Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Eva Mittler; Anna Z. Wec; Janne Tynell; Pablo Guardado-Calvo; Julia Wigren-Bystrom; Laura C. Polanco; Cecilia M. O'Brien; Megan M. Slough; Dafna M. Abelson; Alexandra Serris; Mrunal Sakharkar; Gerard Pehau-Arnaudet; Russell R. Bakken; James C. Geoghegan; Rohit K. Jangra; Markus Keller; Larry Zeitlin; Olli Vapalahti; Rainer G. Ulrich; Zachary A. Bornholdt; Clas Ahlm; Felix A. Rey; John M. Dye; Steven B. Bradfute; Tomas Strandin; Andrew S. Herbert; Mattias N. E. Forsell; Laura M. Walker; Kartik Chandran

doi:10.1126/scitranslmed.abl5399

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Eva Mittler, Anna Z. Wec, Janne Tynell, Pablo Guardado-Calvo, Julia Wigren-Bystrom, Laura C. Polanco, Cecilia M. O'Brien, Megan M. Slough, Dafna M. Abelson, Alexandra Serris, Mrunal Sakharkar, Gerard Pehau-Arnaudet, Russell R. Bakken, James C. Geoghegan, Rohit K. Jangra, Markus Keller, Larry Zeitlin, Olli Vapalahti, Rainer G. Ulrich, Zachary A. BornholdtClas Ahlm, Felix A. Rey, John M. Dye, Steven B. Bradfute, Tomas Strandin, Andrew S. Herbert, Mattias N. E. Forsell, Laura M. Walker, Kartik Chandran

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	5399
Lehti	Science translational medicine
Vuosikerta	14
Numero	636
Sivumäärä	16
ISSN	1946-6234
DOI - pysyväislinkit	https://doi.org/10.1126/scitranslmed.abl5399
Tila	Julkaistu - 16 maalisk. 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

3111 Biolääketieteet
11832 Mikrobiologia ja virologia

Pääsy asiakirjaan

10.1126/scitranslmed.abl5399

Siteeraa tätä

Mittler, E., Wec, A. Z., Tynell, J., Guardado-Calvo, P., Wigren-Bystrom, J., Polanco, L. C., O'Brien, C. M., Slough, M. M., Abelson, D. M., Serris, A., Sakharkar, M., Pehau-Arnaudet, G., Bakken, R. R., Geoghegan, J. C., Jangra, R. K., Keller, M., Zeitlin, L., Vapalahti, O., Ulrich, R. G., ... Chandran, K. (2022). Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses. Science translational medicine, 14(636), [5399]. https://doi.org/10.1126/scitranslmed.abl5399

@article{54ddcdb38cf045528aa5673d4ea4898e,

title = "Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses",

keywords = "HUMORAL IMMUNE-RESPONSES, NEUTRALIZING ANTIBODIES, ANDES HANTAVIRUS, MONOCLONAL-ANTIBODIES, INFECTIONS, EPIDEMIOLOGY, SURVIVOR, BURDEN, FUSION, ENTRY, 3111 Biomedicine, 11832 Microbiology and virology",

author = "Eva Mittler and Wec, {Anna Z.} and Janne Tynell and Pablo Guardado-Calvo and Julia Wigren-Bystrom and Polanco, {Laura C.} and O'Brien, {Cecilia M.} and Slough, {Megan M.} and Abelson, {Dafna M.} and Alexandra Serris and Mrunal Sakharkar and Gerard Pehau-Arnaudet and Bakken, {Russell R.} and Geoghegan, {James C.} and Jangra, {Rohit K.} and Markus Keller and Larry Zeitlin and Olli Vapalahti and Ulrich, {Rainer G.} and Bornholdt, {Zachary A.} and Clas Ahlm and Rey, {Felix A.} and Dye, {John M.} and Bradfute, {Steven B.} and Tomas Strandin and Herbert, {Andrew S.} and Forsell, {Mattias N. E.} and Walker, {Laura M.} and Kartik Chandran",

year = "2022",

month = mar,

day = "16",

doi = "10.1126/scitranslmed.abl5399",

language = "English",

volume = "14",

journal = "Science translational medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science (AAAS)",

number = "636",

}

Mittler, E, Wec, AZ, Tynell, J, Guardado-Calvo, P, Wigren-Bystrom, J, Polanco, LC, O'Brien, CM, Slough, MM, Abelson, DM, Serris, A, Sakharkar, M, Pehau-Arnaudet, G, Bakken, RR, Geoghegan, JC, Jangra, RK, Keller, M, Zeitlin, L, Vapalahti, O, Ulrich, RG, Bornholdt, ZA, Ahlm, C, Rey, FA, Dye, JM, Bradfute, SB, Strandin, T, Herbert, AS, Forsell, MNE, Walker, LM & Chandran, K 2022, 'Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses', Science translational medicine, Vuosikerta 14, Nro 636, 5399. https://doi.org/10.1126/scitranslmed.abl5399

TY - JOUR

T1 - Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

AU - Mittler, Eva

AU - Wec, Anna Z.

AU - Tynell, Janne

AU - Guardado-Calvo, Pablo

AU - Wigren-Bystrom, Julia

AU - Polanco, Laura C.

AU - O'Brien, Cecilia M.

AU - Slough, Megan M.

AU - Abelson, Dafna M.

AU - Serris, Alexandra

AU - Sakharkar, Mrunal

AU - Pehau-Arnaudet, Gerard

AU - Bakken, Russell R.

AU - Geoghegan, James C.

AU - Jangra, Rohit K.

AU - Keller, Markus

AU - Zeitlin, Larry

AU - Vapalahti, Olli

AU - Ulrich, Rainer G.

AU - Bornholdt, Zachary A.

AU - Ahlm, Clas

AU - Rey, Felix A.

AU - Dye, John M.

AU - Bradfute, Steven B.

AU - Strandin, Tomas

AU - Herbert, Andrew S.

AU - Forsell, Mattias N. E.

AU - Walker, Laura M.

AU - Chandran, Kartik

PY - 2022/3/16

Y1 - 2022/3/16

KW - HUMORAL IMMUNE-RESPONSES

KW - NEUTRALIZING ANTIBODIES

KW - ANDES HANTAVIRUS

KW - MONOCLONAL-ANTIBODIES

KW - INFECTIONS

KW - EPIDEMIOLOGY

KW - SURVIVOR

KW - BURDEN

KW - FUSION

KW - ENTRY

KW - 3111 Biomedicine

KW - 11832 Microbiology and virology

U2 - 10.1126/scitranslmed.abl5399

DO - 10.1126/scitranslmed.abl5399

M3 - Article

VL - 14

JO - Science translational medicine

JF - Science translational medicine

SN - 1946-6234

IS - 636

M1 - 5399

ER -