Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin

Andras N. Spaan; Anna-Lena Neehus; Emmanuel Laplantine; Frederik Staels; Masato Ogishi; Yoann Seeleuthner; Franck Rapaport; Keenan A. Lacey; Erika Van Nieuwenhove; Maya Chrabieh; David Hum; Melanie Migaud; Araksya Izmiryan; Lazaro Lorenzo; Tatiana Kochetkov; Dani A. C. Heesterbeek; Bart W. Bardoel; Ashley L. DuMont; Kerry Dobbs; Solenne Chardonnet; Soren Heissel; Timour Baslan; Peng Zhang; Rui Yang; Dusan Bogunovic; Herman F. Wunderink; Pieter-Jan A. Haas; Henrik Molina; Griet Van Buggenhout; Stanislas Lyonnet; Luigi D. Notarangelo; Mikko R. J. Seppänen; Robert Weil; Gisela Seminario; Hector Gomez-Tello; Carine Wouters; Mehrnaz Mesdaghi; Mohammad Shahrooei; Xavier Bossuyt; Erdal Sag; Rezan Topaloglu; Seza Ozen; Helen L. Leavis; Maarten M. J. van Eijk; Liliana Bezrodnik; Lizbeth Blancas Galicia; Alain Hovnanian; Aude Nassif; Brigitte Bader-Meunier; Benedicte Neven; Isabelle Meyts; Rik Schrijvers; Anne Puel; Jacinta Bustamante; Ivona Aksentijevich; Daniel L. Kastner; Victor J. Torres; Stephanie Humblet-Baron; Adrian Liston; Laurent Abel; Bertrand Boisson; Jean-Laurent Casanova

doi:10.1126/science.abm6380

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin

Andras N. Spaan, Anna-Lena Neehus, Emmanuel Laplantine, Frederik Staels, Masato Ogishi, Yoann Seeleuthner, Franck Rapaport, Keenan A. Lacey, Erika Van Nieuwenhove, Maya Chrabieh, David Hum, Melanie Migaud, Araksya Izmiryan, Lazaro Lorenzo, Tatiana Kochetkov, Dani A. C. Heesterbeek, Bart W. Bardoel, Ashley L. DuMont, Kerry Dobbs, Solenne ChardonnetSoren Heissel, Timour Baslan, Peng Zhang, Rui Yang, Dusan Bogunovic, Herman F. Wunderink, Pieter-Jan A. Haas, Henrik Molina, Griet Van Buggenhout, Stanislas Lyonnet, Luigi D. Notarangelo, Mikko R. J. Seppänen, Robert Weil, Gisela Seminario, Hector Gomez-Tello, Carine Wouters, Mehrnaz Mesdaghi, Mohammad Shahrooei, Xavier Bossuyt, Erdal Sag, Rezan Topaloglu, Seza Ozen, Helen L. Leavis, Maarten M. J. van Eijk, Liliana Bezrodnik, Lizbeth Blancas Galicia, Alain Hovnanian, Aude Nassif, Brigitte Bader-Meunier, Benedicte Neven, Isabelle Meyts, Rik Schrijvers, Anne Puel, Jacinta Bustamante, Ivona Aksentijevich, Daniel L. Kastner, Victor J. Torres, Stephanie Humblet-Baron, Adrian Liston, Laurent Abel, Bertrand Boisson, Jean-Laurent Casanova

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	6380
Lehti	Science
Vuosikerta	376
Numero	6599
Sivut	1285-+
Sivumäärä	63
ISSN	0036-8075
DOI - pysyväislinkit	https://doi.org/10.1126/science.abm6380
Tila	Julkaistu - 17 kesäk. 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

3111 Biolääketieteet

Pääsy asiakirjaan

10.1126/science.abm6380

science.abm6380.v1Lopullinen julkaistu versio, 3,9 MB

Siteeraa tätä

Spaan, A. N., Neehus, A.-L., Laplantine, E., Staels, F., Ogishi, M., Seeleuthner, Y., Rapaport, F., Lacey, K. A., Van Nieuwenhove, E., Chrabieh, M., Hum, D., Migaud, M., Izmiryan, A., Lorenzo, L., Kochetkov, T., Heesterbeek, D. A. C., Bardoel, B. W., DuMont, A. L., Dobbs, K., ... Casanova, J.-L. (2022). Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin. Science, 376(6599), 1285-+. Artikkeli 6380. https://doi.org/10.1126/science.abm6380

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title = "Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin",

keywords = "PANTON-VALENTINE LEUKOCIDIN, PYOGENIC BACTERIAL-INFECTIONS, DU-CHAT-SYNDROME, HIDRADENITIS SUPPURATIVA, LINEAR UBIQUITIN, INBORN-ERRORS, AUREUS, CRI, HEMOLYSIN, PROTEIN, 3111 Biomedicine",

author = "Spaan, {Andras N.} and Anna-Lena Neehus and Emmanuel Laplantine and Frederik Staels and Masato Ogishi and Yoann Seeleuthner and Franck Rapaport and Lacey, {Keenan A.} and {Van Nieuwenhove}, Erika and Maya Chrabieh and David Hum and Melanie Migaud and Araksya Izmiryan and Lazaro Lorenzo and Tatiana Kochetkov and Heesterbeek, {Dani A. C.} and Bardoel, {Bart W.} and DuMont, {Ashley L.} and Kerry Dobbs and Solenne Chardonnet and Soren Heissel and Timour Baslan and Peng Zhang and Rui Yang and Dusan Bogunovic and Wunderink, {Herman F.} and Haas, {Pieter-Jan A.} and Henrik Molina and {Van Buggenhout}, Griet and Stanislas Lyonnet and Notarangelo, {Luigi D.} and Sepp{\"a}nen, {Mikko R. J.} and Robert Weil and Gisela Seminario and Hector Gomez-Tello and Carine Wouters and Mehrnaz Mesdaghi and Mohammad Shahrooei and Xavier Bossuyt and Erdal Sag and Rezan Topaloglu and Seza Ozen and Leavis, {Helen L.} and {van Eijk}, {Maarten M. J.} and Liliana Bezrodnik and Galicia, {Lizbeth Blancas} and Alain Hovnanian and Aude Nassif and Brigitte Bader-Meunier and Benedicte Neven and Isabelle Meyts and Rik Schrijvers and Anne Puel and Jacinta Bustamante and Ivona Aksentijevich and Kastner, {Daniel L.} and Torres, {Victor J.} and Stephanie Humblet-Baron and Adrian Liston and Laurent Abel and Bertrand Boisson and Jean-Laurent Casanova",

year = "2022",

month = jun,

day = "17",

doi = "10.1126/science.abm6380",

language = "English",

volume = "376",

pages = "1285--+",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science (AAAS)",

number = "6599",

}

Spaan, AN, Neehus, A-L, Laplantine, E, Staels, F, Ogishi, M, Seeleuthner, Y, Rapaport, F, Lacey, KA, Van Nieuwenhove, E, Chrabieh, M, Hum, D, Migaud, M, Izmiryan, A, Lorenzo, L, Kochetkov, T, Heesterbeek, DAC, Bardoel, BW, DuMont, AL, Dobbs, K, Chardonnet, S, Heissel, S, Baslan, T, Zhang, P, Yang, R, Bogunovic, D, Wunderink, HF, Haas, P-JA, Molina, H, Van Buggenhout, G, Lyonnet, S, Notarangelo, LD, Seppänen, MRJ, Weil, R, Seminario, G, Gomez-Tello, H, Wouters, C, Mesdaghi, M, Shahrooei, M, Bossuyt, X, Sag, E, Topaloglu, R, Ozen, S, Leavis, HL, van Eijk, MMJ, Bezrodnik, L, Galicia, LB, Hovnanian, A, Nassif, A, Bader-Meunier, B, Neven, B, Meyts, I, Schrijvers, R, Puel, A, Bustamante, J, Aksentijevich, I, Kastner, DL, Torres, VJ, Humblet-Baron, S, Liston, A, Abel, L, Boisson, B & Casanova, J-L 2022, 'Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin', Science, Vuosikerta 376, Nro 6599, 6380, Sivut 1285-+. https://doi.org/10.1126/science.abm6380

TY - JOUR

T1 - Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin

AU - Spaan, Andras N.

AU - Neehus, Anna-Lena

AU - Laplantine, Emmanuel

AU - Staels, Frederik

AU - Ogishi, Masato

AU - Seeleuthner, Yoann

AU - Rapaport, Franck

AU - Lacey, Keenan A.

AU - Van Nieuwenhove, Erika

AU - Chrabieh, Maya

AU - Hum, David

AU - Migaud, Melanie

AU - Izmiryan, Araksya

AU - Lorenzo, Lazaro

AU - Kochetkov, Tatiana

AU - Heesterbeek, Dani A. C.

AU - Bardoel, Bart W.

AU - DuMont, Ashley L.

AU - Dobbs, Kerry

AU - Chardonnet, Solenne

AU - Heissel, Soren

AU - Baslan, Timour

AU - Zhang, Peng

AU - Yang, Rui

AU - Bogunovic, Dusan

AU - Wunderink, Herman F.

AU - Haas, Pieter-Jan A.

AU - Molina, Henrik

AU - Van Buggenhout, Griet

AU - Lyonnet, Stanislas

AU - Notarangelo, Luigi D.

AU - Seppänen, Mikko R. J.

AU - Weil, Robert

AU - Seminario, Gisela

AU - Gomez-Tello, Hector

AU - Wouters, Carine

AU - Mesdaghi, Mehrnaz

AU - Shahrooei, Mohammad

AU - Bossuyt, Xavier

AU - Sag, Erdal

AU - Topaloglu, Rezan

AU - Ozen, Seza

AU - Leavis, Helen L.

AU - van Eijk, Maarten M. J.

AU - Bezrodnik, Liliana

AU - Galicia, Lizbeth Blancas

AU - Hovnanian, Alain

AU - Nassif, Aude

AU - Bader-Meunier, Brigitte

AU - Neven, Benedicte

AU - Meyts, Isabelle

AU - Schrijvers, Rik

AU - Puel, Anne

AU - Bustamante, Jacinta

AU - Aksentijevich, Ivona

AU - Kastner, Daniel L.

AU - Torres, Victor J.

AU - Humblet-Baron, Stephanie

AU - Liston, Adrian

AU - Abel, Laurent

AU - Boisson, Bertrand

AU - Casanova, Jean-Laurent

PY - 2022/6/17

Y1 - 2022/6/17

KW - PANTON-VALENTINE LEUKOCIDIN

KW - PYOGENIC BACTERIAL-INFECTIONS

KW - DU-CHAT-SYNDROME

KW - HIDRADENITIS SUPPURATIVA

KW - LINEAR UBIQUITIN

KW - INBORN-ERRORS

KW - AUREUS

KW - CRI

KW - HEMOLYSIN

KW - PROTEIN

KW - 3111 Biomedicine

U2 - 10.1126/science.abm6380

DO - 10.1126/science.abm6380

M3 - Article

SN - 0036-8075

VL - 376

SP - 1285-+

JO - Science

JF - Science

IS - 6599

M1 - 6380

ER -