Ki-67, p53, ER receptors, ploidy and S phase as long-term prognostic factors in T1 node-negative breast cancer

Mikael Railo, Johan Lundin, Caj Haglund, Karl von Smitten, Stig Nordling

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    "Background: The aim of the present study was to evaluate a series of biomarkers with regard to long-term prognostic value in patients with T1 (<= 2 cm) node-negative breast cancer. Method: The prognostic value of Ki-67, p53, oestrogen receptor (ER) immunohistochemical labelling, flow-cytometric S phase fraction and ploidy was evaluated in 212 patients with pT1N0M0 breast cancer. The median follow-up time was 15.9 years (range 0.2-27.2 years). Results: In an analysis of breast cancer-specific survival up to 5 years, high Ki-67 (>= 10%; p = 0.002), high p53 (>= 20%; p = 0.01), negative ER (< 30%; p = 0.01) as well as aneuploidy of the tumour (p = 0.02) were significant prognostic factors. When the follow-up was extended to 10 years, only Ki-67 (p = 0.03) was significantly associated with outcome and beyond 15 years none of the studied markers provided significant prognostic information when analyzed separately. There was a weak but significant difference in long-term survival when patients with a combination of high Ki- 67 (>= 10%), high SPF (> 3%) and high p53 (>= 20%) were compared to patients with other combinations (p = 0.03). Conclusion: According to the results of our series, it seems that several prognostic markers which are associated with short-term survival (<= 5 years) in pT1N0M0 breast cancer may not be significant predictors of long-term (> 15 years) breast cancer-specific survival. Copyright (c) 2007 S. Karger AG, Basel"
    Alkuperäiskielienglanti
    LehtiTumor Biology
    Vuosikerta28
    Numero1
    Sivut45-51
    Sivumäärä7
    ISSN1010-4283
    DOI - pysyväislinkit
    TilaJulkaistu - 2007
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Lainaa tätä

    Railo, Mikael ; Lundin, Johan ; Haglund, Caj ; Smitten, Karl von ; Nordling, Stig. / Ki-67, p53, ER receptors, ploidy and S phase as long-term prognostic factors in T1 node-negative breast cancer. Julkaisussa: Tumor Biology. 2007 ; Vuosikerta 28, Nro 1. Sivut 45-51.
    @article{687e5df6c8214bb1bc4906a3315fe559,
    title = "Ki-67, p53, ER receptors, ploidy and S phase as long-term prognostic factors in T1 node-negative breast cancer",
    abstract = "{"}Background: The aim of the present study was to evaluate a series of biomarkers with regard to long-term prognostic value in patients with T1 (<= 2 cm) node-negative breast cancer. Method: The prognostic value of Ki-67, p53, oestrogen receptor (ER) immunohistochemical labelling, flow-cytometric S phase fraction and ploidy was evaluated in 212 patients with pT1N0M0 breast cancer. The median follow-up time was 15.9 years (range 0.2-27.2 years). Results: In an analysis of breast cancer-specific survival up to 5 years, high Ki-67 (>= 10{\%}; p = 0.002), high p53 (>= 20{\%}; p = 0.01), negative ER (< 30{\%}; p = 0.01) as well as aneuploidy of the tumour (p = 0.02) were significant prognostic factors. When the follow-up was extended to 10 years, only Ki-67 (p = 0.03) was significantly associated with outcome and beyond 15 years none of the studied markers provided significant prognostic information when analyzed separately. There was a weak but significant difference in long-term survival when patients with a combination of high Ki- 67 (>= 10{\%}), high SPF (> 3{\%}) and high p53 (>= 20{\%}) were compared to patients with other combinations (p = 0.03). Conclusion: According to the results of our series, it seems that several prognostic markers which are associated with short-term survival (<= 5 years) in pT1N0M0 breast cancer may not be significant predictors of long-term (> 15 years) breast cancer-specific survival. Copyright (c) 2007 S. Karger AG, Basel{"}",
    author = "Mikael Railo and Johan Lundin and Caj Haglund and Smitten, {Karl von} and Stig Nordling",
    year = "2007",
    doi = "10.1159/000097702",
    language = "English",
    volume = "28",
    pages = "45--51",
    journal = "Tumor Biology",
    issn = "1010-4283",
    publisher = "SAGE Publications Ltd STM",
    number = "1",

    }

    Ki-67, p53, ER receptors, ploidy and S phase as long-term prognostic factors in T1 node-negative breast cancer. / Railo, Mikael; Lundin, Johan; Haglund, Caj; Smitten, Karl von; Nordling, Stig.

    julkaisussa: Tumor Biology, Vuosikerta 28, Nro 1, 2007, s. 45-51.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - Ki-67, p53, ER receptors, ploidy and S phase as long-term prognostic factors in T1 node-negative breast cancer

    AU - Railo, Mikael

    AU - Lundin, Johan

    AU - Haglund, Caj

    AU - Smitten, Karl von

    AU - Nordling, Stig

    PY - 2007

    Y1 - 2007

    N2 - "Background: The aim of the present study was to evaluate a series of biomarkers with regard to long-term prognostic value in patients with T1 (<= 2 cm) node-negative breast cancer. Method: The prognostic value of Ki-67, p53, oestrogen receptor (ER) immunohistochemical labelling, flow-cytometric S phase fraction and ploidy was evaluated in 212 patients with pT1N0M0 breast cancer. The median follow-up time was 15.9 years (range 0.2-27.2 years). Results: In an analysis of breast cancer-specific survival up to 5 years, high Ki-67 (>= 10%; p = 0.002), high p53 (>= 20%; p = 0.01), negative ER (< 30%; p = 0.01) as well as aneuploidy of the tumour (p = 0.02) were significant prognostic factors. When the follow-up was extended to 10 years, only Ki-67 (p = 0.03) was significantly associated with outcome and beyond 15 years none of the studied markers provided significant prognostic information when analyzed separately. There was a weak but significant difference in long-term survival when patients with a combination of high Ki- 67 (>= 10%), high SPF (> 3%) and high p53 (>= 20%) were compared to patients with other combinations (p = 0.03). Conclusion: According to the results of our series, it seems that several prognostic markers which are associated with short-term survival (<= 5 years) in pT1N0M0 breast cancer may not be significant predictors of long-term (> 15 years) breast cancer-specific survival. Copyright (c) 2007 S. Karger AG, Basel"

    AB - "Background: The aim of the present study was to evaluate a series of biomarkers with regard to long-term prognostic value in patients with T1 (<= 2 cm) node-negative breast cancer. Method: The prognostic value of Ki-67, p53, oestrogen receptor (ER) immunohistochemical labelling, flow-cytometric S phase fraction and ploidy was evaluated in 212 patients with pT1N0M0 breast cancer. The median follow-up time was 15.9 years (range 0.2-27.2 years). Results: In an analysis of breast cancer-specific survival up to 5 years, high Ki-67 (>= 10%; p = 0.002), high p53 (>= 20%; p = 0.01), negative ER (< 30%; p = 0.01) as well as aneuploidy of the tumour (p = 0.02) were significant prognostic factors. When the follow-up was extended to 10 years, only Ki-67 (p = 0.03) was significantly associated with outcome and beyond 15 years none of the studied markers provided significant prognostic information when analyzed separately. There was a weak but significant difference in long-term survival when patients with a combination of high Ki- 67 (>= 10%), high SPF (> 3%) and high p53 (>= 20%) were compared to patients with other combinations (p = 0.03). Conclusion: According to the results of our series, it seems that several prognostic markers which are associated with short-term survival (<= 5 years) in pT1N0M0 breast cancer may not be significant predictors of long-term (> 15 years) breast cancer-specific survival. Copyright (c) 2007 S. Karger AG, Basel"

    U2 - 10.1159/000097702

    DO - 10.1159/000097702

    M3 - Article

    VL - 28

    SP - 45

    EP - 51

    JO - Tumor Biology

    JF - Tumor Biology

    SN - 1010-4283

    IS - 1

    ER -