Neuron-specific enolase in retinoblastoma. An immunohistochemical study

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Abstrakti

Forty-six retinoblastoma specimens were studied for the presence of neuron-specific enolase (NSE) in the tumour cells and in the remaining morphologically normal retina. The laboratory method was a sensitive immunohistochemical peroxidase staining procedure, and normal ocular nerves were used as positive controls. Neuron-specific enolase was found in perikarya and cell processes in all layers of morphologically normal appearing neuroretina, but not in Müller's cells. All but two of the retinoblastomata studied contained positively staining tumour cells, whereas stromal cells remained constantly negative. Many Flexner-Wintersteiner rosettes stained positively as well. The proportion of retinoblastoma cells expressing neuron-specific enolase seemed to be greater in small tumours, in bilateral cases, and in tumours that contained rosettes. The presence of neuron-specific enolase in tumour cells seems to favour a neuronal or neuroectodermal origin for retinoblastoma, but it should be noted that this marker has recently been found in several non-neuronal and non-neuroectodermal malignant neoplasms.
Alkuperäiskielienglanti
LehtiActa ophthalmologica
Vuosikerta64
Numero1
Sivut19-25
Sivumäärä7
ISSN0001-639X
DOI - pysyväislinkit
TilaJulkaistu - 1986
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 3125 Korva-, nenä- ja kurkkutaudit, silmätaudit
  • OPHTHALMOLOGY
  • OPHTHALMIC PATHOLOGY
  • OPHTHALMIC ONCOLOGY

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