Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Michele M. Nava; Yekaterina A. Miroshnikova; Leah C. Biggs; Daniel B. Whitefield; Franziska Metge; Jorge Boucas; Helena Vihinen; Eija Jokitalo; Xinping Li; Juan Manuel García Arcos; Bernd Hoffmann; Rudolf Merkel; Carien M. Niessen; Kris Noel Dahl; Sara A. Wickström

doi:10.1016/j.cell.2020.03.052

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Michele M. Nava, Yekaterina A. Miroshnikova, Leah C. Biggs, Daniel B. Whitefield, Franziska Metge, Jorge Boucas, Helena Vihinen, Eija Jokitalo, Xinping Li, Juan Manuel García Arcos, Bernd Hoffmann, Rudolf Merkel, Carien M. Niessen, Kris Noel Dahl, Sara A. Wickström

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Lehti	Cell
Vuosikerta	181
Numero	4
Sivut	800-+
Sivumäärä	40
ISSN	0092-8674
DOI - pysyväislinkit	https://doi.org/10.1016/j.cell.2020.03.052
Tila	Julkaistu - 14 toukok. 2020
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

1182 Biokemia, solu- ja molekyylibiologia

Pääsy asiakirjaan

10.1016/j.cell.2020.03.052

1-s2.0-S0092867420303457-mainKorjausvedos, 13,7 MBLisenssi: CC BY-NC-ND

Siteeraa tätä

Nava, M. M., Miroshnikova, Y. A., Biggs, L. C., Whitefield, D. B., Metge, F., Boucas, J., Vihinen, H., Jokitalo, E., Li, X., García Arcos, J. M., Hoffmann, B., Merkel, R., Niessen, C. M., Dahl, K. N., & Wickström, S. A. (2020). Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell, 181(4), 800-+. https://doi.org/10.1016/j.cell.2020.03.052

@article{965085d96b3541d0aefd872f96e63801,

title = "Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage",

keywords = "1182 Biochemistry, cell and molecular biology, stem cells, mechanotransduction, chromatin, heterochromatin, mechanoprotection, DNA damage, nuclear lamina, nuclear architecture, nuclear mechanics, CHROMATIN, DNA-DAMAGE, RECEPTOR, ELEMENTS, ALIGNMENT, ORIENTATION, ARCHITECTURE, STRAIN, MORPHOLOGY, PLASTICITY",

author = "Nava, {Michele M.} and Miroshnikova, {Yekaterina A.} and Biggs, {Leah C.} and Whitefield, {Daniel B.} and Franziska Metge and Jorge Boucas and Helena Vihinen and Eija Jokitalo and Xinping Li and {Garc{\'i}a Arcos}, {Juan Manuel} and Bernd Hoffmann and Rudolf Merkel and Niessen, {Carien M.} and Dahl, {Kris Noel} and Wickstr{\"o}m, {Sara A.}",

year = "2020",

month = may,

day = "14",

doi = "10.1016/j.cell.2020.03.052",

language = "English",

volume = "181",

pages = "800--+",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "4",

}

Nava, MM, Miroshnikova, YA, Biggs, LC, Whitefield, DB, Metge, F, Boucas, J, Vihinen, H , Jokitalo, E, Li, X, García Arcos, JM, Hoffmann, B, Merkel, R, Niessen, CM, Dahl, KN & Wickström, SA 2020, 'Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage', Cell, Vuosikerta 181, Nro 4, Sivut 800-+. https://doi.org/10.1016/j.cell.2020.03.052

TY - JOUR

T1 - Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

AU - Nava, Michele M.

AU - Miroshnikova, Yekaterina A.

AU - Biggs, Leah C.

AU - Whitefield, Daniel B.

AU - Metge, Franziska

AU - Boucas, Jorge

AU - Vihinen, Helena

AU - Jokitalo, Eija

AU - Li, Xinping

AU - García Arcos, Juan Manuel

AU - Hoffmann, Bernd

AU - Merkel, Rudolf

AU - Niessen, Carien M.

AU - Dahl, Kris Noel

AU - Wickström, Sara A.

PY - 2020/5/14

Y1 - 2020/5/14

KW - 1182 Biochemistry, cell and molecular biology

KW - stem cells

KW - mechanotransduction

KW - chromatin

KW - heterochromatin

KW - mechanoprotection

KW - DNA damage

KW - nuclear lamina

KW - nuclear architecture

KW - nuclear mechanics

KW - CHROMATIN

KW - DNA-DAMAGE

KW - RECEPTOR

KW - ELEMENTS

KW - ALIGNMENT

KW - ORIENTATION

KW - ARCHITECTURE

KW - STRAIN

KW - MORPHOLOGY

KW - PLASTICITY

U2 - 10.1016/j.cell.2020.03.052

DO - 10.1016/j.cell.2020.03.052

M3 - Article

VL - 181

SP - 800-+

JO - Cell

JF - Cell

SN - 0092-8674

IS - 4

ER -