Mortality associated with occupational exposure in Helsinki, Finland - a 24-year follow-up

Juuso Jalasto; Ritva Luukkonen; Ari Lindqvist; Arnulf Langhammer; Hannu Kankaanranta; Helena Backman; Eva Rönmark; Anssi Sovijärvi; Paula Kauppi; Päivi Piirilä

doi:10.1097/JOM.0000000000002718

Mortality associated with occupational exposure in Helsinki, Finland - a 24-year follow-up

Juuso Jalasto, Ritva Luukkonen, Ari Lindqvist, Arnulf Langhammer, Hannu Kankaanranta, Helena Backman, Eva Rönmark, Anssi Sovijärvi, Paula Kauppi, Päivi Piirilä

Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu

Abstrakti

Objectives: Our objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.

Methods: We divided the participants based on the answers to asthma and COPD diagnoses and occupational exposure and used a combined effects model and compared the results to no asthma or COPD with no occupational exposure.

Results: High exposure had a hazard ratio (HR) 1.34 (1.11-1.62) and asthma and COPD coexistence 1.58 (1.10-2.27). The combined effects of intermediate exposure and coexistence had a HR 2.20 (1.18-4.09), high exposure with co-existence 1.94 (1.10-3.42) for overall mortality and sub-hazard ratio for respiratory related mortality sHR 3.21 (1.87-5.50).

Conclusions: High occupational exposure increased overall, but not respiratory related mortality hazard while co-existing asthma and COPD overall and respiratory related hazard of mortality

Alkuperäiskieli	englanti
Lehti	Journal of Occupational and Environmental Medicine
Vuosikerta	65
Numero	1
Sivut	22-28
Sivumäärä	7
ISSN	1076-2752
DOI - pysyväislinkit	https://doi.org/10.1097/JOM.0000000000002718
Tila	Julkaistu - 1 tammik. 2023
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

3121 Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet
Asthma
COPD
Occupational Exposure
Mortality

Pääsy asiakirjaan

10.1097/JOM.0000000000002718Lisenssi: CC BY

Mortality_Associated_With_Occupational_Exposure_in.4Lopullinen julkaistu versio, 298 KBLisenssi: CC BY-NC-ND

Siteeraa tätä

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abstract = "Objectives: Our objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.Methods: We divided the participants based on the answers to asthma and COPD diagnoses and occupational exposure and used a combined effects model and compared the results to no asthma or COPD with no occupational exposure.Results: High exposure had a hazard ratio (HR) 1.34 (1.11-1.62) and asthma and COPD coexistence 1.58 (1.10-2.27). The combined effects of intermediate exposure and coexistence had a HR 2.20 (1.18-4.09), high exposure with co-existence 1.94 (1.10-3.42) for overall mortality and sub-hazard ratio for respiratory related mortality sHR 3.21 (1.87-5.50).Conclusions: High occupational exposure increased overall, but not respiratory related mortality hazard while co-existing asthma and COPD overall and respiratory related hazard of mortality",

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AU - Jalasto, Juuso

AU - Luukkonen, Ritva

AU - Lindqvist, Ari

AU - Langhammer, Arnulf

AU - Kankaanranta, Hannu

AU - Backman, Helena

AU - Rönmark, Eva

AU - Sovijärvi, Anssi

AU - Kauppi, Paula

AU - Piirilä, Päivi

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N2 - Objectives: Our objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.Methods: We divided the participants based on the answers to asthma and COPD diagnoses and occupational exposure and used a combined effects model and compared the results to no asthma or COPD with no occupational exposure.Results: High exposure had a hazard ratio (HR) 1.34 (1.11-1.62) and asthma and COPD coexistence 1.58 (1.10-2.27). The combined effects of intermediate exposure and coexistence had a HR 2.20 (1.18-4.09), high exposure with co-existence 1.94 (1.10-3.42) for overall mortality and sub-hazard ratio for respiratory related mortality sHR 3.21 (1.87-5.50).Conclusions: High occupational exposure increased overall, but not respiratory related mortality hazard while co-existing asthma and COPD overall and respiratory related hazard of mortality

AB - Objectives: Our objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.Methods: We divided the participants based on the answers to asthma and COPD diagnoses and occupational exposure and used a combined effects model and compared the results to no asthma or COPD with no occupational exposure.Results: High exposure had a hazard ratio (HR) 1.34 (1.11-1.62) and asthma and COPD coexistence 1.58 (1.10-2.27). The combined effects of intermediate exposure and coexistence had a HR 2.20 (1.18-4.09), high exposure with co-existence 1.94 (1.10-3.42) for overall mortality and sub-hazard ratio for respiratory related mortality sHR 3.21 (1.87-5.50).Conclusions: High occupational exposure increased overall, but not respiratory related mortality hazard while co-existing asthma and COPD overall and respiratory related hazard of mortality

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