Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia

Dale W Prebble; Vanja Voser; Safak Er; Irena Hlushchuk; Andrii Domanskyi; Mikko Airavaara; Merrick G Ekins; George D Mellick; Anthony R Carroll

doi:10.1016/j.rechem.2022.100302

Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia

Dale W Prebble, Vanja Voser, Safak Er, Irena Hlushchuk, Andrii Domanskyi, Mikko Airavaara, Merrick G Ekins, George D Mellick, Anthony R Carroll

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Abstrakti

During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract resulted in the isolation of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2) as the α-syn binder along with one new compound, hesperine (1), and five known compounds, indole-3-carboxaldehyde (3), (Z)-2'-demethylaplysinopsin (4), 2-amino-4'-hydroxyacetophenone (5), 4-hydroxybenzoic acid (6) and 4-hydroxybenzaldehyde (7). Herein, we report the structure elucidation of hesperine (1) and α-syn binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2).

Alkuperäiskieli	englanti
Artikkeli	100302
Lehti	Results in chemistry
Vuosikerta	4
Sivumäärä	4
DOI - pysyväislinkit	https://doi.org/10.1016/j.rechem.2022.100302
Tila	Julkaistu - tammik. 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

119 Muut luonnontieteet
116 Kemia
1182 Biokemia, solu- ja molekyylibiologia

Pääsy asiakirjaan

10.1016/j.rechem.2022.100302Lisenssi: CC BY

1-s2.0-S2211715622000212-mainLopullinen julkaistu versio, 929 KBLisenssi: CC BY

Siteeraa tätä

Prebble, D. W., Voser, V., Er, S., Hlushchuk, I., Domanskyi, A., Airavaara, M., Ekins, M. G., Mellick, G. D., & Carroll, A. R. (2022). Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia. Results in chemistry, 4, Artikkeli 100302. https://doi.org/10.1016/j.rechem.2022.100302

@article{0374de2169494c4a91c9ea00dfd596fd,

title = "Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia",

abstract = "During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract resulted in the isolation of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2) as the α-syn binder along with one new compound, hesperine (1), and five known compounds, indole-3-carboxaldehyde (3), (Z)-2'-demethylaplysinopsin (4), 2-amino-4'-hydroxyacetophenone (5), 4-hydroxybenzoic acid (6) and 4-hydroxybenzaldehyde (7). Herein, we report the structure elucidation of hesperine (1) and α-syn binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2).",

keywords = "119 Other natural sciences, 116 Chemical sciences, 1182 Biochemistry, cell and molecular biology, Amyloid, alpha-Synuclein, Clathria (Thalysias) cf. hesperia, Alkaloids, ALPHA-SYNUCLEIN, ALZHEIMERS-DISEASE, AGGREGATION, MECHANISM",

author = "Prebble, {Dale W} and Vanja Voser and Safak Er and Irena Hlushchuk and Andrii Domanskyi and Mikko Airavaara and Ekins, {Merrick G} and Mellick, {George D} and Carroll, {Anthony R}",

year = "2022",

month = jan,

doi = "10.1016/j.rechem.2022.100302",

language = "English",

volume = "4",

journal = "Results in chemistry",

issn = "2211-7156",

publisher = "Elsevier",

}

Prebble, DW, Voser, V, Er, S, Hlushchuk, I , Domanskyi, A , Airavaara, M, Ekins, MG, Mellick, GD & Carroll, AR 2022, 'Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia', Results in chemistry, Vuosikerta 4, 100302. https://doi.org/10.1016/j.rechem.2022.100302

Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia. / Prebble, Dale W; Voser, Vanja; Er, Safak et al.
julkaisussa: Results in chemistry, Vuosikerta 4, 100302, 01.2022.

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

TY - JOUR

T1 - Hesperine, a new imidazole alkaloid and α-synuclein binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine from the marine sponge Clathria (Thalysias) cf. hesperia

AU - Prebble, Dale W

AU - Voser, Vanja

AU - Er, Safak

AU - Hlushchuk, Irena

AU - Domanskyi, Andrii

AU - Airavaara, Mikko

AU - Ekins, Merrick G

AU - Mellick, George D

AU - Carroll, Anthony R

PY - 2022/1

Y1 - 2022/1

N2 - During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract resulted in the isolation of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2) as the α-syn binder along with one new compound, hesperine (1), and five known compounds, indole-3-carboxaldehyde (3), (Z)-2'-demethylaplysinopsin (4), 2-amino-4'-hydroxyacetophenone (5), 4-hydroxybenzoic acid (6) and 4-hydroxybenzaldehyde (7). Herein, we report the structure elucidation of hesperine (1) and α-syn binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2).

AB - During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract resulted in the isolation of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2) as the α-syn binder along with one new compound, hesperine (1), and five known compounds, indole-3-carboxaldehyde (3), (Z)-2'-demethylaplysinopsin (4), 2-amino-4'-hydroxyacetophenone (5), 4-hydroxybenzoic acid (6) and 4-hydroxybenzaldehyde (7). Herein, we report the structure elucidation of hesperine (1) and α-syn binding activity of 1-methyl-1,2,7,8-tetrahydro-2,8-dioxoadenosine (2).

KW - 119 Other natural sciences

KW - 116 Chemical sciences

KW - 1182 Biochemistry, cell and molecular biology

KW - Amyloid

KW - alpha-Synuclein

KW - Clathria (Thalysias) cf. hesperia

KW - Alkaloids

KW - ALPHA-SYNUCLEIN

KW - ALZHEIMERS-DISEASE

KW - AGGREGATION

KW - MECHANISM

U2 - 10.1016/j.rechem.2022.100302

DO - 10.1016/j.rechem.2022.100302

M3 - Article

SN - 2211-7156

VL - 4

JO - Results in chemistry

JF - Results in chemistry

M1 - 100302

ER -