Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models

Kimberly A. Jett; Zakery N. Baker; Amzad Hossain; Aren Boulet; Paul A. Cobine; Sagnika Ghosh; Philip Ng; Orhan Yilmaz; Kris Barreto; John DeCoteau; Karen Mochoruk; George N. Ioannou; Christopher Savard; Sai Yuan; Osama H. M. H. Abdalla; Christopher Lowden; Byung-Eun Kim; Hai-Ying Mary Cheng; Brendan J. Battersby; Vishal M. Gohil; Scot C. Leary

doi:10.1172/JCI154684

Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models

Kimberly A. Jett, Zakery N. Baker, Amzad Hossain, Aren Boulet, Paul A. Cobine, Sagnika Ghosh, Philip Ng, Orhan Yilmaz, Kris Barreto, John DeCoteau, Karen Mochoruk, George N. Ioannou, Christopher Savard, Sai Yuan, Osama H. M. H. Abdalla, Christopher Lowden, Byung-Eun Kim, Hai-Ying Mary Cheng, Brendan J. Battersby, Vishal M. GohilScot C. Leary

Biotekniikan instituutti

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Alkuperäiskieli	englanti
Artikkeli	e154684
Lehti	Journal of Clinical Investigation
Vuosikerta	133
Numero	1
Sivumäärä	14
ISSN	0021-9738
DOI - pysyväislinkit	https://doi.org/10.1172/JCI154684
Tila	Julkaistu - 3 tammik. 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

1182 Biokemia, solu- ja molekyylibiologia

Pääsy asiakirjaan

10.1172/JCI154684Lisenssi: CC BY

154684.2-20221129140202-covered-e0fd13ba177f913fd3156f593ead4cfdLopullinen julkaistu versio, 3,24 MBLisenssi: CC BY

Siteeraa tätä

Jett, K. A., Baker, Z. N., Hossain, A., Boulet, A., Cobine, P. A., Ghosh, S., Ng, P., Yilmaz, O., Barreto, K., DeCoteau, J., Mochoruk, K., Ioannou, G. N., Savard, C., Yuan, S., Abdalla, O. H. M. H., Lowden, C., Kim, B.-E., Cheng, H.-Y. M., Battersby, B. J., ... Leary, S. C. (2023). Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models. Journal of Clinical Investigation, 133(1), Artikkeli e154684. https://doi.org/10.1172/JCI154684

@article{cc22f26f55ba475298f69532b20698f7,

title = "Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models",

keywords = "Receptor-binding fragment, Alpha-fetoprotein, Organelle stress, Gene, Liver, Sco1, Transduction, Maintenance, Biomarker, 1182 Biochemistry, cell and molecular biology",

author = "Jett, {Kimberly A.} and Baker, {Zakery N.} and Amzad Hossain and Aren Boulet and Cobine, {Paul A.} and Sagnika Ghosh and Philip Ng and Orhan Yilmaz and Kris Barreto and John DeCoteau and Karen Mochoruk and Ioannou, {George N.} and Christopher Savard and Sai Yuan and Abdalla, {Osama H. M. H.} and Christopher Lowden and Byung-Eun Kim and Cheng, {Hai-Ying Mary} and Battersby, {Brendan J.} and Gohil, {Vishal M.} and Leary, {Scot C.}",

year = "2023",

month = jan,

day = "3",

doi = "10.1172/JCI154684",

language = "English",

volume = "133",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "AMERICAN SOCIETY FOR CLINICAL INVESTIGATION",

number = "1",

}

Jett, KA, Baker, ZN, Hossain, A, Boulet, A, Cobine, PA, Ghosh, S, Ng, P, Yilmaz, O, Barreto, K, DeCoteau, J, Mochoruk, K, Ioannou, GN, Savard, C, Yuan, S, Abdalla, OHMH, Lowden, C, Kim, B-E, Cheng, H-YM, Battersby, BJ, Gohil, VM & Leary, SC 2023, 'Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models', Journal of Clinical Investigation, Vuosikerta 133, Nro 1, e154684. https://doi.org/10.1172/JCI154684

Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models. / Jett, Kimberly A.; Baker, Zakery N.; Hossain, Amzad et al.
julkaisussa: Journal of Clinical Investigation, Vuosikerta 133, Nro 1, e154684, 03.01.2023.

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

TY - JOUR

T1 - Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models

AU - Jett, Kimberly A.

AU - Baker, Zakery N.

AU - Hossain, Amzad

AU - Boulet, Aren

AU - Cobine, Paul A.

AU - Ghosh, Sagnika

AU - Ng, Philip

AU - Yilmaz, Orhan

AU - Barreto, Kris

AU - DeCoteau, John

AU - Mochoruk, Karen

AU - Ioannou, George N.

AU - Savard, Christopher

AU - Yuan, Sai

AU - Abdalla, Osama H. M. H.

AU - Lowden, Christopher

AU - Kim, Byung-Eun

AU - Cheng, Hai-Ying Mary

AU - Battersby, Brendan J.

AU - Gohil, Vishal M.

AU - Leary, Scot C.

PY - 2023/1/3

Y1 - 2023/1/3

KW - Receptor-binding fragment

KW - Alpha-fetoprotein

KW - Organelle stress

KW - Gene

KW - Liver

KW - Sco1

KW - Transduction

KW - Maintenance

KW - Biomarker

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1172/JCI154684

DO - 10.1172/JCI154684

M3 - Article

C2 - 36301669

SN - 0021-9738

VL - 133

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 1

M1 - e154684

ER -