Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites

Tutkimustuotos: ArtikkelijulkaisuKatsausartikkelivertaisarvioitu

Abstrakti

Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a fundamental process underlying hypercholesterolemia, a high blood cholesterol concentration, affecting more than 40% of the western population. Membrane contact sites influence endosomal dynamics, plasma membrane lipid composition, and cellular cholesterol distribution. However, if we focus on LDL-related trafficking events we mostly discuss them in an isolated fashion, without cellular context. It is our goal to change this perspective and to highlight that all steps from LDL internalization to receptor recycling are likely associated with dynamic membrane contact sites in which endosomes engage with the endoplasmic reticulum and other organelles.

Alkuperäiskielienglanti
Artikkeli826379
LehtiFrontiers in Cell and Developmental Biology
Vuosikerta10
Sivumäärä6
ISSN2296-634X
DOI - pysyväislinkit
TilaJulkaistu - 24 tammik. 2022
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

Tieteenalat

  • 3111 Biolääketieteet
  • 1182 Biokemia, solu- ja molekyylibiologia

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