Genetic linkage findings for DSM-IV nicotine withdrawal in two populations

Michele L Pergadia, Arpana Agrawal, Anu Loukola, Grant W Montgomery, Ulla Broms, Scott F Saccone, Jen C Wang, Alexandre A Todorov, Kauko Heikkilä, Dixie J Statham, Anjali K Henders, Megan J Campbell, John P Rice, Richard D Todd, Andrew C Heath, Alison, M Goate, Leena Peltonen, Jaakko Kaprio, Nicholas G Martin, Pamela A. F Madden

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

"Nicotine withdrawal (NW) is both an important contributor to difficulty quitting cigarettes and because of mood-related withdrawal symptoms a problem of particular relevance to psychiatry. Twin-studies suggest that genetic factors influence NW (heritability = 45%). Only one previous linkage study has published findings on NW [Swan et al. (2006); Am J Med Genet Part B 141 B:354-360; LOD = 2.7; Chr. 6 at 159 cM]. As part of an international consortium, genome-wide scans (using over 360 autosomial microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N = 450 families) families ascertained from twin registries through index-cases with a lifetime history of cigarette smoking. The statistical approach used an affected-sib-pair design (at least two adult full siblings reported a history of DSM-IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores > 1.5 were found on two chromosomes: 6 (FIN: LOD = 1.93 at 75 cM) and I I at two different locations (FIN: LOD = 3.55 at 17 cM, and AUS: LOD = 1.68 with a COMB: LOD = 2.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (P = 0.013 with 1,000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: DRD4, TPH, TH, and CHRNA10. Other studies have reported that chromosome I I may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW. (C) 2009 Wiley-Liss, Inc."
Alkuperäiskielienglanti
LehtiAmerican journal of medical genetics. Part B, Neuropsychiatric genetics
Vuosikerta150B
Numero7
Sivut950-959
Sivumäärä10
ISSN1552-4841
DOI - pysyväislinkit
TilaJulkaistu - 2009
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 311 Peruslääketieteet
  • 312 Kliiniset lääketieteet
  • 318 Lääketieteen bioteknologia
  • 217 Lääketieteen tekniikka
  • 118 Biotieteet
  • 314 Terveystieteet

Lainaa tätä

Pergadia, Michele L ; Agrawal, Arpana ; Loukola, Anu ; Montgomery, Grant W ; Broms, Ulla ; Saccone, Scott F ; Wang, Jen C ; Todorov, Alexandre A ; Heikkilä, Kauko ; Statham, Dixie J ; Henders, Anjali K ; Campbell, Megan J ; Rice, John P ; Todd, Richard D ; Heath, Andrew C ; Goate, Alison, M ; Peltonen, Leena ; Kaprio, Jaakko ; Martin, Nicholas G ; Madden, Pamela A. F. / Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. Julkaisussa: American journal of medical genetics. Part B, Neuropsychiatric genetics. 2009 ; Vuosikerta 150B, Nro 7. Sivut 950-959.
@article{5460cdd320954435bf38fafd951dd6e0,
title = "Genetic linkage findings for DSM-IV nicotine withdrawal in two populations",
abstract = "{"}Nicotine withdrawal (NW) is both an important contributor to difficulty quitting cigarettes and because of mood-related withdrawal symptoms a problem of particular relevance to psychiatry. Twin-studies suggest that genetic factors influence NW (heritability = 45{\%}). Only one previous linkage study has published findings on NW [Swan et al. (2006); Am J Med Genet Part B 141 B:354-360; LOD = 2.7; Chr. 6 at 159 cM]. As part of an international consortium, genome-wide scans (using over 360 autosomial microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N = 450 families) families ascertained from twin registries through index-cases with a lifetime history of cigarette smoking. The statistical approach used an affected-sib-pair design (at least two adult full siblings reported a history of DSM-IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores > 1.5 were found on two chromosomes: 6 (FIN: LOD = 1.93 at 75 cM) and I I at two different locations (FIN: LOD = 3.55 at 17 cM, and AUS: LOD = 1.68 with a COMB: LOD = 2.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (P = 0.013 with 1,000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: DRD4, TPH, TH, and CHRNA10. Other studies have reported that chromosome I I may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW. (C) 2009 Wiley-Liss, Inc.{"}",
keywords = "311 Basic medicine, 312 Clinical medicine, 318 Medical biotechnology, 217 Medical engineering, 118 Biological sciences, 314 Health sciences",
author = "Pergadia, {Michele L} and Arpana Agrawal and Anu Loukola and Montgomery, {Grant W} and Ulla Broms and Saccone, {Scott F} and Wang, {Jen C} and Todorov, {Alexandre A} and Kauko Heikkil{\"a} and Statham, {Dixie J} and Henders, {Anjali K} and Campbell, {Megan J} and Rice, {John P} and Todd, {Richard D} and Heath, {Andrew C} and Goate, {Alison, M} and Leena Peltonen and Jaakko Kaprio and Martin, {Nicholas G} and Madden, {Pamela A. F}",
year = "2009",
doi = "10.1002/ajmg.b.30924",
language = "English",
volume = "150B",
pages = "950--959",
journal = "American journal of medical genetics. Part B, Neuropsychiatric genetics",
issn = "1552-4841",
publisher = "Wiley Blackwell",
number = "7",

}

Pergadia, ML, Agrawal, A, Loukola, A, Montgomery, GW, Broms, U, Saccone, SF, Wang, JC, Todorov, AA, Heikkilä, K, Statham, DJ, Henders, AK, Campbell, MJ, Rice, JP, Todd, RD, Heath, AC, Goate, AM, Peltonen, L, Kaprio, J, Martin, NG & Madden, PAF 2009, 'Genetic linkage findings for DSM-IV nicotine withdrawal in two populations', American journal of medical genetics. Part B, Neuropsychiatric genetics, Vuosikerta 150B, Nro 7, Sivut 950-959. https://doi.org/10.1002/ajmg.b.30924

Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. / Pergadia, Michele L; Agrawal, Arpana; Loukola, Anu; Montgomery, Grant W; Broms, Ulla; Saccone, Scott F; Wang, Jen C; Todorov, Alexandre A; Heikkilä, Kauko; Statham, Dixie J; Henders, Anjali K; Campbell, Megan J; Rice, John P; Todd, Richard D; Heath, Andrew C; Goate, Alison, M; Peltonen, Leena; Kaprio, Jaakko; Martin, Nicholas G; Madden, Pamela A. F.

julkaisussa: American journal of medical genetics. Part B, Neuropsychiatric genetics, Vuosikerta 150B, Nro 7, 2009, s. 950-959.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Genetic linkage findings for DSM-IV nicotine withdrawal in two populations

AU - Pergadia, Michele L

AU - Agrawal, Arpana

AU - Loukola, Anu

AU - Montgomery, Grant W

AU - Broms, Ulla

AU - Saccone, Scott F

AU - Wang, Jen C

AU - Todorov, Alexandre A

AU - Heikkilä, Kauko

AU - Statham, Dixie J

AU - Henders, Anjali K

AU - Campbell, Megan J

AU - Rice, John P

AU - Todd, Richard D

AU - Heath, Andrew C

AU - Goate, Alison, M

AU - Peltonen, Leena

AU - Kaprio, Jaakko

AU - Martin, Nicholas G

AU - Madden, Pamela A. F

PY - 2009

Y1 - 2009

N2 - "Nicotine withdrawal (NW) is both an important contributor to difficulty quitting cigarettes and because of mood-related withdrawal symptoms a problem of particular relevance to psychiatry. Twin-studies suggest that genetic factors influence NW (heritability = 45%). Only one previous linkage study has published findings on NW [Swan et al. (2006); Am J Med Genet Part B 141 B:354-360; LOD = 2.7; Chr. 6 at 159 cM]. As part of an international consortium, genome-wide scans (using over 360 autosomial microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N = 450 families) families ascertained from twin registries through index-cases with a lifetime history of cigarette smoking. The statistical approach used an affected-sib-pair design (at least two adult full siblings reported a history of DSM-IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores > 1.5 were found on two chromosomes: 6 (FIN: LOD = 1.93 at 75 cM) and I I at two different locations (FIN: LOD = 3.55 at 17 cM, and AUS: LOD = 1.68 with a COMB: LOD = 2.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (P = 0.013 with 1,000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: DRD4, TPH, TH, and CHRNA10. Other studies have reported that chromosome I I may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW. (C) 2009 Wiley-Liss, Inc."

AB - "Nicotine withdrawal (NW) is both an important contributor to difficulty quitting cigarettes and because of mood-related withdrawal symptoms a problem of particular relevance to psychiatry. Twin-studies suggest that genetic factors influence NW (heritability = 45%). Only one previous linkage study has published findings on NW [Swan et al. (2006); Am J Med Genet Part B 141 B:354-360; LOD = 2.7; Chr. 6 at 159 cM]. As part of an international consortium, genome-wide scans (using over 360 autosomial microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N = 450 families) families ascertained from twin registries through index-cases with a lifetime history of cigarette smoking. The statistical approach used an affected-sib-pair design (at least two adult full siblings reported a history of DSM-IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores > 1.5 were found on two chromosomes: 6 (FIN: LOD = 1.93 at 75 cM) and I I at two different locations (FIN: LOD = 3.55 at 17 cM, and AUS: LOD = 1.68 with a COMB: LOD = 2.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (P = 0.013 with 1,000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: DRD4, TPH, TH, and CHRNA10. Other studies have reported that chromosome I I may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW. (C) 2009 Wiley-Liss, Inc."

KW - 311 Basic medicine

KW - 312 Clinical medicine

KW - 318 Medical biotechnology

KW - 217 Medical engineering

KW - 118 Biological sciences

KW - 314 Health sciences

U2 - 10.1002/ajmg.b.30924

DO - 10.1002/ajmg.b.30924

M3 - Article

VL - 150B

SP - 950

EP - 959

JO - American journal of medical genetics. Part B, Neuropsychiatric genetics

JF - American journal of medical genetics. Part B, Neuropsychiatric genetics

SN - 1552-4841

IS - 7

ER -