Neuronal regulation of immune responses in the central nervous system

Li Tian, Heikki Rauvala, Carl G Gahmberg

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    Kuvaus

    The central nervous system (CNS) has traditionally been considered to be immunologically privileged, but over the years there has been a re-evaluation of this dogma. To date, studies have tended to focus on the immune functions of glial cells, whereas the roles of neurons have been regarded as passive and their immune-regulatory properties have been less examined. However, recent findings indicate that CNS neurons actively participate in immune regulation by controlling their glial cell counterparts and infiltrated T cells. Here, we describe the immune-regulatory roles of CNS neurons by both contact-dependent and contact-independent mechanisms. In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity.
    Alkuperäiskielienglanti
    LehtiTrends in Immunology
    Vuosikerta30
    Numero2
    Sivut91-99
    Sivumäärä9
    ISSN1471-4906
    DOI - pysyväislinkit
    TilaJulkaistu - 2009
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

    Tieteenalat

    • 118 Biotieteet

    Lainaa tätä

    Tian, Li ; Rauvala, Heikki ; Gahmberg, Carl G. / Neuronal regulation of immune responses in the central nervous system. Julkaisussa: Trends in Immunology. 2009 ; Vuosikerta 30, Nro 2. Sivut 91-99.
    @article{08a9af97d261466e872122aa86f3f387,
    title = "Neuronal regulation of immune responses in the central nervous system",
    abstract = "The central nervous system (CNS) has traditionally been considered to be immunologically privileged, but over the years there has been a re-evaluation of this dogma. To date, studies have tended to focus on the immune functions of glial cells, whereas the roles of neurons have been regarded as passive and their immune-regulatory properties have been less examined. However, recent findings indicate that CNS neurons actively participate in immune regulation by controlling their glial cell counterparts and infiltrated T cells. Here, we describe the immune-regulatory roles of CNS neurons by both contact-dependent and contact-independent mechanisms. In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity.",
    keywords = "CELL-ADHESION MOLECULES, NECROSIS-FACTOR-ALPHA, NEURODEGENERATIVE DISEASES, T-CELLS, MULTIPLE-SCLEROSIS, MICROGLIAL ACTIVATION, LEUKOCYTE INTEGRIN, APOPTOTIC NEURONS, CNS INFLAMMATION, DENDRITIC CELLS, 118 Biological sciences",
    author = "Li Tian and Heikki Rauvala and Gahmberg, {Carl G}",
    year = "2009",
    doi = "10.1016/j.it.2008.11.002",
    language = "English",
    volume = "30",
    pages = "91--99",
    journal = "Trends in Immunology",
    issn = "1471-4906",
    publisher = "Elsevier Ltd.",
    number = "2",

    }

    Neuronal regulation of immune responses in the central nervous system. / Tian, Li; Rauvala, Heikki; Gahmberg, Carl G.

    julkaisussa: Trends in Immunology, Vuosikerta 30, Nro 2, 2009, s. 91-99.

    Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

    TY - JOUR

    T1 - Neuronal regulation of immune responses in the central nervous system

    AU - Tian, Li

    AU - Rauvala, Heikki

    AU - Gahmberg, Carl G

    PY - 2009

    Y1 - 2009

    N2 - The central nervous system (CNS) has traditionally been considered to be immunologically privileged, but over the years there has been a re-evaluation of this dogma. To date, studies have tended to focus on the immune functions of glial cells, whereas the roles of neurons have been regarded as passive and their immune-regulatory properties have been less examined. However, recent findings indicate that CNS neurons actively participate in immune regulation by controlling their glial cell counterparts and infiltrated T cells. Here, we describe the immune-regulatory roles of CNS neurons by both contact-dependent and contact-independent mechanisms. In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity.

    AB - The central nervous system (CNS) has traditionally been considered to be immunologically privileged, but over the years there has been a re-evaluation of this dogma. To date, studies have tended to focus on the immune functions of glial cells, whereas the roles of neurons have been regarded as passive and their immune-regulatory properties have been less examined. However, recent findings indicate that CNS neurons actively participate in immune regulation by controlling their glial cell counterparts and infiltrated T cells. Here, we describe the immune-regulatory roles of CNS neurons by both contact-dependent and contact-independent mechanisms. In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity.

    KW - CELL-ADHESION MOLECULES

    KW - NECROSIS-FACTOR-ALPHA

    KW - NEURODEGENERATIVE DISEASES

    KW - T-CELLS

    KW - MULTIPLE-SCLEROSIS

    KW - MICROGLIAL ACTIVATION

    KW - LEUKOCYTE INTEGRIN

    KW - APOPTOTIC NEURONS

    KW - CNS INFLAMMATION

    KW - DENDRITIC CELLS

    KW - 118 Biological sciences

    U2 - 10.1016/j.it.2008.11.002

    DO - 10.1016/j.it.2008.11.002

    M3 - Article

    VL - 30

    SP - 91

    EP - 99

    JO - Trends in Immunology

    JF - Trends in Immunology

    SN - 1471-4906

    IS - 2

    ER -