Neurofibrillary tau pathology modulated by genetic variation of [alpha]-synuclein

Terhi Peuralinna, Minna Oinas, Tuomo Polvikoski, Anders Paetau, Raimo Sulkava, Leena Niinistö, Hannu Kalimo, Dena Hernandez, John Hardy, Andrew Singleton, Pentti J Tienari, Liisa Myllykangas

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

"We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical P-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration."
Alkuperäiskielienglanti
LehtiAnnals of Neurology
Vuosikerta64
Numero3
Sivut348-352
Sivumäärä5
ISSN0364-5134
DOI - pysyväislinkit
TilaJulkaistu - 2008
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lainaa tätä

Peuralinna, Terhi ; Oinas, Minna ; Polvikoski, Tuomo ; Paetau, Anders ; Sulkava, Raimo ; Niinistö, Leena ; Kalimo, Hannu ; Hernandez, Dena ; Hardy, John ; Singleton, Andrew ; Tienari, Pentti J ; Myllykangas, Liisa. / Neurofibrillary tau pathology modulated by genetic variation of [alpha]-synuclein. Julkaisussa: Annals of Neurology. 2008 ; Vuosikerta 64, Nro 3. Sivut 348-352.
@article{18e619b34af548269d8a00180c0101cf,
title = "Neurofibrillary tau pathology modulated by genetic variation of [alpha]-synuclein",
abstract = "{"}We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical P-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration.{"}",
author = "Terhi Peuralinna and Minna Oinas and Tuomo Polvikoski and Anders Paetau and Raimo Sulkava and Leena Niinist{\"o} and Hannu Kalimo and Dena Hernandez and John Hardy and Andrew Singleton and Tienari, {Pentti J} and Liisa Myllykangas",
year = "2008",
doi = "10.1002/ana.21446",
language = "English",
volume = "64",
pages = "348--352",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "Wiley",
number = "3",

}

Neurofibrillary tau pathology modulated by genetic variation of [alpha]-synuclein. / Peuralinna, Terhi; Oinas, Minna; Polvikoski, Tuomo; Paetau, Anders; Sulkava, Raimo; Niinistö, Leena; Kalimo, Hannu; Hernandez, Dena; Hardy, John; Singleton, Andrew; Tienari, Pentti J; Myllykangas, Liisa.

julkaisussa: Annals of Neurology, Vuosikerta 64, Nro 3, 2008, s. 348-352.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Neurofibrillary tau pathology modulated by genetic variation of [alpha]-synuclein

AU - Peuralinna, Terhi

AU - Oinas, Minna

AU - Polvikoski, Tuomo

AU - Paetau, Anders

AU - Sulkava, Raimo

AU - Niinistö, Leena

AU - Kalimo, Hannu

AU - Hernandez, Dena

AU - Hardy, John

AU - Singleton, Andrew

AU - Tienari, Pentti J

AU - Myllykangas, Liisa

PY - 2008

Y1 - 2008

N2 - "We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical P-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration."

AB - "We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical P-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration."

U2 - 10.1002/ana.21446

DO - 10.1002/ana.21446

M3 - Article

VL - 64

SP - 348

EP - 352

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 3

ER -