High-resolution CT by diffraction-enhanced x-ray imaging

mapping of breast tissue samples and comparison with their histo-pathology

Alberto Bravin, Jani Keyriläinen, Manuel Fernandez, Stefan Fiedler, Christian Nemoz, Marja-Liisa Karjalainen-Lindsberg, Mikko Tenhunen, Pekka Virkkunen, Marjut Leidenius, Karl von Smitten, Petri Sipilä, Pekka Suortti

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

The aim of this study was to introduce high-resolution computed tomography (CT) of breast tumours using the diffraction-enhanced x-ray imaging (DEI) technique and to compare results with radiological and histo-pathological examinations. X-ray CT images of tumour-bearing breast tissue samples were acquired by monochromatic synchrotron radiation (SR). Due to the narrow beam and a large sample-to-detector distance scattering is rejected in the absorption contrast images (SR-CT). Large contrast enhancement is achieved by the use of the DEI-CT method, where the effects of refraction and scatter rejection are analysed by crystal optics. Clinical mammograms and CT images were recorded as reference material for a radiological examination. Three malignant and benign samples were studied in detail. Their radiographs were compared with optical images of stained histological sections. The DEI-CT images map accurately the morphology of the samples, including collagen strands and micro-calcifications of dimensions less than 0.1 mm. Histo-pathological examination and reading of the radiographs were done independently, and the conclusions were in general agreement. High-resolution DEI-CT images show strong contrast and permit visualization of details invisible in clinical radiographs. The radiation dose may be reduced by an order of magnitude without compromising image quality, which would make possible clinical in vivo DEI-CT with future compact SR sources.
Alkuperäiskielienglanti
LehtiPhysics in Medicine and Biology
Vuosikerta52
Numero8
Sivut2197- 2211
Sivumäärä15
ISSN0031-9155
DOI - pysyväislinkit
TilaJulkaistu - 2007
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lainaa tätä

Bravin, Alberto ; Keyriläinen, Jani ; Fernandez, Manuel ; Fiedler, Stefan ; Nemoz, Christian ; Karjalainen-Lindsberg, Marja-Liisa ; Tenhunen, Mikko ; Virkkunen, Pekka ; Leidenius, Marjut ; Smitten, Karl von ; Sipilä, Petri ; Suortti, Pekka. / High-resolution CT by diffraction-enhanced x-ray imaging : mapping of breast tissue samples and comparison with their histo-pathology. Julkaisussa: Physics in Medicine and Biology. 2007 ; Vuosikerta 52, Nro 8. Sivut 2197- 2211.
@article{e81f7d834afc45d5983a442d88057ebf,
title = "High-resolution CT by diffraction-enhanced x-ray imaging: mapping of breast tissue samples and comparison with their histo-pathology",
abstract = "The aim of this study was to introduce high-resolution computed tomography (CT) of breast tumours using the diffraction-enhanced x-ray imaging (DEI) technique and to compare results with radiological and histo-pathological examinations. X-ray CT images of tumour-bearing breast tissue samples were acquired by monochromatic synchrotron radiation (SR). Due to the narrow beam and a large sample-to-detector distance scattering is rejected in the absorption contrast images (SR-CT). Large contrast enhancement is achieved by the use of the DEI-CT method, where the effects of refraction and scatter rejection are analysed by crystal optics. Clinical mammograms and CT images were recorded as reference material for a radiological examination. Three malignant and benign samples were studied in detail. Their radiographs were compared with optical images of stained histological sections. The DEI-CT images map accurately the morphology of the samples, including collagen strands and micro-calcifications of dimensions less than 0.1 mm. Histo-pathological examination and reading of the radiographs were done independently, and the conclusions were in general agreement. High-resolution DEI-CT images show strong contrast and permit visualization of details invisible in clinical radiographs. The radiation dose may be reduced by an order of magnitude without compromising image quality, which would make possible clinical in vivo DEI-CT with future compact SR sources.",
author = "Alberto Bravin and Jani Keyril{\"a}inen and Manuel Fernandez and Stefan Fiedler and Christian Nemoz and Marja-Liisa Karjalainen-Lindsberg and Mikko Tenhunen and Pekka Virkkunen and Marjut Leidenius and Smitten, {Karl von} and Petri Sipil{\"a} and Pekka Suortti",
year = "2007",
doi = "10.1088/0031-9155/52/8/011",
language = "English",
volume = "52",
pages = "2197-- 2211",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing",
number = "8",

}

Bravin, A, Keyriläinen, J, Fernandez, M, Fiedler, S, Nemoz, C, Karjalainen-Lindsberg, M-L, Tenhunen, M, Virkkunen, P, Leidenius, M, Smitten, KV, Sipilä, P & Suortti, P 2007, 'High-resolution CT by diffraction-enhanced x-ray imaging: mapping of breast tissue samples and comparison with their histo-pathology', Physics in Medicine and Biology, Vuosikerta 52, Nro 8, Sivut 2197- 2211. https://doi.org/10.1088/0031-9155/52/8/011

High-resolution CT by diffraction-enhanced x-ray imaging : mapping of breast tissue samples and comparison with their histo-pathology. / Bravin, Alberto; Keyriläinen, Jani; Fernandez, Manuel; Fiedler, Stefan; Nemoz, Christian; Karjalainen-Lindsberg, Marja-Liisa; Tenhunen, Mikko; Virkkunen, Pekka; Leidenius, Marjut; Smitten, Karl von; Sipilä, Petri; Suortti, Pekka.

julkaisussa: Physics in Medicine and Biology, Vuosikerta 52, Nro 8, 2007, s. 2197- 2211.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - High-resolution CT by diffraction-enhanced x-ray imaging

T2 - mapping of breast tissue samples and comparison with their histo-pathology

AU - Bravin, Alberto

AU - Keyriläinen, Jani

AU - Fernandez, Manuel

AU - Fiedler, Stefan

AU - Nemoz, Christian

AU - Karjalainen-Lindsberg, Marja-Liisa

AU - Tenhunen, Mikko

AU - Virkkunen, Pekka

AU - Leidenius, Marjut

AU - Smitten, Karl von

AU - Sipilä, Petri

AU - Suortti, Pekka

PY - 2007

Y1 - 2007

N2 - The aim of this study was to introduce high-resolution computed tomography (CT) of breast tumours using the diffraction-enhanced x-ray imaging (DEI) technique and to compare results with radiological and histo-pathological examinations. X-ray CT images of tumour-bearing breast tissue samples were acquired by monochromatic synchrotron radiation (SR). Due to the narrow beam and a large sample-to-detector distance scattering is rejected in the absorption contrast images (SR-CT). Large contrast enhancement is achieved by the use of the DEI-CT method, where the effects of refraction and scatter rejection are analysed by crystal optics. Clinical mammograms and CT images were recorded as reference material for a radiological examination. Three malignant and benign samples were studied in detail. Their radiographs were compared with optical images of stained histological sections. The DEI-CT images map accurately the morphology of the samples, including collagen strands and micro-calcifications of dimensions less than 0.1 mm. Histo-pathological examination and reading of the radiographs were done independently, and the conclusions were in general agreement. High-resolution DEI-CT images show strong contrast and permit visualization of details invisible in clinical radiographs. The radiation dose may be reduced by an order of magnitude without compromising image quality, which would make possible clinical in vivo DEI-CT with future compact SR sources.

AB - The aim of this study was to introduce high-resolution computed tomography (CT) of breast tumours using the diffraction-enhanced x-ray imaging (DEI) technique and to compare results with radiological and histo-pathological examinations. X-ray CT images of tumour-bearing breast tissue samples were acquired by monochromatic synchrotron radiation (SR). Due to the narrow beam and a large sample-to-detector distance scattering is rejected in the absorption contrast images (SR-CT). Large contrast enhancement is achieved by the use of the DEI-CT method, where the effects of refraction and scatter rejection are analysed by crystal optics. Clinical mammograms and CT images were recorded as reference material for a radiological examination. Three malignant and benign samples were studied in detail. Their radiographs were compared with optical images of stained histological sections. The DEI-CT images map accurately the morphology of the samples, including collagen strands and micro-calcifications of dimensions less than 0.1 mm. Histo-pathological examination and reading of the radiographs were done independently, and the conclusions were in general agreement. High-resolution DEI-CT images show strong contrast and permit visualization of details invisible in clinical radiographs. The radiation dose may be reduced by an order of magnitude without compromising image quality, which would make possible clinical in vivo DEI-CT with future compact SR sources.

U2 - 10.1088/0031-9155/52/8/011

DO - 10.1088/0031-9155/52/8/011

M3 - Article

VL - 52

SP - 2197

EP - 2211

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 8

ER -