Alkuperäiskieli | englanti |
---|---|
Lehti | Journal of the American Chemical Society |
Vuosikerta | 141 |
Numero | 21 |
Sivut | 8450-8461 |
Sivumäärä | 12 |
ISSN | 0002-7863 |
DOI - pysyväislinkit | |
Tila | Julkaistu - 29 toukok. 2019 |
OKM-julkaisutyyppi | A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu |
Lisätietoja
Publisher Copyright:© 2019 American Chemical Society.
Tieteenalat
- 1182 Biokemia, solu- ja molekyylibiologia
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julkaisussa: Journal of the American Chemical Society, Vuosikerta 141, Nro 21, 29.05.2019, s. 8450-8461.
Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu
TY - JOUR
T1 - Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
AU - Zong, Guanghui
AU - Hu, Zhijian
AU - O'Keefe, Sarah
AU - Tranter, Dale
AU - Iannotti, Michael J.
AU - Baron, Ludivine
AU - Hall, Belinda
AU - Corfield, Katherine
AU - Paatero, Anja O.
AU - Henderson, Mark J.
AU - Roboti, Peristera
AU - Zhou, Jianhong
AU - Sun, Xianwei
AU - Govindarajan, Mugunthan
AU - Rohde, Jason M.
AU - Blanchard, Nicolas
AU - Simmonds, Rachel
AU - Inglese, James
AU - Du, Yuchun
AU - Demangel, Caroline
AU - High, Stephen
AU - Paavilainen, Ville O.
AU - Shi, Wei Q.
N1 - Funding Information: We thank the Arkansas Nano & Bio Materials Characterization Facility at the Institute for Nano Sciences & Engineering for our imaging studies, and Prof Yoshito Kishi (Harvard University) for the kind gift of synthetic mycolactone A/B used by S.H. and R.S. W.S. is supported by Grant No. R15GM116032 from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) and startup funds from the University of Arkansas. This work was also supported in part by Grant No. P30 GM103450 from the National Institute of General Medical Sciences of the NIH and by seed money from the Arkansas Biosciences Institute (ABI). S.O’K. is the recipient of a Biotechnology and Biological Sciences Research Council (BBSRC) Doctoral Training Programme Award (BB/J014478/ 1), and S.H. holds a Welcome Trust Investigator Award in Science (204957/Z/16/Z). The alpha-1 antitrypsin work was supported by the Alpha-1 Foundation (J.I. and M.J.I.). J.I. and M.J.H. were supported by the intramural program of NCATS, National Institutes of Health, projects 1ZIATR000048-03 (J.I.) and ZIATR000063-04 (M.J.H.). R.S. holds a Welcome Trust Investigator Award in Science (202843/Z/16/Z). C.D. received funding from the Institut Pasteur, the Institut National de la Santé et de la Recherche Med́ icale, and the Fondation Raoul Follereau. N.B.’s synthesis and chemical biology studies of mycolactone were supported by CNRS, Université de Strasbourg, Fondations Potier et Follereau, and the Investisse-ment d’Avenir (Idex Unistra). V.O.P. is supported by the Academy of Finland (Grants 289737 and 314672) and the Sigrid Juselius Foundation. Funding Information: We thank the Arkansas Nano & Bio Materials Characterization Facility at the Institute for Nano Sciences & Engineering for our imaging studies, and Prof Yoshito Kishi (Harvard University) for the kind gift of synthetic mycolactone A/B used by S.H. and R.S. W.S. is supported by Grant No. R15GM116032 from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) and startup funds from the University of Arkansas. This work was also supported in part by Grant No. P30 GM103450 from the National Institute of General Medical Sciences of the NIH and by seed money from the Arkansas Biosciences Institute (ABI). S.O'K. is the recipient of a Biotechnology and Biological Sciences Research Council (BBSRC) Doctoral Training Programme Award (BB/J014478/1), and S.H. holds a Welcome Trust Investigator Award in Science (204957/Z/16/Z). The alpha-1 antitrypsin work was supported by the Alpha-1 Foundation (J.I. and M.J.I.). J.I. and M.J.H. were supported by the intramural program of NCATS, National Institutes of Health, projects 1ZIATR000048-03 (J.I.) and ZIATR000063-04 (M.J.H.). R.S. holds a Welcome Trust Investigator Award in Science (202843/Z/16/Z). C.D. received funding from the Institut Pasteur, the Institut National de la Sante et de la Recherche Medicale, and the Fondation Raoul Follereau. N.B.'s synthesis and chemical biology studies of mycolactone were supported by CNRS, Universite de Strasbourg, Fondations Potier et Follereau and the Investissement d'Avenir (Idex Unistra). V.O.P. is supported by the Academy of Finland (Grants 289737 and 314672) and the Sigrid Juselius Foundation. Publisher Copyright: © 2019 American Chemical Society.
PY - 2019/5/29
Y1 - 2019/5/29
KW - NATURAL-PRODUCTS
KW - BIOLOGICAL EVALUATION
KW - RESIN GLYCOSIDES
KW - MYCOLACTONE
KW - INSIGHTS
KW - APRATOXIN
KW - BLOCKADE
KW - SQUAMOSA
KW - REVEALS
KW - ANALOGS
KW - 1182 Biochemistry, cell and molecular biology
UR - http://www.scopus.com/inward/record.url?scp=85066120803&partnerID=8YFLogxK
U2 - 10.1021/jacs.8b13506
DO - 10.1021/jacs.8b13506
M3 - Article
C2 - 31059257
SN - 0002-7863
VL - 141
SP - 8450
EP - 8461
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 21
ER -