, Bottinger, EP, Burtt, NP, Carey, J, Charpentier, G, Chines, PS, Cornelis, MC, Couper, DJ, Crenshaw, AT, van Dam, RM, Doney, ASF, Dorkhan, M, Edkins, S, Eriksson, JG, Esko, T, Eury, E, Fadista, J, Flannick, J, Fontanillas, P, Fox, C, Franks, PW, Gertow, K, Gieger, C, Gigante, B, Gottesman, O, Grant, GB, Grarup, N, Groves, CJ, Hassinen, M, Have, CT, Herder, C, Holmen, OL, Hreidarsson, AB, Humphries, SE, Hunter, DJ, Jackson, AU, Jonsson, A, Jorgensen, ME, Jorgensen, T, Kao, W-HL, Kerrison, ND, Kinnunen, L, Klopp, N, Kong, A, Kovacs, P, Kraft, P, Kravic, J, Langford, C, Leander, K, Liang, L, Lichtner, P, Lindgren, CM, Lindholm, E, Linneberg, A, Liu, C-T, Lobbens, S, Luan, J, Lyssenko, V, Mannisto, S, McLeod, O, Meyer, J, Mihailov, E, Mirza, G, Muehleisen, TW, Mueller-Nurasyid, M, Navarro, C, Noethen, MM, Oskolkov, NN, Owen, KR, Palli, D, Pechlivanis, S, Peltonen, L, Perry, JRB, Platou, CGP, Roden, M, Ruderfer, D, Rybin, D, van der Schouw, YT, Sennblad, B, Sigurdsson, G, Stancakova, A, Steinbach, G, Storm, P, Strauch, K, Stringham, HM, Sun, Q, Thorand, B, Tikkanen, E, Tonjes, A, Trakalo, J, Tremoli, E, Tuomi, T, Wennauer, R, Wiltshire, S, Wood, AR, Zeggini, E, Dunham, I, Birney, E, Pasquali, L, Ferrer, J, Loos, RJF, Dupuis, J, Florez, JC, Boerwinkle, E, Pankow, JS, van Duijn, C, Sijbrands, E, Meigs, JB, Hu, FB, Thorsteinsdottir, U, Stefansson, K, Lakka, TA, Rauramaa, R, Stumvoll, M, Pedersen, NL, Lind, L, Keinanen-Kiukaanniemi, SM, Korpi-Hyovalti, E, Saaristo, TE, Saltevo, J, Kuusisto, J, Laakso, M, Metspalu, A, Erbel, R, Joecke, K-H, Moebus, S, Ripatti, S, Salomaa, V, Ingelsson, E, Boehm, BO, Bergman, RN, Collins, FS, Mohlke, KL, Koistinen, H, Tuomilehto, J, Hveem, K, Njolstad, I, Deloukas, P, Donnelly, PJ, Frayling, TM, Hattersley, AT, de Faire, U, Hamsten, A, Illig, T, Peters, A, Cauchi, S, Sladek, R, Froguel, P, Hansen, T, Pedersen, O, Morris, AD, Palmer, CNA, Kathiresan, S, Melander, O, Nilsson, PM, Groop, LC, Barroso, I, Langenberg, C, Wareham, NJ, O'Callaghan, CA, Gloyn, AL, Altshuler, D, Boehnke, M, Teslovich, TM, McCarthy, MI, Morris, AP & DIAbet Genetics Replication Meta-A 2015, 'Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci', Nature Genetics, Vuosikerta 47, Nro 12, Sivut 1415-1425. https://doi.org/10.1038/ng.3437

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. / Gaulton, Kyle J.; Ferreira, Teresa; Lee, Yeji; Raimondo, Anne; Maegi, Reedik; Reschen, Michael E.; Mahajan, Anubha; Locke, Adam; Rayner, N. William; Robertson, Neil; Scott, Robert A.; Prokopenko, Inga; Scott, Laura J.; Green, Todd; Sparso, Thomas; Thuillier, Dorothee; Yengo, Loic; Grallert, Harald; Wahl, Simone; Franberg, Mattias; Strawbridge, Rona J.; Kestler, Hans; Chheda, Himanshu; Eisele, Lewin; Gustafsson, Stefan; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Qi, Lu; Karssen, Lennart C.; van Leeuwen, Elisabeth M.; Willems, Sara M.; Li, Man; Chen, Han; Fuchsberger, Christian; Kwan, Phoenix; Ma, Clement; Linderman, Michael; Lu, Yingchang; Thomsen, Soren K.; Rundle, Jana K.; Beer, Nicola L.; van de Bunt, Martijn; Chalisey, Anil; Kang, Hyun Min; Voight, Benjamin F.; Abecasis, Goncalo R.; Almgren, Peter; Baldassarre, Damiano; Balkau, Beverley; Benediktsson, Rafn; Blueher, Matthias; Boeing, Heiner; Bonnycastle, Lori L.; Bottinger, Erwin P.; Burtt, Noel P.; Carey, Jason; Charpentier, Guillaume; Chines, Peter S.; Cornelis, Marilyn C.; Couper, David J.; Crenshaw, Andrew T.; van Dam, Rob M.; Doney, Alex S. F.; Dorkhan, Mozhgan; Edkins, Sarah; Eriksson, Johan G.; Esko, Tonu; Eury, Elodie; Fadista, Joao; Flannick, Jason; Fontanillas, Pierre; Fox, Caroline; Franks, Paul W.; Gertow, Karl; Gieger, Christian; Gigante, Bruna; Gottesman, Omri; Grant, George B.; Grarup, Niels; Groves, Christopher J.; Hassinen, Maija; Have, Christian T.; Herder, Christian; Holmen, Oddgeir L.; Hreidarsson, Astradur B.; Humphries, Steve E.; Hunter, David J.; Jackson, Anne U.; Jonsson, Anna; Jorgensen, Marit E.; Jorgensen, Torben; Kao, Wen-Hong L.; Kerrison, Nicola D.; Kinnunen, Leena; Klopp, Norman; Kong, Augustine; Kovacs, Peter; Kraft, Peter; Kravic, Jasmina; Langford, Cordelia; Leander, Karin; Liang, Liming; Lichtner, Peter; Lindgren, Cecilia M.; Lindholm, Eero; Linneberg, Allan; Liu, Ching-Ti; Lobbens, Stephane; Luan, Jian'an; Lyssenko, Valeriya; Mannisto, Satu; McLeod, Olga; Meyer, Julia; Mihailov, Evelin; Mirza, Ghazala; Muehleisen, Thomas W.; Mueller-Nurasyid, Martina; Navarro, Carmen; Noethen, Markus M.; Oskolkov, Nikolay N.; Owen, Katharine R.; Palli, Domenico; Pechlivanis, Sonali; Peltonen, Leena; Perry, John R. B.; Platou, Carl G. P.; Roden, Michael; Ruderfer, Douglas; Rybin, Denis; van der Schouw, Yvonne T.; Sennblad, Bengt; Sigurdsson, Gunnar; Stancakova, Alena; Steinbach, Gerald; Storm, Petter; Strauch, Konstantin; Stringham, Heather M.; Sun, Qi; Thorand, Barbara; Tikkanen, Emmi; Tonjes, Anke; Trakalo, Joseph; Tremoli, Elena; Tuomi, Tiinamaija; Wennauer, Roman; Wiltshire, Steven; Wood, Andrew R.; Zeggini, Eleftheria; Dunham, Ian; Birney, Ewan; Pasquali, Lorenzo; Ferrer, Jorge; Loos, Ruth J. F.; Dupuis, Josee; Florez, Jose C.; Boerwinkle, Eric; Pankow, James S.; van Duijn, Cornelia; Sijbrands, Eric; Meigs, James B.; Hu, Frank B.; Thorsteinsdottir, Unnur; Stefansson, Kari; Lakka, Timo A.; Rauramaa, Rainer; Stumvoll, Michael; Pedersen, Nancy L.; Lind, Lars; Keinanen-Kiukaanniemi, Sirkka M.; Korpi-Hyovalti, Eeva; Saaristo, Timo E.; Saltevo, Juha; Kuusisto, Johanna; Laakso, Markku; Metspalu, Andres; Erbel, Raimund; Joecke, Karl-Heinz; Moebus, Susanne; Ripatti, Samuli; Salomaa, Veikko; Ingelsson, Erik; Boehm, Bernhard O.; Bergman, Richard N.; Collins, Francis S.; Mohlke, Karen L.; Koistinen, Heikki; Tuomilehto, Jaakko; Hveem, Kristian; Njolstad, Inger; Deloukas, Panagiotis; Donnelly, Peter J.; Frayling, Timothy M.; Hattersley, Andrew T.; de Faire, Ulf; Hamsten, Anders; Illig, Thomas; Peters, Annette; Cauchi, Stephane; Sladek, Rob; Froguel, Philippe; Hansen, Torben; Pedersen, Oluf; Morris, Andrew D.; Palmer, Collin N. A.; Kathiresan, Sekar; Melander, Olle; Nilsson, Peter M.; Groop, Leif C.; Barroso, Ines; Langenberg, Claudia; Wareham, Nicholas J.; O'Callaghan, Christopher A.; Gloyn, Anna L.; Altshuler, David; Boehnke, Michael; Teslovich, Tanya M.; McCarthy, Mark I.; Morris, Andrew P.; DIAbet Genetics Replication Meta-A.

julkaisussa: Nature Genetics, Vuosikerta 47, Nro 12, 12.2015, s. 1415-1425.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

AU - Gaulton, Kyle J.

AU - Ferreira, Teresa

AU - Lee, Yeji

AU - Raimondo, Anne

AU - Maegi, Reedik

AU - Reschen, Michael E.

AU - Mahajan, Anubha

AU - Locke, Adam

AU - Rayner, N. William

AU - Robertson, Neil

AU - Scott, Robert A.

AU - Prokopenko, Inga

AU - Scott, Laura J.

AU - Green, Todd

AU - Sparso, Thomas

AU - Thuillier, Dorothee

AU - Yengo, Loic

AU - Grallert, Harald

AU - Wahl, Simone

AU - Franberg, Mattias

AU - Strawbridge, Rona J.

AU - Kestler, Hans

AU - Chheda, Himanshu

AU - Eisele, Lewin

AU - Gustafsson, Stefan

AU - Steinthorsdottir, Valgerdur

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AU - DIAbet Genetics Replication Meta-A

PY - 2015/12

Y1 - 2015/12

KW - LARGE-SCALE ASSOCIATION

KW - HUMAN PANCREATIC-ISLETS

KW - WIDE ASSOCIATION

KW - BETA-CELL

KW - TRANSCRIPTION FACTORS

KW - GLUCOSE-HOMEOSTASIS

KW - GENOTYPE IMPUTATION

KW - INSULIN-SECRETION

KW - COMMON VARIANTS

KW - GLYCEMIC TRAITS

KW - 3121 Internal medicine

KW - 3142 Public health care science, environmental and occupational health

U2 - 10.1038/ng.3437

DO - 10.1038/ng.3437

M3 - Article

VL - 47

SP - 1415

EP - 1425

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 12

ER -

Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Maegi R, Reschen ME et al. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics. 2015 joulu;47(12):1415-1425. https://doi.org/10.1038/ng.3437