Music therapy enhances executive functions and prefrontal structural neuroplasticity after traumatic brain injury

Sini-Tuuli Siponkoski, Noelia Martinez Molina, Linda Kuusela, Sari Laitinen, Milla Holma, Mirja Ahlfors, Päivi Jordan-Kilkki, Katja Ala-Kauhaluoma, Susanna Melkas, Mari Johanna Pekkola, Antoni Rodriguez-Fornells, Matti Laine, Aarne Ylinen, Pekka Rantanen, Sanna Kaarina Koskinen, Teppo Tapio Särkämö

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Traumatic brain injury (TBI) causes lifelong cognitive deficits, particularly impairments of executive functioning (EF) and attention, and is also associated with progressive brain matter volume loss. Musical training and music-based rehabilitation have been shown to enhance cognitive functioning and neuroplasticity, but the potential rehabilitative effects of music in TBI are still largely unknown. The aim of the present cross-over randomized controlled trial (RCT) was to determine the clinical efficacy of music therapy on cognitive functioning in TBI and to explore its neural basis. Using an AB/BA design, 40 patients with moderate or severe TBI were randomized to receive a 3-month neurological music therapy intervention either during the first (AB, n = 20) or second (BA, n = 20) half of a 6-month follow-up period. Neuropsychological and motor testing and MRI scanning was performed at baseline and at the 3-month and 6-month stage. Results showed that general EF (as indicated by the Frontal Assessment Battery) improved more in the AB group than in the BA group over the 3-month and 6-month periods. Both groups also showed an improvement in set shifting and vigilance performance during the intervention period compared to the control period. Voxel-based morphometry (VBM) analysis of the structural MRI data indicated that grey matter volume (GMV) in the right inferior frontal gyrus increased significantly in both groups during the intervention vs. control period, which also correlated with cognitive improvement in set shifting. These findings suggest that neurological music therapy enhances EF and attention and induces fine-grained neuroanatomical changes in prefrontal areas.
Alkuperäiskielienglanti
LehtiJournal of Neurotrauma
ISSN0897-7151
TilaJätetty - 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 515 Psykologia
  • 6131 Teatteri, tanssi, musiikki, muut esittävät taiteet
  • 3124 Neurologia ja psykiatria
  • 3112 Neurotieteet

Lainaa tätä

Siponkoski, Sini-Tuuli ; Martinez Molina, Noelia ; Kuusela, Linda ; Laitinen, Sari ; Holma, Milla ; Ahlfors, Mirja ; Jordan-Kilkki, Päivi ; Ala-Kauhaluoma, Katja ; Melkas, Susanna ; Pekkola, Mari Johanna ; Rodriguez-Fornells, Antoni ; Laine, Matti ; Ylinen, Aarne ; Rantanen, Pekka ; Koskinen, Sanna Kaarina ; Särkämö, Teppo Tapio. / Music therapy enhances executive functions and prefrontal structural neuroplasticity after traumatic brain injury. Julkaisussa: Journal of Neurotrauma. 2019.
@article{f22062411637421fbeed48c56fa3e6dc,
title = "Music therapy enhances executive functions and prefrontal structural neuroplasticity after traumatic brain injury",
abstract = "Traumatic brain injury (TBI) causes lifelong cognitive deficits, particularly impairments of executive functioning (EF) and attention, and is also associated with progressive brain matter volume loss. Musical training and music-based rehabilitation have been shown to enhance cognitive functioning and neuroplasticity, but the potential rehabilitative effects of music in TBI are still largely unknown. The aim of the present cross-over randomized controlled trial (RCT) was to determine the clinical efficacy of music therapy on cognitive functioning in TBI and to explore its neural basis. Using an AB/BA design, 40 patients with moderate or severe TBI were randomized to receive a 3-month neurological music therapy intervention either during the first (AB, n = 20) or second (BA, n = 20) half of a 6-month follow-up period. Neuropsychological and motor testing and MRI scanning was performed at baseline and at the 3-month and 6-month stage. Results showed that general EF (as indicated by the Frontal Assessment Battery) improved more in the AB group than in the BA group over the 3-month and 6-month periods. Both groups also showed an improvement in set shifting and vigilance performance during the intervention period compared to the control period. Voxel-based morphometry (VBM) analysis of the structural MRI data indicated that grey matter volume (GMV) in the right inferior frontal gyrus increased significantly in both groups during the intervention vs. control period, which also correlated with cognitive improvement in set shifting. These findings suggest that neurological music therapy enhances EF and attention and induces fine-grained neuroanatomical changes in prefrontal areas.",
keywords = "515 Psychology, 6131 Theatre, dance, music, other performing arts, 3124 Neurology and psychiatry, 3112 Neurosciences",
author = "Sini-Tuuli Siponkoski and {Martinez Molina}, Noelia and Linda Kuusela and Sari Laitinen and Milla Holma and Mirja Ahlfors and P{\"a}ivi Jordan-Kilkki and Katja Ala-Kauhaluoma and Susanna Melkas and Pekkola, {Mari Johanna} and Antoni Rodriguez-Fornells and Matti Laine and Aarne Ylinen and Pekka Rantanen and Koskinen, {Sanna Kaarina} and S{\"a}rk{\"a}m{\"o}, {Teppo Tapio}",
year = "2019",
language = "English",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert",

}

Siponkoski, S-T, Martinez Molina, N, Kuusela, L, Laitinen, S, Holma, M, Ahlfors, M, Jordan-Kilkki, P, Ala-Kauhaluoma, K, Melkas, S, Pekkola, MJ, Rodriguez-Fornells, A, Laine, M, Ylinen, A, Rantanen, P, Koskinen, SK & Särkämö, TT 2019, 'Music therapy enhances executive functions and prefrontal structural neuroplasticity after traumatic brain injury', Journal of Neurotrauma.

Music therapy enhances executive functions and prefrontal structural neuroplasticity after traumatic brain injury. / Siponkoski, Sini-Tuuli; Martinez Molina, Noelia; Kuusela, Linda; Laitinen, Sari; Holma, Milla; Ahlfors, Mirja; Jordan-Kilkki, Päivi; Ala-Kauhaluoma, Katja; Melkas, Susanna; Pekkola, Mari Johanna; Rodriguez-Fornells, Antoni; Laine, Matti; Ylinen, Aarne; Rantanen, Pekka; Koskinen, Sanna Kaarina; Särkämö, Teppo Tapio.

julkaisussa: Journal of Neurotrauma, 2019.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Music therapy enhances executive functions and prefrontal structural neuroplasticity after traumatic brain injury

AU - Siponkoski, Sini-Tuuli

AU - Martinez Molina, Noelia

AU - Kuusela, Linda

AU - Laitinen, Sari

AU - Holma, Milla

AU - Ahlfors, Mirja

AU - Jordan-Kilkki, Päivi

AU - Ala-Kauhaluoma, Katja

AU - Melkas, Susanna

AU - Pekkola, Mari Johanna

AU - Rodriguez-Fornells, Antoni

AU - Laine, Matti

AU - Ylinen, Aarne

AU - Rantanen, Pekka

AU - Koskinen, Sanna Kaarina

AU - Särkämö, Teppo Tapio

PY - 2019

Y1 - 2019

N2 - Traumatic brain injury (TBI) causes lifelong cognitive deficits, particularly impairments of executive functioning (EF) and attention, and is also associated with progressive brain matter volume loss. Musical training and music-based rehabilitation have been shown to enhance cognitive functioning and neuroplasticity, but the potential rehabilitative effects of music in TBI are still largely unknown. The aim of the present cross-over randomized controlled trial (RCT) was to determine the clinical efficacy of music therapy on cognitive functioning in TBI and to explore its neural basis. Using an AB/BA design, 40 patients with moderate or severe TBI were randomized to receive a 3-month neurological music therapy intervention either during the first (AB, n = 20) or second (BA, n = 20) half of a 6-month follow-up period. Neuropsychological and motor testing and MRI scanning was performed at baseline and at the 3-month and 6-month stage. Results showed that general EF (as indicated by the Frontal Assessment Battery) improved more in the AB group than in the BA group over the 3-month and 6-month periods. Both groups also showed an improvement in set shifting and vigilance performance during the intervention period compared to the control period. Voxel-based morphometry (VBM) analysis of the structural MRI data indicated that grey matter volume (GMV) in the right inferior frontal gyrus increased significantly in both groups during the intervention vs. control period, which also correlated with cognitive improvement in set shifting. These findings suggest that neurological music therapy enhances EF and attention and induces fine-grained neuroanatomical changes in prefrontal areas.

AB - Traumatic brain injury (TBI) causes lifelong cognitive deficits, particularly impairments of executive functioning (EF) and attention, and is also associated with progressive brain matter volume loss. Musical training and music-based rehabilitation have been shown to enhance cognitive functioning and neuroplasticity, but the potential rehabilitative effects of music in TBI are still largely unknown. The aim of the present cross-over randomized controlled trial (RCT) was to determine the clinical efficacy of music therapy on cognitive functioning in TBI and to explore its neural basis. Using an AB/BA design, 40 patients with moderate or severe TBI were randomized to receive a 3-month neurological music therapy intervention either during the first (AB, n = 20) or second (BA, n = 20) half of a 6-month follow-up period. Neuropsychological and motor testing and MRI scanning was performed at baseline and at the 3-month and 6-month stage. Results showed that general EF (as indicated by the Frontal Assessment Battery) improved more in the AB group than in the BA group over the 3-month and 6-month periods. Both groups also showed an improvement in set shifting and vigilance performance during the intervention period compared to the control period. Voxel-based morphometry (VBM) analysis of the structural MRI data indicated that grey matter volume (GMV) in the right inferior frontal gyrus increased significantly in both groups during the intervention vs. control period, which also correlated with cognitive improvement in set shifting. These findings suggest that neurological music therapy enhances EF and attention and induces fine-grained neuroanatomical changes in prefrontal areas.

KW - 515 Psychology

KW - 6131 Theatre, dance, music, other performing arts

KW - 3124 Neurology and psychiatry

KW - 3112 Neurosciences

M3 - Article

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

ER -