High frequency of SNAIL-expressing cells confirms and predicts metastatic potential of phaeochromocytoma

Valtteri Häyry, Kaisa Salmenkivi, Johanna Arola, Päivi Heikkilä, Caj Haglund, Hannu Sariola

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Abstrakti

    Phaeochromocytomas are uncommon tumours of adrenal or extra-adrenal chromaffin tissue. About 2-26% of these have been reported to metastasize, but, on histological criteria, it is virtually impossible to predict malignant behaviour of the tumour Using immunohistochemistry, we analysed the protein expression of SNAIL, a zinc-finger transcription factor, in a series of 50 phaeochromocytoma specimens from 42 patients. We found that SNAIL-expressing cells are frequent in metastatic primary tumours and their metastases, whereas in tumours without metastases, SNAIL expression is commonly absent We conclude that the expression of SNAIL may be of use in predicting the metastatic potential of phaeochromocytoma. Endocrine-Related Cancer (2009) 16 1211-1218
    Alkuperäiskielienglanti
    LehtiEndocrine - Related Cancer
    Vuosikerta16
    Numero4
    Sivut1211-1218
    Sivumäärä8
    ISSN1351-0088
    DOI - pysyväislinkit
    TilaJulkaistu - 2009
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

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