Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

Richard S Houlston, Iina Niittymäki, Sari Tuupanen, Auli Karhu, Lauri A Aaltonen, CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    "Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC."
    Alkuperäiskielienglanti
    LehtiNature Genetics
    Vuosikerta40
    Numero12
    Sivut1426-1435
    Sivumäärä10
    ISSN1061-4036
    DOI - pysyväislinkit
    TilaJulkaistu - 2008
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Tieteenalat

    • 311 Peruslääketieteet

    Lainaa tätä

    Houlston, R. S., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A., & CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium (2008). Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nature Genetics, 40(12), 1426-1435. https://doi.org/10.1038/ng.262
    Houlston, Richard S ; Niittymäki, Iina ; Tuupanen, Sari ; Karhu, Auli ; Aaltonen, Lauri A ; CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium. / Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Julkaisussa: Nature Genetics. 2008 ; Vuosikerta 40, Nro 12. Sivut 1426-1435.
    @article{75fb13f2ccfb457881264ec296c3ad45,
    title = "Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer",
    abstract = "{"}Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.{"}",
    keywords = "311 Basic medicine",
    author = "Houlston, {Richard S} and Iina Niittym{\"a}ki and Sari Tuupanen and Auli Karhu and Aaltonen, {Lauri A} and {CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium}",
    year = "2008",
    doi = "10.1038/ng.262",
    language = "English",
    volume = "40",
    pages = "1426--1435",
    journal = "Nature Genetics",
    issn = "1061-4036",
    publisher = "Nature Publishing Group",
    number = "12",

    }

    Houlston, RS, Niittymäki, I, Tuupanen, S, Karhu, A, Aaltonen, LA & CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium 2008, 'Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer', Nature Genetics, Vuosikerta 40, Nro 12, Sivut 1426-1435. https://doi.org/10.1038/ng.262

    Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. / Houlston, Richard S; Niittymäki, Iina; Tuupanen, Sari ; Karhu, Auli; Aaltonen, Lauri A; CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium.

    julkaisussa: Nature Genetics, Vuosikerta 40, Nro 12, 2008, s. 1426-1435.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

    AU - Houlston, Richard S

    AU - Niittymäki, Iina

    AU - Tuupanen, Sari

    AU - Karhu, Auli

    AU - Aaltonen, Lauri A

    AU - CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium

    PY - 2008

    Y1 - 2008

    N2 - "Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC."

    AB - "Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC."

    KW - 311 Basic medicine

    U2 - 10.1038/ng.262

    DO - 10.1038/ng.262

    M3 - Article

    VL - 40

    SP - 1426

    EP - 1435

    JO - Nature Genetics

    JF - Nature Genetics

    SN - 1061-4036

    IS - 12

    ER -

    Houlston RS, Niittymäki I, Tuupanen S, Karhu A, Aaltonen LA, CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nature Genetics. 2008;40(12):1426-1435. https://doi.org/10.1038/ng.262