Heritability of cognitive functions in families with bipolar disorder

Mervi Antila, Annamari Tuulio-Henriksson, Tuula Kieseppä, Pia Soronen, Outi Palo, Tiina Paunio, Jari Haukka, Timo Partonen, Jouko Lönnqvist, Tuula Paunio

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Abstrakti

    Bipolar disorder is highly heritable. Cognitive dysfunctions often observed in bipolar patients and their unaffected relatives implicate that these impairments maybe associated with genetic predisposition to bipolar disorder and thus fulfill the criteria of a valid endophenotype for the disorder. However, the most fundamental criterion, their heritability, has not been directly studied in any bipolar population. This population-based study estimated the heritability of cognitive functions in bipolar disorder. A comprehensive neuropsychological test battery and the Structured Clinical Interview for DSM-IV were administered to a population-based sample of 110 individuals from 52 families with bipolar disorder. Heritability of cognitive functions as assessed with neuropsychological. test scores were estimated using the Solar package. Significant additive heritabilities were found in verbal ability, executive functioning, and psychomotor processing speed. Genetic contribution was low to verbal learning functions. High heritability, in executive functioning and psychomotor processing speed suggest that these may be valid endophenotypic traits for genetic studies of bipolar disorder. (c) 2007 Wiley-Liss, Inc.
    Alkuperäiskielienglanti
    LehtiAmerican journal of medical genetics. Part B, Neuropsychiatric genetics
    Vuosikerta144
    Numero6
    Sivut802-808
    Sivumäärä7
    ISSN1552-4841
    DOI - pysyväislinkit
    TilaJulkaistu - 2007
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

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