Oral glucose tolerance test results in early pregnancy: A Finnish population-based cohort study

Mervi Jokelainen, Beata Stach‑Lempinen, Kristiina Rönö, Hannu Kautiainen, Arja Nenonen , Kari Teramo, Miira M. Klemetti

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Abstrakti

Aims: To analyze early-pregnancy oral glucose tolerance test (OGTT) results and differences between early- and late-pregnancy OGTT results in a population-based cohort.

Methods: From 3/2013 to 12/2016, pregnant women in South Karelia, Finland, were invited to undergo a 2-hour 75 g OGTT at 12-16 weeks' gestation (OGTT1) and, if normal, repeat testing at 24-28 weeks (OGTT2). Early and late gestational diabetes (GDM) were diagnosed using the same nationally endorsed criteria (fasting [FPG], 1- or 2-hour plasma glucose >= 5.3, >10.0 or >8.6 mmol/L, respectively).

Results: In OGTT1 (n = 1401), the mean (SD) FPG, 1- and 2-hour values were 4.85 (0.34), 6.63 (1.73) and 5.60 (1.28) mmol/L, respectively. Early GDM was diagnosed in 209 (14.9%). In OGTT2 (n = 1067), late GDM was diagnosed in 114 (10.6%). In women without GDM (n = 953), the mean FPG values were higher and post-load values lower in OGTT1 vs. OGTT2. No interaction effects of gestational timepoint and maternal BMI on OGTT results were detected, except for the 2-hour value. In women with late GDM, both mean FPG and post-load values were lower in OGTT1 vs. OGTT2. Results were similar employing the IADPSG GDM criteria.

Conclusions: Our findings suggest that gestational-age specific OGTT thresholds for early GDM diagnosis need to be generated. (C) 2020 Elsevier B.V. All rights reserved.

Alkuperäiskielienglanti
Artikkeli108077
LehtiDiabetes Research and Clinical Practice
Vuosikerta162
Sivumäärä8
ISSN0168-8227
DOI - pysyväislinkit
TilaJulkaistu - huhtikuuta 2020
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Lisätietoja

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Tieteenalat

  • 3121 Sisätaudit
  • Gestational diabetes
  • Obesity
  • Oral glucose tolerance test
  • Fasting plasma glucose
  • Post-load values
  • 3123 Naisten- ja lastentaudit
  • Early pregnancy

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