Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease

FinnGen Study; Jake Lin; Nina Mars; Yu Fu; Pietari Ripatti; Tuomo Kiiskinen; Taru Tukiainen; Samuli Ripatti; Matti Pirinen

doi:10.1016/j.jacbts.2023.07.006

Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease

FinnGen Study, Jake Lin, Nina Mars, Yu Fu, Pietari Ripatti, Tuomo Kiiskinen, Taru Tukiainen, Samuli Ripatti, Matti Pirinen

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Abstrakti

There are several established biomarkers for coronary heart disease (CHD), including blood pressure, cholesterol, and lipoproteins. It is of high interest to determine how a combined polygenic risk score (PRS) of CHD-associated biomarkers (BioPRS) can further improve genetic prediction of CHD. We developed CHDBioPRS, combining BioPRS with PRS of CHD in the UK Biobank and tested it on FinnGen. We found that BioPRS was clearly predictive of CHD and that CHDBioPRS improved the standard CHD PRS. The largest effect was observed with early onset cases in FinnGen, with HRs above 2 per standard deviation of CHDBioPRS.

Alkuperäiskieli	englanti
Lehti	JACC: Basic to Translational Science
Vuosikerta	8
Numero	12
Sivut	1489-1499
Sivumäärä	11
ISSN	2452-302X
DOI - pysyväislinkit	https://doi.org/10.1016/j.jacbts.2023.07.006
Tila	Julkaistu - jouluk. 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lisätietoja

Publisher Copyright:
© 2023 The Authors

Tieteenalat

3121 Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet

Pääsy asiakirjaan

10.1016/j.jacbts.2023.07.006

1-s2.0-S2452302X23002875-mainLopullinen julkaistu versio, 982 KBLisenssi: CC BY

Siteeraa tätä

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abstract = "There are several established biomarkers for coronary heart disease (CHD), including blood pressure, cholesterol, and lipoproteins. It is of high interest to determine how a combined polygenic risk score (PRS) of CHD-associated biomarkers (BioPRS) can further improve genetic prediction of CHD. We developed CHDBioPRS, combining BioPRS with PRS of CHD in the UK Biobank and tested it on FinnGen. We found that BioPRS was clearly predictive of CHD and that CHDBioPRS improved the standard CHD PRS. The largest effect was observed with early onset cases in FinnGen, with HRs above 2 per standard deviation of CHDBioPRS.",

keywords = "biomarkers, coronary heart disease, genomics, GWAS, polygenic risk scores, 3121 General medicine, internal medicine and other clinical medicine",

author = "{FinnGen Study} and Jake Lin and Nina Mars and Yu Fu and Pietari Ripatti and Tuomo Kiiskinen and Taru Tukiainen and Samuli Ripatti and Matti Pirinen",

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doi = "10.1016/j.jacbts.2023.07.006",

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TY - JOUR

T1 - Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease

AU - FinnGen Study

AU - Lin, Jake

AU - Mars, Nina

AU - Fu, Yu

AU - Ripatti, Pietari

AU - Kiiskinen, Tuomo

AU - Tukiainen, Taru

AU - Ripatti, Samuli

AU - Pirinen, Matti

PY - 2023/12

Y1 - 2023/12

N2 - There are several established biomarkers for coronary heart disease (CHD), including blood pressure, cholesterol, and lipoproteins. It is of high interest to determine how a combined polygenic risk score (PRS) of CHD-associated biomarkers (BioPRS) can further improve genetic prediction of CHD. We developed CHDBioPRS, combining BioPRS with PRS of CHD in the UK Biobank and tested it on FinnGen. We found that BioPRS was clearly predictive of CHD and that CHDBioPRS improved the standard CHD PRS. The largest effect was observed with early onset cases in FinnGen, with HRs above 2 per standard deviation of CHDBioPRS.

AB - There are several established biomarkers for coronary heart disease (CHD), including blood pressure, cholesterol, and lipoproteins. It is of high interest to determine how a combined polygenic risk score (PRS) of CHD-associated biomarkers (BioPRS) can further improve genetic prediction of CHD. We developed CHDBioPRS, combining BioPRS with PRS of CHD in the UK Biobank and tested it on FinnGen. We found that BioPRS was clearly predictive of CHD and that CHDBioPRS improved the standard CHD PRS. The largest effect was observed with early onset cases in FinnGen, with HRs above 2 per standard deviation of CHDBioPRS.

KW - biomarkers

KW - coronary heart disease

KW - genomics

KW - GWAS

KW - polygenic risk scores

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.1016/j.jacbts.2023.07.006

DO - 10.1016/j.jacbts.2023.07.006

M3 - Article

AN - SCOPUS:85174732276

SN - 2452-302X

VL - 8

SP - 1489

EP - 1499

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

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ER -