Imaging of lung function using synchrotron radiation computed tomography

what s new?

Sam Bayat, Liisa Porra, Heikki Suhonen, Tibor Janosi, Satu Strengell, Walid Habre, Ferenc Petak, Zoltan Hantos, Pekka Suortti, Anssi Sovijärvi

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    There is a growing interest in imaging techniques as non-invasive means of quantitatively measuring regional lung structure and function. Abnormalities in lung, ventilation due to alterations in airway function such as those observed in asthma and COPD are highly heterogeneous, and experimental methods to study this heterogeneity are crucial for better understanding of disease mechanisms and drug targeting strategies. In severe obstructive diseases requiring mechanical ventilation, the optimal ventilatory strategy to achieve recruitment of poorly ventilated lung zones remains a matter of considerable debate. We have used synchrotron radiation computed tomography (SRCT) for the in vivo Study of regional lung ventilation and airway function. This imaging technique allows direct quantification of stable Xenon (Xe) gas used as an inhaled contrast agent using K-edge subtraction imaging. Dynamics of Xe wash-in can be used to calculate quantitative maps of regional specific lung ventilation. More recently, 9 the development of Spiral-CT has allowed the acquisition of 3D images of the Pulmonary bronchial tree and airspaces. This technique gives access to quantitative measurements of regional lung volume, ventilation, and mechanical properties. Examples of application in an experimental model of allergic asthma and in imaging lung recruitment as a function of mechanical ventilation parameters will be presented. The future orientations of V M this tecnique will be discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
    Alkuperäiskielienglanti
    LehtiEuropean Journal of Radiology
    Vuosikerta68S
    Numero3
    SivutS78-S83
    ISSN0720-048X
    DOI - pysyväislinkit
    TilaJulkaistu - 2008
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Lainaa tätä

    Bayat, Sam ; Porra, Liisa ; Suhonen, Heikki ; Janosi, Tibor ; Strengell, Satu ; Habre, Walid ; Petak, Ferenc ; Hantos, Zoltan ; Suortti, Pekka ; Sovijärvi, Anssi. / Imaging of lung function using synchrotron radiation computed tomography : what s new?. Julkaisussa: European Journal of Radiology. 2008 ; Vuosikerta 68S, Nro 3. Sivut S78-S83.
    @article{5b293426b75e482f91c335a82ce0d215,
    title = "Imaging of lung function using synchrotron radiation computed tomography: what s new?",
    abstract = "There is a growing interest in imaging techniques as non-invasive means of quantitatively measuring regional lung structure and function. Abnormalities in lung, ventilation due to alterations in airway function such as those observed in asthma and COPD are highly heterogeneous, and experimental methods to study this heterogeneity are crucial for better understanding of disease mechanisms and drug targeting strategies. In severe obstructive diseases requiring mechanical ventilation, the optimal ventilatory strategy to achieve recruitment of poorly ventilated lung zones remains a matter of considerable debate. We have used synchrotron radiation computed tomography (SRCT) for the in vivo Study of regional lung ventilation and airway function. This imaging technique allows direct quantification of stable Xenon (Xe) gas used as an inhaled contrast agent using K-edge subtraction imaging. Dynamics of Xe wash-in can be used to calculate quantitative maps of regional specific lung ventilation. More recently, 9 the development of Spiral-CT has allowed the acquisition of 3D images of the Pulmonary bronchial tree and airspaces. This technique gives access to quantitative measurements of regional lung volume, ventilation, and mechanical properties. Examples of application in an experimental model of allergic asthma and in imaging lung recruitment as a function of mechanical ventilation parameters will be presented. The future orientations of V M this tecnique will be discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.",
    author = "Sam Bayat and Liisa Porra and Heikki Suhonen and Tibor Janosi and Satu Strengell and Walid Habre and Ferenc Petak and Zoltan Hantos and Pekka Suortti and Anssi Sovij{\"a}rvi",
    year = "2008",
    doi = "10.1016/j.ejrad.2008.04.043",
    language = "English",
    volume = "68S",
    pages = "S78--S83",
    journal = "European Journal of Radiology",
    issn = "0720-048X",
    publisher = "ELSEVIER IRELAND LTD",
    number = "3",

    }

    Bayat, S, Porra, L, Suhonen, H, Janosi, T, Strengell, S, Habre, W, Petak, F, Hantos, Z, Suortti, P & Sovijärvi, A 2008, 'Imaging of lung function using synchrotron radiation computed tomography: what s new?', European Journal of Radiology, Vuosikerta 68S, Nro 3, Sivut S78-S83. https://doi.org/10.1016/j.ejrad.2008.04.043

    Imaging of lung function using synchrotron radiation computed tomography : what s new? / Bayat, Sam; Porra, Liisa; Suhonen, Heikki; Janosi, Tibor; Strengell, Satu; Habre, Walid; Petak, Ferenc; Hantos, Zoltan; Suortti, Pekka; Sovijärvi, Anssi.

    julkaisussa: European Journal of Radiology, Vuosikerta 68S, Nro 3, 2008, s. S78-S83.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - Imaging of lung function using synchrotron radiation computed tomography

    T2 - what s new?

    AU - Bayat, Sam

    AU - Porra, Liisa

    AU - Suhonen, Heikki

    AU - Janosi, Tibor

    AU - Strengell, Satu

    AU - Habre, Walid

    AU - Petak, Ferenc

    AU - Hantos, Zoltan

    AU - Suortti, Pekka

    AU - Sovijärvi, Anssi

    PY - 2008

    Y1 - 2008

    N2 - There is a growing interest in imaging techniques as non-invasive means of quantitatively measuring regional lung structure and function. Abnormalities in lung, ventilation due to alterations in airway function such as those observed in asthma and COPD are highly heterogeneous, and experimental methods to study this heterogeneity are crucial for better understanding of disease mechanisms and drug targeting strategies. In severe obstructive diseases requiring mechanical ventilation, the optimal ventilatory strategy to achieve recruitment of poorly ventilated lung zones remains a matter of considerable debate. We have used synchrotron radiation computed tomography (SRCT) for the in vivo Study of regional lung ventilation and airway function. This imaging technique allows direct quantification of stable Xenon (Xe) gas used as an inhaled contrast agent using K-edge subtraction imaging. Dynamics of Xe wash-in can be used to calculate quantitative maps of regional specific lung ventilation. More recently, 9 the development of Spiral-CT has allowed the acquisition of 3D images of the Pulmonary bronchial tree and airspaces. This technique gives access to quantitative measurements of regional lung volume, ventilation, and mechanical properties. Examples of application in an experimental model of allergic asthma and in imaging lung recruitment as a function of mechanical ventilation parameters will be presented. The future orientations of V M this tecnique will be discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    AB - There is a growing interest in imaging techniques as non-invasive means of quantitatively measuring regional lung structure and function. Abnormalities in lung, ventilation due to alterations in airway function such as those observed in asthma and COPD are highly heterogeneous, and experimental methods to study this heterogeneity are crucial for better understanding of disease mechanisms and drug targeting strategies. In severe obstructive diseases requiring mechanical ventilation, the optimal ventilatory strategy to achieve recruitment of poorly ventilated lung zones remains a matter of considerable debate. We have used synchrotron radiation computed tomography (SRCT) for the in vivo Study of regional lung ventilation and airway function. This imaging technique allows direct quantification of stable Xenon (Xe) gas used as an inhaled contrast agent using K-edge subtraction imaging. Dynamics of Xe wash-in can be used to calculate quantitative maps of regional specific lung ventilation. More recently, 9 the development of Spiral-CT has allowed the acquisition of 3D images of the Pulmonary bronchial tree and airspaces. This technique gives access to quantitative measurements of regional lung volume, ventilation, and mechanical properties. Examples of application in an experimental model of allergic asthma and in imaging lung recruitment as a function of mechanical ventilation parameters will be presented. The future orientations of V M this tecnique will be discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    U2 - 10.1016/j.ejrad.2008.04.043

    DO - 10.1016/j.ejrad.2008.04.043

    M3 - Article

    VL - 68S

    SP - S78-S83

    JO - European Journal of Radiology

    JF - European Journal of Radiology

    SN - 0720-048X

    IS - 3

    ER -