Abstrakti
Purpose: To report the unforeseen complication of total obstruction of a glaucoma drainage implant (GDI) tube lumen by white deposit material and to present a preliminary report identifying the composition of this material. Methods: Two subjects with a high IOP due to total obstruction of a GDI tube were reviewed. Both patients had a long history with brinzolamide and timolol maleate eye drops. The GDI tube was swept with a 5-0 polypropylene suture stent in order to open the tube. The intraluminal solid sample was successfully collected from the implant tube in one patient. High-performance liquid chromatography-mass spectrometry (HPLC-MS) was used to determine the origin of the intraluminal sample. Results: Intraluminal deposits containing components of antiglaucoma drugs e.g., timolol and brinzolamide are a rare cause of total obstruction of GDI tubes. Conclusions: Our study describes a new cause of total obstruction GDI tubes. The long-term use of timolol maleate and brinzolamide and their presence in the intraluminal solid sample collected from the blocked GDI tube suggest that the glaucoma medication may have a role in the pathogenesis. However, the exact mechanism is unknown and requires further studies.
Alkuperäiskieli | englanti |
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Lehti | European Journal of Ophthalmology |
Vuosikerta | 33 |
Numero | 1 |
Sivut | 307-311 |
Sivumäärä | 5 |
ISSN | 1120-6721 |
DOI - pysyväislinkit | |
Tila | Julkaistu - tammik. 2023 |
OKM-julkaisutyyppi | A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu |
Lisätietoja
Funding Information:The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Elsemay Björn Fund, Päijät-Häme Joint Authority for Health and Wellbeing,
Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Elsemay Björn Fund, Päijät-Häme Joint Authority for Health and Wellbeing,
Publisher Copyright:
© The Author(s) 2022.
Tieteenalat
- 3125 Korva-, nenä- ja kurkkutaudit, silmätaudit