Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine

Ujunwa Cynthia Okoye-Okafor, Komal K. Javarappa, Dimitrios Tsallos, Joseph Saad, Daozheng Yang, Chi Zhang, Lumie Benard, Victor J. Thiruthuvanathan, Sally Cole, Stephen Ruiz, Madhuri Tatiparthy, Gaurav Choudhary, Stefanie Defronzo, Boris A. Bartholdy, Celine Pallaud, Pedro Marques Ramos, Aditi Shastri, Amit Verma, Caroline A. Heckman, Britta Will

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Alkuperäiskielienglanti
Artikkelie20212228
LehtiJournal of Experimental Medicine
Vuosikerta219
Numero11
Sivumäärä24
ISSN0022-1007
DOI - pysyväislinkit
TilaJulkaistu - 7 marrask. 2022
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lisätietoja

Funding Information:
We thank Dr. D. Sun from the Einstein Stem Cell Isolation and Xenotransplantation Facility (funded through New York Stem Cell Science grant C029154) and C. Prophete for assistance with flow cytometry and D. Reynolds and W. Tran from the Einstein Genomics Core Facility for help with the microarray experiments. We thank Dr. J. Chen for helpful suggestions. We also thank P. Schultes from the Department of Cell Biology at Albert Einstein College of Medicine for expert technical assistance. We would also like to thank Drs. J. Bussel and K. Gritsman, as well as the team members of the Will and Heckman groups for very helpful discussions and suggestions.

Funding Information:
This work was supported by Novartis Pharmaceuticals, the National Institutes of Health grants K12CA132783 (to U.C. Okoye-Okafor), CA230756, and DK105134 (to B. Will), and Cancer Center Support Grant P30CA013330 (pilot project to B. Will).

Funding Information:
We thank Dr. D. Sun from the Einstein Stem Cell Isolation and Xenotransplantation Facility (funded through New York Stem Cell Science grant C029154) and C. Prophete for assistance with flow cytometry and D. Reynolds and W. Tran from the Einstein Genomics Core Facility for help with the microarray experiments. We thank Dr. J. Chen for helpful suggestions. We also thank P. Schultes from the Department of Cell Biology at Albert Einstein College of Medicine for expert technical assistance. We would also like to thank Drs. J. Bussel and K. Gritsman, as well as the team members of the Will and Heckman groups for very helpful discussions and suggestions. This work was supported by Novartis Pharmaceuticals, the National Institutes of Health grants K12CA132783 (to U.C. Okoye-Okafor), CA230756, and DK105134 (to B. Will), and Cancer Center Support Grant P30CA013330 (pilot project to B. Will).

Publisher Copyright:
© 2022 Okoye-Okafor et al.

Tieteenalat

  • 3111 Biolääketieteet
  • 1182 Biokemia, solu- ja molekyylibiologia

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