Outer-inner Dual Reinforced Micro/Nano Hierarchical Scaffolds for Promoting Osteogenesis

Jincheng Tang, Yong Gu, Hongbo Zhang, Liang Wu, Yun Xu, Jiannan Mao, Tianwen Xin, Tingjun Ye, Lianfu Deng, Wenguo Cui, Hélder A. Santos, Liang Chen

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

Kuvaus

Biomimetic scaffolds have been extensively studied for guiding osteogenesis through structural cues. Inspired by the natural bone growth process, we have employed a hierarchical outer-inner dual reinforcing strategy, which relies on the interfacial ionic bond interaction between amine/calcium and carboxyl group, to build a nanofiber/particle dual strengthened hierarchical silk fibroin scaffold. The scaffold can provide applicable form of osteogenic structural cue and mimic the natural bone forming process. Owing to the active interaction between compositions located in the outer pore space and the inner pore wall, the scaffold has over 4 times improvement on mechanical property, followed by significant alteration on cell-scaffold interaction pattern, demonstrated by over 2 times’ elevation on the spreading area and enhanced osteogenic activity potentially involving activities of integrin, Vinculin and Yes-associated protein (YAP). In vivo performance of the scaffold identified the inherent osteogenic effect of structural cue, which promotes rapid and uniform regeneration. Overall, the hierarchical scaffold is promising in promoting uniform bone regeneration through its specific structural cue endowed by its micro-nano construction.
Alkuperäiskielienglanti
LehtiNanoscale
Vuosikerta11
Numero34
Sivut15794-15803
Sivumäärä10
ISSN2040-3364
DOI - pysyväislinkit
TilaJulkaistu - 14 syyskuuta 2019
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä, vertaisarvioitu

Tieteenalat

  • 116 Kemia
  • 221 Nanoteknologia
  • 317 Farmasia

Lainaa tätä

Tang, J., Gu, Y., Zhang, H., Wu, L., Xu, Y., Mao, J., ... Chen, L. (2019). Outer-inner Dual Reinforced Micro/Nano Hierarchical Scaffolds for Promoting Osteogenesis. Nanoscale, 11(34), 15794-15803. https://doi.org/10.1039/C9NR03264A
Tang, Jincheng ; Gu, Yong ; Zhang, Hongbo ; Wu, Liang ; Xu, Yun ; Mao, Jiannan ; Xin, Tianwen ; Ye, Tingjun ; Deng, Lianfu ; Cui, Wenguo ; Santos, Hélder A. ; Chen, Liang. / Outer-inner Dual Reinforced Micro/Nano Hierarchical Scaffolds for Promoting Osteogenesis. Julkaisussa: Nanoscale. 2019 ; Vuosikerta 11, Nro 34. Sivut 15794-15803.
@article{646516043a0c4bb39fa17e5279cd01dd,
title = "Outer-inner Dual Reinforced Micro/Nano Hierarchical Scaffolds for Promoting Osteogenesis",
abstract = "Biomimetic scaffolds have been extensively studied for guiding osteogenesis through structural cues. Inspired by the natural bone growth process, we have employed a hierarchical outer-inner dual reinforcing strategy, which relies on the interfacial ionic bond interaction between amine/calcium and carboxyl group, to build a nanofiber/particle dual strengthened hierarchical silk fibroin scaffold. The scaffold can provide applicable form of osteogenic structural cue and mimic the natural bone forming process. Owing to the active interaction between compositions located in the outer pore space and the inner pore wall, the scaffold has over 4 times improvement on mechanical property, followed by significant alteration on cell-scaffold interaction pattern, demonstrated by over 2 times’ elevation on the spreading area and enhanced osteogenic activity potentially involving activities of integrin, Vinculin and Yes-associated protein (YAP). In vivo performance of the scaffold identified the inherent osteogenic effect of structural cue, which promotes rapid and uniform regeneration. Overall, the hierarchical scaffold is promising in promoting uniform bone regeneration through its specific structural cue endowed by its micro-nano construction.",
keywords = "ADHESION, ARCHITECTURE, BONE REGENERATION, DIFFERENTIATION, GROWTH, I COLLAGEN, MESENCHYMAL STEM-CELLS, OSSIFICATION, PROTEINS, SURFACES, 116 Chemical sciences, 221 Nano-technology, 317 Pharmacy",
author = "Jincheng Tang and Yong Gu and Hongbo Zhang and Liang Wu and Yun Xu and Jiannan Mao and Tianwen Xin and Tingjun Ye and Lianfu Deng and Wenguo Cui and Santos, {H{\'e}lder A.} and Liang Chen",
year = "2019",
month = "9",
day = "14",
doi = "10.1039/C9NR03264A",
language = "English",
volume = "11",
pages = "15794--15803",
journal = "Nanoscale",
issn = "2040-3364",
publisher = "The Royal Society of Chemistry",
number = "34",

}

Tang, J, Gu, Y, Zhang, H, Wu, L, Xu, Y, Mao, J, Xin, T, Ye, T, Deng, L, Cui, W, Santos, HA & Chen, L 2019, 'Outer-inner Dual Reinforced Micro/Nano Hierarchical Scaffolds for Promoting Osteogenesis', Nanoscale, Vuosikerta 11, Nro 34, Sivut 15794-15803. https://doi.org/10.1039/C9NR03264A

Outer-inner Dual Reinforced Micro/Nano Hierarchical Scaffolds for Promoting Osteogenesis. / Tang, Jincheng; Gu, Yong; Zhang, Hongbo; Wu, Liang; Xu, Yun; Mao, Jiannan; Xin, Tianwen; Ye, Tingjun; Deng, Lianfu; Cui, Wenguo; Santos, Hélder A.; Chen, Liang.

julkaisussa: Nanoscale, Vuosikerta 11, Nro 34, 14.09.2019, s. 15794-15803.

Tutkimustuotos: ArtikkelijulkaisuArtikkeliTieteellinenvertaisarvioitu

TY - JOUR

T1 - Outer-inner Dual Reinforced Micro/Nano Hierarchical Scaffolds for Promoting Osteogenesis

AU - Tang, Jincheng

AU - Gu, Yong

AU - Zhang, Hongbo

AU - Wu, Liang

AU - Xu, Yun

AU - Mao, Jiannan

AU - Xin, Tianwen

AU - Ye, Tingjun

AU - Deng, Lianfu

AU - Cui, Wenguo

AU - Santos, Hélder A.

AU - Chen, Liang

PY - 2019/9/14

Y1 - 2019/9/14

N2 - Biomimetic scaffolds have been extensively studied for guiding osteogenesis through structural cues. Inspired by the natural bone growth process, we have employed a hierarchical outer-inner dual reinforcing strategy, which relies on the interfacial ionic bond interaction between amine/calcium and carboxyl group, to build a nanofiber/particle dual strengthened hierarchical silk fibroin scaffold. The scaffold can provide applicable form of osteogenic structural cue and mimic the natural bone forming process. Owing to the active interaction between compositions located in the outer pore space and the inner pore wall, the scaffold has over 4 times improvement on mechanical property, followed by significant alteration on cell-scaffold interaction pattern, demonstrated by over 2 times’ elevation on the spreading area and enhanced osteogenic activity potentially involving activities of integrin, Vinculin and Yes-associated protein (YAP). In vivo performance of the scaffold identified the inherent osteogenic effect of structural cue, which promotes rapid and uniform regeneration. Overall, the hierarchical scaffold is promising in promoting uniform bone regeneration through its specific structural cue endowed by its micro-nano construction.

AB - Biomimetic scaffolds have been extensively studied for guiding osteogenesis through structural cues. Inspired by the natural bone growth process, we have employed a hierarchical outer-inner dual reinforcing strategy, which relies on the interfacial ionic bond interaction between amine/calcium and carboxyl group, to build a nanofiber/particle dual strengthened hierarchical silk fibroin scaffold. The scaffold can provide applicable form of osteogenic structural cue and mimic the natural bone forming process. Owing to the active interaction between compositions located in the outer pore space and the inner pore wall, the scaffold has over 4 times improvement on mechanical property, followed by significant alteration on cell-scaffold interaction pattern, demonstrated by over 2 times’ elevation on the spreading area and enhanced osteogenic activity potentially involving activities of integrin, Vinculin and Yes-associated protein (YAP). In vivo performance of the scaffold identified the inherent osteogenic effect of structural cue, which promotes rapid and uniform regeneration. Overall, the hierarchical scaffold is promising in promoting uniform bone regeneration through its specific structural cue endowed by its micro-nano construction.

KW - ADHESION

KW - ARCHITECTURE

KW - BONE REGENERATION

KW - DIFFERENTIATION

KW - GROWTH

KW - I COLLAGEN

KW - MESENCHYMAL STEM-CELLS

KW - OSSIFICATION

KW - PROTEINS

KW - SURFACES

KW - 116 Chemical sciences

KW - 221 Nano-technology

KW - 317 Pharmacy

UR - https://pubs.rsc.org/en/journals/journalissues/nr#!recentarticles&adv

U2 - 10.1039/C9NR03264A

DO - 10.1039/C9NR03264A

M3 - Article

VL - 11

SP - 15794

EP - 15803

JO - Nanoscale

JF - Nanoscale

SN - 2040-3364

IS - 34

ER -